GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | L | 112 | 34x51 | G.H5 | V | 359 | G.H5.11 |
Hydrophobic | C-term | K | 338 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | TM6 | R | 238 | 6x32 | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | TM6 | A | 239 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | A | 239 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL2 | G | 116 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | G | 116 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Polar | C-term | H | 334 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | H | 334 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | H | 334 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | T | 340 | - | G.s4h3 | E | 248 | G.s4h3.14 |
Van-der-waals | C-term | T | 340 | - | G.s4h3 | E | 248 | G.s4h3.14 |
Hydrophobic | TM5 | M | 206 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | M | 206 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | ICL2 | L | 112 | 34x51 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM5 | R | 205 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | TM5 | R | 205 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | C-term | P | 341 | - | G.H3 | A | 256 | G.H3.07 |
Hydrophobic | TM5 | H | 202 | 5x68 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM5 | H | 202 | 5x68 | G.H5 | L | 368 | G.H5.20 |
Polar | TM6 | R | 238 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | R | 238 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | R | 238 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | C-term | L | 337 | - | G.H3 | L | 257 | G.H3.08 |
Polar | TM6 | R | 235 | 6x29 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | TM6 | R | 235 | 6x29 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | C-term | A | 330 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | A | 330 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | TM5 | R | 205 | 5x71 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | V | 329 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | V | 329 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | ICL3 | A | 213 | - | G.H4 | T | 317 | G.H4.16 |
Hydrophobic | C-term | L | 336 | - | G.H3 | T | 260 | G.H3.11 |
Hydrophobic | C-term | L | 337 | - | G.H3 | T | 260 | G.H3.11 |
Hydrophobic | ICL3 | L | 217 | - | G.H4 | R | 318 | G.H4.17 |
Polar | H8 | R | 299 | 8x48 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM5 | M | 206 | 5x72 | G.S6 | F | 340 | G.S6.02 |
Hydrophobic | ICL3 | L | 214 | - | G.h4s6 | T | 321 | G.h4s6.03 |
Ionic | TM2 | R | 39 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Polar | TM2 | R | 39 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM2 | R | 39 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | TM2 | R | 39 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM5 | V | 198 | 5x64 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM3 | Q | 104 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM5 | H | 202 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM6 | I | 243 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM3 | V | 108 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | V | 108 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | ICL2 | P | 111 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | L | 336 | - | G.H3 | L | 264 | G.H3.15 |
Polar | TM5 | T | 210 | 5x76 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | T | 210 | 5x76 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM5 | V | 209 | 5x75 | G.S6 | F | 340 | G.S6.02 |
Hydrophobic | TM5 | H | 202 | 5x68 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | C-term | L | 337 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | L | 337 | - | G.H2 | R | 216 | G.H2.04 |
Polar | ICL2 | G | 116 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | ICL2 | G | 116 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Van-der-waals | ICL2 | G | 116 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | H8 | P | 300 | 8x49 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM6 | R | 235 | 6x29 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | ICL3 | L | 217 | - | G.h4s6 | T | 321 | G.h4s6.03 |
Hydrophobic | ICL2 | L | 112 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | L | 112 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | A | 199 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | H8 | R | 298 | 8x47 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | ICL2 | L | 112 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | ICL2 | P | 111 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Polar | TM7 | L | 297 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | L | 297 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Aromatic | ICL2 | Y | 114 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | Y | 114 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | Y | 114 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | V | 108 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL2 | G | 116 | 34x55 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | H8 | R | 298 | 8x47 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | ICL2 | P | 111 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | A | 115 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM3 | V | 108 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Polar | TM6 | R | 238 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | R | 238 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | R | 238 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | V | 333 | - | G.H2 | I | 220 | G.H2.08 |
Polar | TM2 | T | 38 | 2x36 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM2 | T | 38 | 2x36 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | TM2 | T | 38 | 2x36 | G.hns1 | R | 40 | G.hns1.02 |
Polar | TM5 | H | 202 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM5 | H | 202 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | H | 202 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | ICL2 | L | 112 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | L | 112 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | ICL3 | L | 216 | - | G.H4 | D | 314 | G.H4.13 |
Hydrophobic | TM6 | R | 235 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | R | 235 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | C-term | L | 337 | - | G.H2 | W | 219 | G.H2.07 |
Hydrophobic | ICL2 | L | 118 | 34x57 | G.hns1 | R | 40 | G.hns1.02 |
Ionic | TM5 | R | 205 | 5x71 | G.H5 | D | 361 | G.H5.13 |
Polar | TM5 | R | 205 | 5x71 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM5 | R | 205 | 5x71 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | R | 205 | 5x71 | G.H5 | D | 361 | G.H5.13 |
Ionic | H8 | R | 299 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Polar | H8 | R | 299 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Hydrophobic | H8 | R | 299 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Van-der-waals | H8 | R | 299 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Polar | ICL2 | A | 115 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | A | 115 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | A | 115 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | P | 111 | 34x50 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM5 | M | 206 | 5x72 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | C-term | S | 321 | - | G.HN | M | 1 | G.HN.01 |
Hydrophobic | C-term | V | 333 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | V | 333 | - | G.H3 | W | 266 | G.H3.17 |
Polar | ICL2 | R | 113 | 34x52 | G.s2s3 | Q | 200 | G.s2s3.01 |
Hydrophobic | ICL2 | A | 115 | 34x54 | G.H5 | V | 363 | G.H5.15 |
Polar | TM5 | H | 202 | 5x68 | G.H5 | A | 365 | G.H5.17 |
Hydrophobic | TM5 | H | 202 | 5x68 | G.H5 | A | 365 | G.H5.17 |
Van-der-waals | TM5 | H | 202 | 5x68 | G.H5 | A | 365 | G.H5.17 |
Hydrophobic | C-term | V | 333 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Hydrophobic | ICL2 | L | 112 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | L | 112 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | C-term | V | 333 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | TM5 | C | 203 | 5x69 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM5 | V | 195 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM5 | V | 195 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | K | 242 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | K | 242 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL2 | A | 115 | 34x54 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | A | 115 | 34x54 | G.S1 | L | 43 | G.S1.02 |