Golf - GPR78 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 85.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 Q 104 3x50 G.H5 L 380 G.H5.25
Van-der-waals TM3 Q 104 3x50 G.H5 L 380 G.H5.25
Polar TM4 R 119 4x38 G.H5 H 374 G.H5.19
Hydrophobic TM4 R 119 4x38 G.H5 H 374 G.H5.19
Van-der-waals TM4 R 119 4x38 G.H5 H 374 G.H5.19
Hydrophobic C-term V 329 - G.H2 I 222 G.H2.08
Hydrophobic C-term M 332 - G.h2s4 F 225 G.h2s4.01
Van-der-waals C-term M 332 - G.h2s4 F 225 G.h2s4.01
Hydrophobic ICL2 G 116 34x55 G.hns1 K 40 G.hns1.02
Hydrophobic C-term L 336 - G.H3 S 262 G.H3.11
Polar TM6 A 239 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 239 6x33 G.H5 L 380 G.H5.25
Van-der-waals TM6 A 239 6x33 G.H5 L 380 G.H5.25
Hydrophobic H8 R 298 8x47 G.H5 E 379 G.H5.24
Van-der-waals H8 R 298 8x47 G.H5 E 379 G.H5.24
Hydrophobic C-term D 328 - G.H3 W 268 G.H3.17
Hydrophobic ICL3 L 217 - G.h4s6 A 338 G.h4s6.04
Ionic TM6 R 238 6x32 G.H5 E 379 G.H5.24
Polar TM6 R 238 6x32 G.H5 E 379 G.H5.24
Hydrophobic TM6 R 238 6x32 G.H5 E 379 G.H5.24
Van-der-waals TM6 R 238 6x32 G.H5 E 379 G.H5.24
Hydrophobic ICL2 L 112 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 112 34x51 G.H5 F 363 G.H5.08
Ionic TM5 H 202 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 202 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 202 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 202 5x68 G.H5 D 368 G.H5.13
Ionic TM6 K 242 6x36 G.H5 E 379 G.H5.24
Polar TM6 K 242 6x36 G.H5 E 379 G.H5.24
Hydrophobic TM6 K 242 6x36 G.H5 E 379 G.H5.24
Van-der-waals TM6 K 242 6x36 G.H5 E 379 G.H5.24
Polar H8 R 299 8x48 G.H5 E 379 G.H5.24
Hydrophobic H8 R 299 8x48 G.H5 E 379 G.H5.24
Van-der-waals H8 R 299 8x48 G.H5 E 379 G.H5.24
Hydrophobic TM4 P 120 4x39 G.HN L 37 G.HN.52
Hydrophobic ICL2 R 113 34x52 G.S3 V 204 G.S3.01
Hydrophobic TM5 C 203 5x69 G.H5 L 381 G.H5.26
Van-der-waals TM5 C 203 5x69 G.H5 L 381 G.H5.26
Hydrophobic ICL2 A 115 34x54 G.hns1 A 41 G.hns1.03
Hydrophobic TM6 K 242 6x36 G.H5 L 380 G.H5.25
Hydrophobic C-term M 332 - G.H3 W 268 G.H3.17
Van-der-waals C-term M 332 - G.H3 W 268 G.H3.17
Hydrophobic TM5 H 202 5x68 G.H5 L 381 G.H5.26
Ionic TM5 R 205 5x71 G.H5 D 368 G.H5.13
Polar TM5 R 205 5x71 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 205 5x71 G.H5 D 368 G.H5.13
Ionic C-term D 328 - G.H3 R 267 G.H3.16
Polar C-term D 328 - G.H3 R 267 G.H3.16
Hydrophobic C-term D 328 - G.H3 R 267 G.H3.16
Van-der-waals C-term D 328 - G.H3 R 267 G.H3.16
Hydrophobic ICL2 P 111 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 111 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 P 111 34x50 G.H5 Q 371 G.H5.16
Van-der-waals ICL2 P 111 34x50 G.H5 Q 371 G.H5.16
Hydrophobic ICL2 P 111 34x50 G.H5 R 367 G.H5.12
Van-der-waals ICL2 P 111 34x50 G.H5 R 367 G.H5.12
Hydrophobic TM5 H 202 5x68 G.H5 L 375 G.H5.20
Van-der-waals TM5 H 202 5x68 G.H5 L 375 G.H5.20
Hydrophobic TM6 R 235 6x29 G.H5 L 381 G.H5.26
Van-der-waals TM6 R 235 6x29 G.H5 L 381 G.H5.26
Polar TM5 H 202 5x68 G.H5 R 372 G.H5.17
Hydrophobic TM5 H 202 5x68 G.H5 R 372 G.H5.17
Van-der-waals TM5 H 202 5x68 G.H5 R 372 G.H5.17
Hydrophobic TM2 R 39 2x37 G.H5 Q 377 G.H5.22
Van-der-waals TM2 R 39 2x37 G.H5 Q 377 G.H5.22
Hydrophobic TM3 V 108 3x54 G.H5 H 374 G.H5.19
Polar TM3 D 103 3x49 G.H5 Y 378 G.H5.23
Hydrophobic TM3 A 107 3x53 G.H5 Y 378 G.H5.23
Hydrophobic ICL2 G 116 34x55 G.hns1 A 41 G.hns1.03
Van-der-waals ICL2 G 116 34x55 G.hns1 A 41 G.hns1.03
Polar TM3 A 107 3x53 G.H5 H 374 G.H5.19
Hydrophobic TM3 A 107 3x53 G.H5 H 374 G.H5.19
Van-der-waals TM3 A 107 3x53 G.H5 H 374 G.H5.19
Polar TM6 R 238 6x32 G.H5 L 381 G.H5.26
Hydrophobic TM6 R 238 6x32 G.H5 L 381 G.H5.26
Van-der-waals TM6 R 238 6x32 G.H5 L 381 G.H5.26
Hydrophobic TM3 Q 104 3x50 G.H5 Y 378 G.H5.23
Van-der-waals TM3 Q 104 3x50 G.H5 Y 378 G.H5.23
Hydrophobic TM5 M 206 5x72 G.h4s6 Y 345 G.h4s6.20
Van-der-waals TM5 M 206 5x72 G.h4s6 Y 345 G.h4s6.20
Hydrophobic TM6 I 243 6x37 G.H5 L 380 G.H5.25
Ionic ICL3 K 212 - G.hgh4 D 310 G.hgh4.13
Polar ICL3 K 212 - G.hgh4 D 310 G.hgh4.13
Hydrophobic ICL3 K 212 - G.hgh4 D 310 G.hgh4.13
Van-der-waals ICL3 K 212 - G.hgh4 D 310 G.hgh4.13
Hydrophobic TM3 V 108 3x54 G.H5 Y 378 G.H5.23
Hydrophobic ICL2 L 112 34x51 G.S3 F 206 G.S3.03
Polar ICL2 R 113 34x52 G.s2s3 D 202 G.s2s3.01
Van-der-waals ICL2 R 113 34x52 G.s2s3 D 202 G.s2s3.01
Hydrophobic ICL2 A 115 34x54 G.hns1 K 40 G.hns1.02
Van-der-waals ICL2 A 115 34x54 G.hns1 K 40 G.hns1.02
Van-der-waals C-term R 339 - G.H2 R 215 G.H2.01
Polar TM3 V 108 3x54 G.H5 Q 371 G.H5.16
Hydrophobic TM3 V 108 3x54 G.H5 Q 371 G.H5.16
Van-der-waals TM3 V 108 3x54 G.H5 Q 371 G.H5.16
Hydrophobic TM5 V 195 5x61 G.H5 L 380 G.H5.25
Van-der-waals TM5 V 195 5x61 G.H5 L 380 G.H5.25
Polar TM3 G 109 3x55 G.H5 Q 371 G.H5.16
Polar TM5 H 202 5x68 G.H5 Q 371 G.H5.16
Hydrophobic TM5 H 202 5x68 G.H5 Q 371 G.H5.16
Van-der-waals TM5 H 202 5x68 G.H5 Q 371 G.H5.16
Hydrophobic TM5 V 198 5x64 G.H5 Q 371 G.H5.16
Hydrophobic ICL3 L 217 - G.h4s6 T 337 G.h4s6.03
Hydrophobic C-term M 332 - G.H2 I 222 G.H2.08
Van-der-waals C-term M 332 - G.H2 I 222 G.H2.08
Hydrophobic TM5 A 199 5x65 G.H5 L 375 G.H5.20
Polar ICL2 L 112 34x51 G.S1 H 43 G.S1.02
Hydrophobic ICL2 L 112 34x51 G.S1 H 43 G.S1.02
Van-der-waals ICL2 L 112 34x51 G.S1 H 43 G.S1.02
Ionic C-term R 339 - G.s4h3 D 247 G.s4h3.11
Hydrophobic TM5 M 206 5x72 G.H5 R 372 G.H5.17
Van-der-waals TM5 M 206 5x72 G.H5 R 372 G.H5.17
Hydrophobic ICL3 A 213 - G.h4s6 T 337 G.h4s6.03
Van-der-waals ICL3 A 213 - G.h4s6 T 337 G.h4s6.03
Hydrophobic ICL2 L 112 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 112 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 112 34x51 G.H5 C 366 G.H5.11
Hydrophobic ICL3 L 216 - G.H4 R 334 G.H4.17
Polar TM6 R 235 6x29 G.h4s6 Y 345 G.h4s6.20
Hydrophobic TM6 R 238 6x32 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 112 34x51 G.S3 V 204 G.S3.01
Van-der-waals ICL2 L 112 34x51 G.S3 V 204 G.S3.01
Hydrophobic ICL2 L 112 34x51 G.H5 R 367 G.H5.12
Hydrophobic TM3 V 108 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM5 V 198 5x64 G.H5 L 375 G.H5.20
Aromatic ICL2 Y 114 34x53 G.H5 H 374 G.H5.19
Hydrophobic ICL2 Y 114 34x53 G.H5 H 374 G.H5.19
Hydrophobic TM5 V 195 5x61 G.H5 L 375 G.H5.20
Ionic H8 R 302 8x51 G.H5 E 379 G.H5.24
Polar H8 R 302 8x51 G.H5 E 379 G.H5.24
Hydrophobic ICL2 A 115 34x54 G.S1 H 43 G.S1.02
Van-der-waals ICL2 A 115 34x54 G.S1 H 43 G.S1.02