Gt2 - GPR78 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 112 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM6 K 242 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 K 242 6x36 G.H5 L 353 G.H5.25
Polar TM6 R 238 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 238 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 238 6x32 G.H5 F 354 G.H5.26
Ionic TM5 R 205 5x71 G.H5 D 341 G.H5.13
Polar TM5 R 205 5x71 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 205 5x71 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 205 5x71 G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 111 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 111 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL3 L 217 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 L 217 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL2 L 112 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 112 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM3 V 108 3x54 G.H5 N 347 G.H5.19
Polar ICL2 G 116 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 G 116 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 G 116 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic TM5 V 209 5x75 G.S6 I 319 G.S6.01
Van-der-waals TM5 V 209 5x75 G.S6 I 319 G.S6.01
Hydrophobic C-term V 333 - G.H2 K 209 G.H2.05
Van-der-waals C-term V 333 - G.H2 K 209 G.H2.05
Ionic TM5 R 205 5x71 G.H5 D 337 G.H5.09
Polar TM5 R 205 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 205 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 R 205 5x71 G.H5 D 337 G.H5.09
Polar TM6 A 239 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 239 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 239 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 111 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 111 34x50 G.H5 I 344 G.H5.16
Hydrophobic H8 P 300 8x49 G.H5 D 350 G.H5.22
Hydrophobic ICL3 A 213 - G.H4 L 308 G.H4.16
Van-der-waals ICL3 A 213 - G.H4 L 308 G.H4.16
Ionic TM5 H 202 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 202 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 202 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 202 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM3 V 108 3x54 G.H5 L 348 G.H5.20
Ionic TM2 R 39 2x37 G.H5 D 350 G.H5.22
Polar TM2 R 39 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 39 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM6 R 235 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 235 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL3 K 212 - G.H4 L 308 G.H4.16
Hydrophobic ICL2 A 115 34x54 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 A 115 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic C-term M 332 - G.H3 H 256 G.H3.15
Van-der-waals C-term M 332 - G.H3 H 256 G.H3.15
Hydrophobic ICL2 L 112 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 112 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM5 A 199 5x65 G.H5 L 348 G.H5.20
Hydrophobic C-term R 339 - G.s4h3 V 240 G.s4h3.14
Van-der-waals C-term R 339 - G.s4h3 V 240 G.s4h3.14
Hydrophobic C-term V 329 - G.H3 F 258 G.H3.17
Hydrophobic C-term L 336 - G.H3 S 252 G.H3.11
Van-der-waals C-term L 336 - G.H3 S 252 G.H3.11
Hydrophobic TM5 H 202 5x68 G.H5 F 354 G.H5.26
Hydrophobic TM5 V 209 5x75 G.S6 Y 320 G.S6.02
Hydrophobic C-term M 332 - G.H2 I 212 G.H2.08
Van-der-waals C-term M 332 - G.H2 I 212 G.H2.08
Van-der-waals TM6 K 242 6x36 G.H5 G 352 G.H5.24
Hydrophobic ICL3 L 214 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 L 214 - G.h4s6 K 314 G.h4s6.08
Ionic ICL1 R 37 12x51 G.HN E 20 G.HN.44
Polar ICL1 R 37 12x51 G.HN E 20 G.HN.44
Van-der-waals ICL1 R 37 12x51 G.HN E 20 G.HN.44
Polar H8 R 298 8x47 G.H5 C 351 G.H5.23
Hydrophobic H8 R 298 8x47 G.H5 C 351 G.H5.23
Hydrophobic C-term M 332 - G.H3 F 259 G.H3.18
Hydrophobic C-term M 332 - G.H3 F 258 G.H3.17
Van-der-waals C-term M 332 - G.H3 F 258 G.H3.17
Hydrophobic TM5 M 206 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 M 206 5x72 G.H5 D 341 G.H5.13
Hydrophobic C-term L 336 - G.H3 I 253 G.H3.12
Ionic C-term D 328 - G.H3 K 257 G.H3.16
Polar C-term D 328 - G.H3 K 257 G.H3.16
Hydrophobic C-term D 328 - G.H3 K 257 G.H3.16
Van-der-waals C-term D 328 - G.H3 K 257 G.H3.16
Hydrophobic TM5 M 206 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 M 206 5x72 G.S6 Y 320 G.S6.02
Ionic TM6 R 235 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 L 216 - G.H4 S 305 G.H4.13
Van-der-waals ICL3 L 216 - G.H4 S 305 G.H4.13
Polar TM3 Q 104 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 Q 104 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 Q 104 3x50 G.H5 C 351 G.H5.23
Polar TM2 T 38 2x36 G.HN Q 24 G.HN.48
Hydrophobic TM2 T 38 2x36 G.HN Q 24 G.HN.48
Van-der-waals TM2 T 38 2x36 G.HN Q 24 G.HN.48
Hydrophobic ICL3 L 217 - G.H4 D 309 G.H4.17
Van-der-waals ICL3 L 217 - G.H4 D 309 G.H4.17
Ionic H8 R 299 8x48 G.H5 E 346 G.H5.18
Polar H8 R 299 8x48 G.H5 E 346 G.H5.18
Hydrophobic C-term M 332 - G.h2s4 F 215 G.h2s4.01
Van-der-waals C-term M 332 - G.h2s4 F 215 G.h2s4.01
Hydrophobic TM5 V 195 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 V 195 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 112 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 112 34x51 G.H5 I 343 G.H5.15
Ionic C-term R 339 - G.s4h3 D 237 G.s4h3.11
Polar C-term R 339 - G.s4h3 D 237 G.s4h3.11
Hydrophobic C-term R 339 - G.s4h3 D 237 G.s4h3.11
Van-der-waals C-term R 339 - G.s4h3 D 237 G.s4h3.11
Hydrophobic ICL2 P 111 34x50 G.H5 T 340 G.H5.12
Ionic TM4 R 119 4x38 G.HN D 28 G.HN.52
Polar TM4 R 119 4x38 G.HN D 28 G.HN.52
Hydrophobic TM5 H 202 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 202 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 A 115 34x54 G.S3 L 194 G.S3.01
Polar TM3 A 107 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 107 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 107 3x53 G.H5 N 347 G.H5.19
Hydrophobic C-term L 336 - G.H3 L 249 G.H3.08
Van-der-waals C-term L 336 - G.H3 L 249 G.H3.08
Hydrophobic TM5 M 206 5x72 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 M 206 5x72 G.h4s6 E 318 G.h4s6.12
Polar TM5 H 202 5x68 G.H5 K 345 G.H5.17
Hydrophobic TM5 H 202 5x68 G.H5 K 345 G.H5.17
Polar TM6 Q 231 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 Q 231 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 Q 231 6x25 G.h4s6 D 315 G.h4s6.09
Polar TM6 R 235 6x29 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 235 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM4 R 119 4x38 G.hns1 A 31 G.hns1.02
Hydrophobic C-term L 337 - G.H2 K 209 G.H2.05
Van-der-waals C-term L 337 - G.H2 K 209 G.H2.05
Hydrophobic TM6 I 243 6x37 G.H5 L 353 G.H5.25
Hydrophobic C-term R 339 - G.H2 R 205 G.H2.01
Van-der-waals C-term R 339 - G.H2 R 205 G.H2.01
Hydrophobic TM5 H 202 5x68 G.H5 L 348 G.H5.20
Van-der-waals H8 R 298 8x47 G.H5 D 350 G.H5.22
Hydrophobic C-term V 329 - G.H2 I 212 G.H2.08
Van-der-waals C-term V 329 - G.H2 I 212 G.H2.08