G13 -
mGlu2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | F | 661 | 3x58 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | F | 661 | 3x58 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL3 | P | 753 | - | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | ICL3 | P | 753 | - | G.H5 | H | 368 | G.H5.17 |
Polar | ICL2 | R | 670 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | R | 670 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | R | 670 | - | G.hns1 | K | 46 | G.hns1.02 |
Polar | ICL2 | R | 670 | - | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | ICL2 | R | 670 | - | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | H8 | R | 829 | 8x54 | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | H8 | H | 828 | 8x53 | G.h4s6 | P | 341 | G.h4s6.20 |
Van-der-waals | H8 | H | 828 | 8x53 | G.h4s6 | P | 341 | G.h4s6.20 |
Polar | TM3 | R | 656 | 3x53 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | R | 656 | 3x53 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | I | 660 | 3x57 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | G | 667 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ICL2 | G | 667 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | ICL2 | G | 667 | - | G.S3 | V | 216 | G.S3.01 |
Polar | ICL2 | R | 672 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | R | 672 | - | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | R | 672 | - | G.HN | T | 43 | G.HN.52 |
Polar | ICL1 | A | 600 | 12x52 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL1 | A | 600 | 12x52 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | ICL1 | A | 600 | 12x52 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | R | 672 | - | G.HN | R | 40 | G.HN.49 |
Hydrophobic | C-term | F | 854 | - | G.h4s6 | D | 336 | G.h4s6.10 |
Van-der-waals | C-term | F | 854 | - | G.h4s6 | D | 336 | G.h4s6.10 |
Hydrophobic | C-term | G | 861 | - | G.H2 | F | 234 | G.H2.08 |
Hydrophobic | ICL1 | K | 599 | 12x51 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | ICL1 | K | 599 | 12x51 | G.H5 | M | 375 | G.H5.24 |
Polar | ICL2 | Q | 669 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | Q | 669 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 669 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | R | 670 | - | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | ICL2 | R | 670 | - | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL1 | K | 599 | 12x51 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | A | 664 | - | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | ICL2 | A | 664 | - | G.H5 | L | 371 | G.H5.20 |
Polar | C-term | C | 859 | - | G.H3 | N | 278 | G.H3.15 |
Hydrophobic | C-term | C | 859 | - | G.H3 | N | 278 | G.H3.15 |
Van-der-waals | C-term | C | 859 | - | G.H3 | N | 278 | G.H3.15 |
Hydrophobic | ICL2 | Q | 669 | - | G.S3 | P | 217 | G.S3.02 |
Polar | ICL2 | R | 670 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | R | 670 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | R | 670 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | C-term | R | 862 | - | G.H2 | F | 234 | G.H2.08 |
Van-der-waals | C-term | R | 862 | - | G.H2 | F | 234 | G.H2.08 |
Hydrophobic | ICL2 | P | 671 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | P | 671 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | A | 668 | - | G.S3 | P | 217 | G.S3.02 |
Polar | TM3 | R | 656 | 3x53 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM3 | R | 656 | 3x53 | G.H5 | Q | 377 | G.H5.26 |
Polar | C-term | V | 855 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | V | 855 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | V | 855 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | ICL2 | Q | 669 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Polar | ICL2 | E | 666 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | ICL2 | E | 666 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ICL2 | E | 666 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Polar | TM3 | R | 656 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | R | 656 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM6 | F | 756 | 6x33 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM6 | F | 756 | 6x33 | G.H5 | K | 372 | G.H5.21 |
Polar | H8 | H | 828 | 8x53 | G.h4s6 | K | 340 | G.h4s6.19 |
Hydrophobic | H8 | H | 828 | 8x53 | G.h4s6 | K | 340 | G.h4s6.19 |
Van-der-waals | H8 | H | 828 | 8x53 | G.h4s6 | K | 340 | G.h4s6.19 |
Polar | ICL2 | A | 668 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | H8 | V | 826 | 8x51 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM6 | F | 756 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | C-term | T | 857 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | T | 857 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | TM4 | P | 676 | 4x29 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM4 | P | 676 | 4x29 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL3 | N | 755 | - | G.H5 | K | 372 | G.H5.21 |
Polar | C-term | F | 854 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | F | 854 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | F | 854 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | P | 856 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | P | 856 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | C | 859 | - | G.H3 | V | 280 | G.H3.17 |
Van-der-waals | C-term | C | 859 | - | G.H3 | V | 280 | G.H3.17 |
Hydrophobic | TM3 | F | 661 | 3x58 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | F | 661 | 3x58 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | H8 | A | 830 | 8x55 | G.h4s6 | P | 341 | G.h4s6.20 |
Van-der-waals | H8 | A | 830 | 8x55 | G.h4s6 | P | 341 | G.h4s6.20 |
Polar | H8 | S | 827 | 8x52 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | H8 | S | 827 | 8x52 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | ICL2 | E | 666 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | ICL2 | E | 666 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | ICL2 | A | 668 | - | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | ICL2 | A | 668 | - | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL2 | I | 674 | - | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | A | 668 | - | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | A | 668 | - | G.S3 | V | 216 | G.S3.01 |
Polar | H8 | R | 829 | 8x54 | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | H8 | R | 829 | 8x54 | G.S6 | Y | 343 | G.S6.02 |
Aromatic | TM6 | F | 756 | 6x33 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | F | 756 | 6x33 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | F | 756 | 6x33 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM3 | I | 660 | 3x57 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | I | 660 | 3x57 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL1 | P | 596 | 12x48 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | ICL1 | P | 596 | 12x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | C-term | L | 872 | - | H.hbhc | A | 133 | H.hbhc.06 |
Polar | ICL2 | G | 667 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | ICL2 | G | 667 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | ICL2 | G | 667 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | ICL1 | A | 600 | 12x52 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | A | 668 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | A | 668 | - | G.hns1 | R | 47 | G.hns1.03 |
Ionic | H8 | H | 828 | 8x53 | G.H5 | D | 369 | G.H5.18 |
Polar | H8 | H | 828 | 8x53 | G.H5 | D | 369 | G.H5.18 |
Hydrophobic | H8 | H | 828 | 8x53 | G.H5 | D | 369 | G.H5.18 |
Hydrophobic | H8 | P | 831 | 8x56 | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | H8 | P | 831 | 8x56 | G.S6 | Y | 343 | G.S6.02 |
Polar | ICL3 | N | 755 | - | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ICL3 | N | 755 | - | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | ICL3 | N | 755 | - | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | H8 | P | 831 | 8x56 | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | TM6 | F | 756 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | F | 756 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | V | 864 | - | G.H2 | E | 235 | G.H2.09 |
Van-der-waals | C-term | V | 864 | - | G.H2 | E | 235 | G.H2.09 |