G12 - mGlu4 receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term Y 907 - H.HA G 104 H.HA.18
Van-der-waals C-term Y 907 - H.HA G 104 H.HA.18
Hydrophobic TM3 I 680 3x57 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 680 3x57 G.H5 L 375 G.H5.20
Hydrophobic C-term Y 907 - H.HA K 103 H.HA.17
Van-der-waals C-term Y 907 - H.HA K 103 H.HA.17
Polar C-term A 885 - G.S2 H 214 G.S2.04
Hydrophobic C-term A 885 - G.S2 H 214 G.S2.04
Van-der-waals C-term A 885 - G.S2 H 214 G.S2.04
Hydrophobic ICL3 P 778 - G.H5 Q 372 G.H5.17
Hydrophobic C-term Y 904 - H.hdhe F 173 H.hdhe.01
Ionic H8 R 858 8x55 G.H5 D 377 G.H5.22
Polar H8 R 858 8x55 G.H5 D 377 G.H5.22
Van-der-waals H8 R 858 8x55 G.H5 D 377 G.H5.22
Polar C-term H 910 - G.s3h2 Q 231 G.s3h2.03
Hydrophobic C-term H 910 - G.s3h2 Q 231 G.s3h2.03
Van-der-waals C-term H 910 - G.s3h2 Q 231 G.s3h2.03
Van-der-waals TM3 G 684 3x61 G.H5 L 371 G.H5.16
Hydrophobic ICL2 V 688 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 V 688 - G.H5 N 374 G.H5.19
Hydrophobic C-term Y 907 - H.HA V 107 H.HA.21
Hydrophobic TM3 K 685 3x62 G.H5 L 371 G.H5.16
Polar C-term K 886 - G.S2 E 213 G.S2.03
Van-der-waals C-term K 886 - G.S2 E 213 G.S2.03
Aromatic H8 R 856 8x53 G.h3s5 F 287 G.h3s5.01
Hydrophobic H8 R 856 8x53 G.h3s5 F 287 G.h3s5.01
Hydrophobic ICL2 S 689 - G.H5 I 378 G.H5.23
Hydrophobic ICL3 F 781 - G.H5 L 375 G.H5.20
Van-der-waals ICL3 F 781 - G.H5 L 375 G.H5.20
Polar ICL2 S 689 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 S 689 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 S 689 - G.hns1 R 55 G.hns1.02
Hydrophobic H8 R 858 8x55 G.h3s5 V 289 G.h3s5.03
Van-der-waals H8 R 858 8x55 G.h3s5 V 289 G.h3s5.03
Hydrophobic C-term V 905 - H.HB M 132 H.HB.10
Polar C-term N 909 - H.HA K 103 H.HA.17
Hydrophobic C-term N 909 - H.HA K 103 H.HA.17
Van-der-waals C-term N 909 - H.HA K 103 H.HA.17
Polar C-term T 903 - H.HA K 114 H.HA.28
Hydrophobic C-term T 903 - H.HA K 114 H.HA.28
Van-der-waals C-term T 903 - H.HA K 114 H.HA.28
Hydrophobic TM3 I 677 3x54 G.H5 M 379 G.H5.24
Polar C-term C 890 - G.H2 K 237 G.H2.06
Hydrophobic C-term C 890 - G.H2 K 237 G.H2.06
Van-der-waals C-term C 890 - G.H2 K 237 G.H2.06
Hydrophobic C-term N 882 - G.h1ha G 82 G.h1ha.01
Van-der-waals C-term N 882 - G.h1ha G 82 G.h1ha.01
Polar C-term G 883 - G.S2 D 215 G.S2.05
Hydrophobic C-term G 883 - G.S2 D 215 G.S2.05
Van-der-waals C-term G 883 - G.S2 D 215 G.S2.05
Polar C-term L 893 - G.H2 K 237 G.H2.06
Hydrophobic C-term L 893 - G.H2 K 237 G.H2.06
Aromatic C-term Y 904 - H.HA K 114 H.HA.28
Hydrophobic C-term Y 904 - H.HA K 114 H.HA.28
Van-der-waals C-term Y 904 - H.HA K 114 H.HA.28
Hydrophobic ICL3 F 781 - G.H5 M 379 G.H5.24
Van-der-waals ICL3 F 781 - G.H5 M 379 G.H5.24
Hydrophobic ICL2 R 692 - G.HN R 52 G.HN.52
Van-der-waals ICL2 R 692 - G.HN R 52 G.HN.52
Polar H8 R 856 8x53 G.h3s5 N 288 G.h3s5.02
Van-der-waals H8 R 856 8x53 G.h3s5 N 288 G.h3s5.02
Hydrophobic TM3 G 684 3x61 G.H5 L 375 G.H5.20
Van-der-waals TM3 G 684 3x61 G.H5 L 375 G.H5.20
Hydrophobic TM3 R 686 3x63 G.S3 I 221 G.S3.01
Van-der-waals TM3 R 686 3x63 G.S3 I 221 G.S3.01
Polar ICL2 S 689 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 S 689 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 S 689 - G.hns1 R 56 G.hns1.03
Hydrophobic TM3 S 687 3x64 G.S3 I 221 G.S3.01
Van-der-waals TM3 S 687 3x64 G.S3 I 221 G.S3.01
Hydrophobic C-term P 881 - G.h1ha R 83 G.h1ha.02
Hydrophobic C-term T 908 - G.s4h3 M 262 G.s4h3.09
Van-der-waals C-term T 908 - G.s4h3 M 262 G.s4h3.09
Polar C-term Y 907 - H.HA N 100 H.HA.14
Hydrophobic C-term Y 907 - H.HA N 100 H.HA.14
Van-der-waals C-term Y 907 - H.HA N 100 H.HA.14
Hydrophobic ICL1 A 620 12x52 G.H5 L 380 G.H5.25
Hydrophobic C-term Y 904 - H.HA D 110 H.HA.24
Van-der-waals C-term Y 904 - H.HA D 110 H.HA.24
Polar C-term N 882 - G.S2 V 217 G.S2.07
Hydrophobic C-term N 882 - G.S2 V 217 G.S2.07
Van-der-waals C-term N 882 - G.S2 V 217 G.S2.07
Hydrophobic ICL3 F 781 - G.H5 K 376 G.H5.21
Van-der-waals ICL3 F 781 - G.H5 K 376 G.H5.21
Hydrophobic C-term T 906 - H.HA V 107 H.HA.21
Hydrophobic TM3 F 681 3x58 G.H5 L 375 G.H5.20
Hydrophobic C-term Y 904 - H.HA A 111 H.HA.25
Polar H8 R 858 8x55 G.H5 N 374 G.H5.19
Hydrophobic C-term V 905 - H.HA R 106 H.HA.20
Polar C-term N 909 - H.HA D 99 H.HA.13
Van-der-waals C-term N 909 - H.HA D 99 H.HA.13
Polar H8 K 857 8x54 G.h3s5 N 288 G.h3s5.02
Hydrophobic H8 K 857 8x54 G.h3s5 N 288 G.h3s5.02
Van-der-waals H8 K 857 8x54 G.h3s5 N 288 G.h3s5.02
Hydrophobic C-term Y 907 - H.hdhe Q 174 H.hdhe.02
Van-der-waals C-term Y 907 - H.hdhe Q 174 H.hdhe.02
Hydrophobic C-term A 885 - G.S2 V 212 G.S2.02
Van-der-waals C-term A 885 - G.S2 V 212 G.S2.02
Polar C-term E 888 - G.S2 I 211 G.S2.01
Van-der-waals C-term E 888 - G.S2 I 211 G.S2.01
Polar C-term N 882 - G.H1 H 81 G.H1.12
Van-der-waals C-term N 882 - G.H1 H 81 G.H1.12
Hydrophobic C-term K 886 - G.S2 V 212 G.S2.02
Van-der-waals C-term K 886 - G.S2 V 212 G.S2.02
Polar H8 R 858 8x55 G.h3s5 N 288 G.h3s5.02
Hydrophobic H8 R 858 8x55 G.h3s5 N 288 G.h3s5.02
Van-der-waals H8 R 858 8x55 G.h3s5 N 288 G.h3s5.02
Hydrophobic C-term V 905 - H.HA V 107 H.HA.21
Van-der-waals C-term V 905 - H.HA V 107 H.HA.21
Hydrophobic C-term N 909 - G.hfs2 A 207 G.hfs2.04
Hydrophobic TM3 I 680 3x57 G.H5 I 378 G.H5.23
Hydrophobic C-term V 863 - G.h2s4 G 244 G.h2s4.03
Hydrophobic C-term G 883 - G.S2 F 216 G.S2.06
Van-der-waals C-term G 883 - G.S2 F 216 G.S2.06
Hydrophobic C-term Y 907 - H.hdhe G 176 H.hdhe.04
Van-der-waals C-term Y 907 - H.hdhe G 176 H.hdhe.04
Polar C-term N 882 - G.h1ha R 83 G.h1ha.02
Hydrophobic C-term N 882 - G.h1ha R 83 G.h1ha.02
Van-der-waals C-term N 882 - G.h1ha R 83 G.h1ha.02
Polar H8 R 858 8x55 G.h2s4 T 246 G.h2s4.05
Van-der-waals H8 R 858 8x55 G.h2s4 T 246 G.h2s4.05
Polar C-term Q 902 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term Q 902 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term Q 902 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term A 866 - G.h2s4 D 243 G.h2s4.02
Van-der-waals C-term A 866 - G.h2s4 D 243 G.h2s4.02
Hydrophobic C-term Y 907 - H.hdhe L 175 H.hdhe.03
Polar C-term G 883 - G.S2 H 214 G.S2.04
Polar ICL3 T 780 - G.H5 K 376 G.H5.21
Hydrophobic ICL3 T 780 - G.H5 K 376 G.H5.21
Van-der-waals ICL3 T 780 - G.H5 K 376 G.H5.21
Hydrophobic C-term T 906 - G.s4h3 M 262 G.s4h3.09
Van-der-waals C-term T 906 - G.s4h3 M 262 G.s4h3.09
Hydrophobic ICL2 V 688 - G.H5 L 371 G.H5.16
Van-der-waals ICL2 V 688 - G.H5 L 371 G.H5.16
Polar TM3 R 676 3x53 G.H5 Q 381 G.H5.26
Van-der-waals TM3 R 676 3x53 G.H5 Q 381 G.H5.26
Hydrophobic TM3 I 680 3x57 G.H5 M 379 G.H5.24
Hydrophobic ICL2 V 688 - G.S1 V 58 G.S1.02
Van-der-waals ICL2 V 688 - G.S1 V 58 G.S1.02
Polar C-term E 884 - G.S2 D 215 G.S2.05
Hydrophobic ICL2 V 688 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 V 688 - G.hns1 R 55 G.hns1.02
Polar C-term V 905 - H.HA D 110 H.HA.24
Hydrophobic C-term V 905 - H.HA D 110 H.HA.24
Van-der-waals C-term V 905 - H.HA D 110 H.HA.24
Hydrophobic C-term N 882 - G.S2 F 216 G.S2.06
Van-der-waals C-term N 882 - G.S2 F 216 G.S2.06
Hydrophobic C-term S 887 - G.S2 V 212 G.S2.02
Hydrophobic ICL2 V 688 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 V 688 - G.hns1 R 56 G.hns1.03
Polar C-term C 890 - G.H2 Q 240 G.H2.09
Hydrophobic C-term C 890 - G.H2 Q 240 G.H2.09
Van-der-waals C-term C 890 - G.H2 Q 240 G.H2.09
Hydrophobic ICL2 V 688 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 V 688 - G.S3 I 221 G.S3.01
Hydrophobic C-term G 883 - G.H1 R 78 G.H1.09
Hydrophobic C-term Y 907 - H.HE V 179 H.HE.02
Van-der-waals C-term Y 907 - H.HE V 179 H.HE.02
Hydrophobic ICL2 A 690 - G.H5 I 378 G.H5.23