G12 - mGlu7 receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 23.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term Y 907 - H.HD E 172 H.HD.12
Van-der-waals C-term Y 907 - H.HD E 172 H.HD.12
Polar C-term I 915 - H.HA K 103 H.HA.17
Hydrophobic C-term I 915 - H.HA K 103 H.HA.17
Van-der-waals C-term I 915 - H.HA K 103 H.HA.17
Polar C-term S 873 - G.H2 F 239 G.H2.08
Hydrophobic C-term S 873 - G.H2 F 239 G.H2.08
Hydrophobic C-term V 908 - H.HA K 114 H.HA.28
Van-der-waals C-term V 908 - H.HA K 114 H.HA.28
Hydrophobic TM6 F 784 6x33 G.H5 Q 372 G.H5.17
Van-der-waals TM6 F 784 6x33 G.H5 Q 372 G.H5.17
Polar C-term L 876 - G.H2 R 235 G.H2.04
Hydrophobic C-term L 876 - G.H2 R 235 G.H2.04
Van-der-waals C-term L 876 - G.H2 R 235 G.H2.04
Hydrophobic C-term L 876 - G.H3 I 280 G.H3.12
Polar C-term S 909 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term S 909 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term S 909 - G.s4h3 R 265 G.s4h3.12
Polar ICL1 A 623 12x52 G.H5 M 379 G.H5.24
Hydrophobic ICL1 A 623 12x52 G.H5 M 379 G.H5.24
Van-der-waals ICL1 A 623 12x52 G.H5 M 379 G.H5.24
Hydrophobic C-term L 876 - G.H3 I 276 G.H3.08
Hydrophobic ICL3 E 782 - G.H5 K 376 G.H5.21
Polar C-term R 883 - G.H3 T 279 G.H3.11
Hydrophobic C-term M 872 - G.H3 I 280 G.H3.12
Van-der-waals C-term M 872 - G.H3 I 280 G.H3.12
Van-der-waals C-term Y 910 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term Y 910 - H.hdhe F 173 H.hdhe.01
Van-der-waals C-term Y 910 - H.hdhe F 173 H.hdhe.01
Hydrophobic ICL2 S 690 - G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 S 690 - G.s2s3 K 220 G.s2s3.02
Polar C-term T 868 - G.H3 N 283 G.H3.15
Hydrophobic C-term Y 907 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term N 911 - G.s4h3 M 262 G.s4h3.09
Van-der-waals C-term N 911 - G.s4h3 M 262 G.s4h3.09
Hydrophobic C-term Y 907 - G.s4h3 V 260 G.s4h3.07
Van-der-waals C-term Y 907 - G.s4h3 V 260 G.s4h3.07
Hydrophobic C-term V 866 - G.H2 F 239 G.H2.08
Hydrophobic C-term A 869 - G.h2s4 F 242 G.h2s4.01
Van-der-waals C-term A 869 - G.h2s4 F 242 G.h2s4.01
Polar ICL1 R 622 12x51 G.H5 Q 381 G.H5.26
Hydrophobic ICL1 R 622 12x51 G.H5 Q 381 G.H5.26
Van-der-waals ICL1 R 622 12x51 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 V 691 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 V 691 - G.S3 I 221 G.S3.01
Hydrophobic TM3 F 684 3x58 G.H5 L 375 G.H5.20
Hydrophobic C-term M 872 - G.H3 N 283 G.H3.15
Van-der-waals C-term M 872 - G.H3 N 283 G.H3.15
Hydrophobic C-term M 872 - G.h2s4 F 242 G.h2s4.01
Van-der-waals C-term M 872 - G.h2s4 F 242 G.h2s4.01
Polar C-term S 873 - G.H2 R 235 G.H2.04
Van-der-waals C-term S 873 - G.H2 R 235 G.H2.04
Polar ICL2 S 690 - G.s2s3 K 219 G.s2s3.01
Hydrophobic ICL2 S 690 - G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 S 690 - G.s2s3 K 219 G.s2s3.01
Polar ICL3 N 783 - G.H5 K 376 G.H5.21
Hydrophobic ICL3 N 783 - G.H5 K 376 G.H5.21
Van-der-waals ICL3 N 783 - G.H5 K 376 G.H5.21
Hydrophobic TM6 F 784 6x33 G.H5 K 376 G.H5.21
Van-der-waals TM6 F 784 6x33 G.H5 K 376 G.H5.21
Polar C-term Y 910 - H.HA A 111 H.HA.25
Hydrophobic C-term Y 910 - H.HA A 111 H.HA.25
Van-der-waals C-term Y 910 - H.HA A 111 H.HA.25
Hydrophobic C-term Y 910 - H.hdhe Q 174 H.hdhe.02
Polar C-term N 911 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term N 911 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term N 911 - G.s4h3 R 265 G.s4h3.12
Hydrophobic ICL3 P 781 - G.H5 K 376 G.H5.21
Hydrophobic TM6 E 786 6x35 G.H5 M 379 G.H5.24
Hydrophobic C-term A 870 - G.H2 F 239 G.H2.08
Hydrophobic ICL1 P 619 12x48 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 683 3x57 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 683 3x57 G.H5 L 375 G.H5.20
Polar H8 R 859 8x53 G.h3s5 N 288 G.h3s5.02
Van-der-waals H8 R 859 8x53 G.h3s5 N 288 G.h3s5.02
Polar H8 R 861 8x55 G.H3 K 284 G.H3.16
Hydrophobic H8 R 861 8x55 G.H3 K 284 G.H3.16
Van-der-waals H8 R 861 8x55 G.H3 K 284 G.H3.16
Hydrophobic ICL2 V 691 - G.H5 L 371 G.H5.16
Polar ICL2 V 691 - G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 V 691 - G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 V 691 - G.s2s3 K 220 G.s2s3.02
Hydrophobic C-term Y 910 - G.s4h3 M 262 G.s4h3.09
Van-der-waals C-term Y 910 - G.s4h3 M 262 G.s4h3.09
Hydrophobic ICL2 V 691 - G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 V 691 - G.s2s3 K 219 G.s2s3.01
Hydrophobic ICL2 T 692 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 T 692 - G.hns1 R 56 G.hns1.03
Hydrophobic C-term A 869 - G.H3 L 285 G.H3.17
Ionic C-term K 905 - H.HD E 172 H.HD.12
Polar C-term K 905 - H.HD E 172 H.HD.12
Hydrophobic C-term K 905 - H.HD E 172 H.HD.12
Van-der-waals C-term K 905 - H.HD E 172 H.HD.12
Hydrophobic C-term I 915 - H.HA R 106 H.HA.20
Van-der-waals C-term I 915 - H.HA R 106 H.HA.20
Polar C-term Y 907 - H.hdhe Q 174 H.hdhe.02
Hydrophobic C-term Y 907 - H.hdhe Q 174 H.hdhe.02
Van-der-waals C-term Y 907 - H.hdhe Q 174 H.hdhe.02
Polar ICL2 K 688 - G.s2s3 K 219 G.s2s3.01
Hydrophobic ICL2 K 688 - G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 K 688 - G.s2s3 K 219 G.s2s3.01
Hydrophobic C-term L 876 - G.H3 T 279 G.H3.11
Hydrophobic C-term K 879 - G.s4h3 D 264 G.s4h3.11
Polar H8 K 858 8x52 G.h3s5 N 288 G.h3s5.02
Hydrophobic H8 K 858 8x52 G.h3s5 N 288 G.h3s5.02
Van-der-waals H8 K 858 8x52 G.h3s5 N 288 G.h3s5.02
Hydrophobic ICL1 R 622 12x51 G.H5 L 380 G.H5.25
Hydrophobic C-term M 872 - G.H3 F 286 G.H3.18
Hydrophobic TM6 F 784 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 F 784 6x33 G.H5 M 379 G.H5.24
Hydrophobic C-term A 865 - G.H3 L 285 G.H3.17
Van-der-waals C-term A 865 - G.H3 L 285 G.H3.17
Hydrophobic ICL3 P 781 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 P 781 - G.H5 Q 372 G.H5.17
Polar C-term S 873 - G.H2 K 237 G.H2.06
Polar C-term S 877 - G.H2 Q 236 G.H2.05
Hydrophobic C-term S 877 - G.H2 Q 236 G.H2.05
Van-der-waals C-term S 877 - G.H2 Q 236 G.H2.05
Hydrophobic ICL2 G 687 - G.H5 L 371 G.H5.16
Van-der-waals ICL2 G 687 - G.H5 L 371 G.H5.16
Polar C-term Y 910 - H.HA D 110 H.HA.24
Hydrophobic C-term Y 910 - H.HA D 110 H.HA.24
Van-der-waals C-term Y 910 - H.HA D 110 H.HA.24
Hydrophobic ICL2 V 691 - G.S3 P 222 G.S3.02
Hydrophobic H8 K 858 8x52 G.h3s5 F 287 G.h3s5.01
Hydrophobic C-term A 869 - G.H2 F 239 G.H2.08
Van-der-waals C-term A 869 - G.H2 F 239 G.H2.08
Hydrophobic H8 R 861 8x55 G.H3 L 285 G.H3.17
Polar ICL1 A 623 12x52 G.H5 L 380 G.H5.25
Hydrophobic ICL1 A 623 12x52 G.H5 L 380 G.H5.25
Van-der-waals ICL1 A 623 12x52 G.H5 L 380 G.H5.25
Polar C-term Y 907 - H.hdhe F 173 H.hdhe.01
Hydrophobic C-term Y 907 - H.hdhe F 173 H.hdhe.01
Van-der-waals C-term Y 907 - H.hdhe F 173 H.hdhe.01
Hydrophobic ICL2 K 689 - G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 K 689 - G.s2s3 K 219 G.s2s3.01
Hydrophobic C-term L 876 - G.H2 W 238 G.H2.07
Van-der-waals C-term L 876 - G.H2 W 238 G.H2.07
Hydrophobic TM6 F 784 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 F 784 6x33 G.H5 L 375 G.H5.20
Polar ICL2 T 692 - G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 T 692 - G.s2s3 K 220 G.s2s3.02
Polar ICL2 A 693 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 A 693 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 A 693 - G.hns1 R 56 G.hns1.03
Hydrophobic C-term V 908 - H.hdhe F 173 H.hdhe.01
Polar C-term Y 910 - H.HA V 107 H.HA.21
Hydrophobic C-term Y 910 - H.HA V 107 H.HA.21
Van-der-waals C-term Y 910 - H.HA V 107 H.HA.21
Hydrophobic TM3 I 680 3x54 G.H5 M 379 G.H5.24
Van-der-waals TM3 I 680 3x54 G.H5 M 379 G.H5.24
Hydrophobic C-term V 908 - H.HA L 115 H.HA.29
Hydrophobic C-term S 877 - G.H2 R 232 G.H2.01
Polar C-term V 908 - H.HD E 172 H.HD.12
Van-der-waals C-term V 908 - H.HD E 172 H.HD.12
Hydrophobic C-term M 872 - G.H3 T 279 G.H3.11
Van-der-waals C-term M 872 - G.H3 T 279 G.H3.11
Polar C-term Y 907 - H.HD S 171 H.HD.11
Hydrophobic C-term Y 907 - H.HD S 171 H.HD.11
Van-der-waals C-term Y 907 - H.HD S 171 H.HD.11
Polar C-term S 873 - G.H2 Q 236 G.H2.05
Hydrophobic C-term S 873 - G.H2 Q 236 G.H2.05
Van-der-waals C-term S 873 - G.H2 Q 236 G.H2.05