Gi2 -
mGlu7 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | K | 689 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | K | 689 | - | G.hns1 | R | 32 | G.hns1.03 |
Polar | TM3 | R | 679 | 3x53 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM3 | R | 679 | 3x53 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM3 | R | 679 | 3x53 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | H8 | F | 863 | 8x57 | G.S6 | T | 322 | G.S6.03 |
Van-der-waals | H8 | F | 863 | 8x57 | G.S6 | T | 322 | G.S6.03 |
Hydrophobic | ICL2 | I | 697 | - | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | ICL2 | I | 697 | - | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM6 | F | 784 | 6x33 | G.H5 | K | 346 | G.H5.17 |
Van-der-waals | TM6 | F | 784 | 6x33 | G.H5 | K | 346 | G.H5.17 |
Polar | ICL2 | K | 689 | - | G.S3 | H | 196 | G.S3.02 |
Van-der-waals | ICL2 | K | 689 | - | G.S3 | H | 196 | G.S3.02 |
Polar | H8 | K | 860 | 8x54 | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | H8 | K | 860 | 8x54 | G.S6 | I | 320 | G.S6.01 |
Van-der-waals | H8 | K | 860 | 8x54 | G.S6 | I | 320 | G.S6.01 |
Polar | C-term | Y | 910 | - | G.H3 | K | 249 | G.H3.07 |
Hydrophobic | C-term | Y | 910 | - | G.H3 | K | 249 | G.H3.07 |
Van-der-waals | C-term | Y | 910 | - | G.H3 | K | 249 | G.H3.07 |
Hydrophobic | TM3 | R | 679 | 3x53 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | I | 683 | 3x57 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | I | 683 | 3x57 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL1 | A | 623 | 12x52 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | ICL1 | A | 623 | 12x52 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | ICL1 | A | 623 | 12x52 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | TM3 | I | 680 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | I | 680 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Polar | TM2 | G | 625 | 2x35 | G.H5 | G | 353 | G.H5.24 |
Polar | ICL2 | K | 689 | - | G.s2s3 | D | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | K | 689 | - | G.s2s3 | D | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | K | 689 | - | G.s2s3 | D | 194 | G.s2s3.02 |
Hydrophobic | C-term | I | 915 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | C-term | I | 915 | - | G.H2 | I | 213 | G.H2.08 |
Polar | ICL2 | T | 692 | - | G.hns1 | A | 30 | G.hns1.01 |
Hydrophobic | ICL2 | T | 692 | - | G.hns1 | A | 30 | G.hns1.01 |
Van-der-waals | ICL2 | T | 692 | - | G.hns1 | A | 30 | G.hns1.01 |
Polar | ICL1 | A | 623 | 12x52 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL1 | A | 623 | 12x52 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | ICL1 | A | 623 | 12x52 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | S | 690 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | S | 690 | - | G.S3 | L | 195 | G.S3.01 |
Polar | ICL2 | T | 692 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | T | 692 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | T | 692 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM3 | F | 684 | 3x58 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM3 | F | 684 | 3x58 | G.H5 | I | 345 | G.H5.16 |
Polar | H8 | K | 860 | 8x54 | G.S5 | I | 265 | G.S5.02 |
Hydrophobic | ICL3 | V | 780 | - | G.H5 | L | 349 | G.H5.20 |
Polar | ICL2 | T | 692 | - | G.HN | G | 27 | G.HN.51 |
Van-der-waals | ICL2 | T | 692 | - | G.HN | G | 27 | G.HN.51 |
Hydrophobic | ICL2 | V | 691 | - | G.S1 | E | 33 | G.S1.01 |
Van-der-waals | ICL2 | V | 691 | - | G.S1 | E | 33 | G.S1.01 |
Hydrophobic | C-term | A | 870 | - | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | C-term | A | 870 | - | G.H5 | F | 335 | G.H5.06 |
Aromatic | H8 | K | 860 | 8x54 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | H8 | K | 860 | 8x54 | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | H8 | K | 860 | 8x54 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | ICL3 | N | 783 | - | G.H5 | K | 346 | G.H5.17 |
Van-der-waals | ICL3 | N | 783 | - | G.H5 | K | 346 | G.H5.17 |
Ionic | H8 | K | 860 | 8x54 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | H8 | K | 860 | 8x54 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | H8 | K | 860 | 8x54 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | H8 | K | 860 | 8x54 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | ICL2 | V | 691 | - | G.S3 | L | 195 | G.S3.01 |
Polar | ICL2 | S | 690 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | S | 690 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | S | 690 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | V | 691 | - | G.h2s4 | T | 220 | G.h2s4.05 |
Van-der-waals | ICL2 | V | 691 | - | G.h2s4 | T | 220 | G.h2s4.05 |
Hydrophobic | TM3 | I | 683 | 3x57 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | I | 683 | 3x57 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | ICL2 | V | 691 | - | G.S1 | V | 34 | G.S1.02 |
Van-der-waals | ICL2 | V | 691 | - | G.S1 | V | 34 | G.S1.02 |
Polar | C-term | K | 864 | - | G.H4 | S | 302 | G.H4.08 |
Hydrophobic | TM3 | I | 683 | 3x57 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | I | 683 | 3x57 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | Q | 686 | 3x60 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | K | 688 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Van-der-waals | ICL2 | K | 688 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Ionic | ICL2 | K | 688 | - | G.s2s3 | D | 194 | G.s2s3.02 |
Polar | ICL2 | K | 688 | - | G.s2s3 | D | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | K | 688 | - | G.s2s3 | D | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | K | 688 | - | G.s2s3 | D | 194 | G.s2s3.02 |
Aromatic | H8 | F | 863 | 8x57 | G.S6 | H | 323 | G.S6.04 |
Hydrophobic | H8 | F | 863 | 8x57 | G.S6 | H | 323 | G.S6.04 |
Van-der-waals | H8 | F | 863 | 8x57 | G.S6 | H | 323 | G.S6.04 |
Polar | ICL2 | K | 688 | - | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | ICL2 | K | 688 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | K | 688 | - | G.S3 | L | 195 | G.S3.01 |
Polar | ICL2 | R | 695 | - | G.HN | L | 23 | G.HN.47 |
Van-der-waals | ICL2 | R | 695 | - | G.HN | L | 23 | G.HN.47 |
Hydrophobic | TM3 | I | 683 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Ionic | H8 | R | 859 | 8x53 | G.h4s6 | D | 316 | G.h4s6.09 |
Polar | H8 | R | 859 | 8x53 | G.h4s6 | D | 316 | G.h4s6.09 |
Hydrophobic | H8 | R | 859 | 8x53 | G.h4s6 | D | 316 | G.h4s6.09 |
Van-der-waals | H8 | R | 859 | 8x53 | G.h4s6 | D | 316 | G.h4s6.09 |
Polar | ICL2 | V | 691 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | V | 691 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | V | 691 | - | G.hns1 | A | 31 | G.hns1.02 |
Polar | ICL2 | V | 691 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | H8 | F | 863 | 8x57 | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | H8 | F | 863 | 8x57 | G.S6 | Y | 321 | G.S6.02 |
Aromatic | TM6 | F | 784 | 6x33 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | TM6 | F | 784 | 6x33 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | TM6 | F | 784 | 6x33 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | ICL1 | A | 623 | 12x52 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | ICL1 | A | 623 | 12x52 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | ICL2 | A | 693 | - | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | ICL2 | G | 687 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | G | 687 | - | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | ICL2 | K | 689 | - | G.S3 | L | 195 | G.S3.01 |
Polar | TM3 | R | 679 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 679 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 679 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM6 | F | 784 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM6 | F | 784 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Polar | ICL2 | S | 690 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | S | 690 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | S | 690 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | R | 695 | - | G.HN | R | 24 | G.HN.48 |
Van-der-waals | ICL2 | R | 695 | - | G.HN | R | 24 | G.HN.48 |
Hydrophobic | H8 | R | 859 | 8x53 | G.h4s6 | K | 315 | G.h4s6.08 |
Hydrophobic | ICL3 | N | 783 | - | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | ICL3 | N | 783 | - | G.H5 | F | 355 | G.H5.26 |