Gs - mGlu7 receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 683 3x57 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 683 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM6 F 784 6x33 G.H5 R 385 G.H5.17
Polar H8 Q 857 8x51 G.H5 R 389 G.H5.21
Polar TM4 S 698 4x28 G.H5 Y 391 G.H5.23
Hydrophobic TM4 S 698 4x28 G.H5 Y 391 G.H5.23
Van-der-waals TM4 S 698 4x28 G.H5 Y 391 G.H5.23
Ionic C-term K 905 - H.HA E 87 H.HA.03
Polar C-term K 905 - H.HA E 87 H.HA.03
Van-der-waals C-term K 905 - H.HA E 87 H.HA.03
Hydrophobic ICL2 S 690 - G.S3 V 217 G.S3.01
Polar TM3 F 684 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 F 684 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 F 684 3x58 G.H5 Q 384 G.H5.16
Hydrophobic C-term P 898 - G.h1ha E 75 G.h1ha.11
Van-der-waals C-term K 864 - G.S6 F 363 G.S6.05
Polar ICL2 A 693 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 A 693 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 A 693 - G.H5 H 387 G.H5.19
Polar ICL1 A 623 12x52 G.H5 E 392 G.H5.24
Hydrophobic ICL1 A 623 12x52 G.H5 E 392 G.H5.24
Van-der-waals ICL1 A 623 12x52 G.H5 E 392 G.H5.24
Hydrophobic TM3 R 679 3x53 G.H5 L 393 G.H5.25
Van-der-waals TM3 R 679 3x53 G.H5 L 393 G.H5.25
Hydrophobic ICL2 T 692 - G.hns1 R 38 G.hns1.02
Aromatic H8 F 863 8x57 G.H5 R 385 G.H5.17
Hydrophobic H8 F 863 8x57 G.H5 R 385 G.H5.17
Van-der-waals H8 F 863 8x57 G.H5 R 385 G.H5.17
Hydrophobic ICL1 A 623 12x52 G.H5 L 393 G.H5.25
Van-der-waals ICL1 A 623 12x52 G.H5 L 393 G.H5.25
Polar C-term S 900 - G.h1ha E 75 G.h1ha.11
Hydrophobic C-term S 900 - G.h1ha E 75 G.h1ha.11
Van-der-waals C-term S 900 - G.h1ha E 75 G.h1ha.11
Hydrophobic TM3 F 684 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 F 684 3x58 G.H5 L 388 G.H5.20
Hydrophobic TM6 F 784 6x33 G.H5 L 388 G.H5.20
Van-der-waals TM6 F 784 6x33 G.H5 L 388 G.H5.20
Polar C-term N 899 - G.h1ha E 75 G.h1ha.11
Hydrophobic TM3 I 683 3x57 G.H5 L 388 G.H5.20
Polar C-term K 864 - G.S6 P 361 G.S6.03
Hydrophobic C-term K 864 - G.S6 P 361 G.S6.03
Van-der-waals C-term K 864 - G.S6 P 361 G.S6.03
Hydrophobic TM6 F 784 6x33 G.H5 L 394 G.H5.26
Van-der-waals TM6 F 784 6x33 G.H5 L 394 G.H5.26
Polar H8 R 859 8x53 G.h4s6 A 351 G.h4s6.04
Hydrophobic H8 R 859 8x53 G.h4s6 A 351 G.h4s6.04
Van-der-waals H8 R 859 8x53 G.h4s6 A 351 G.h4s6.04
Hydrophobic H8 F 863 8x57 G.H5 D 381 G.H5.13
Van-der-waals H8 F 863 8x57 G.H5 D 381 G.H5.13
Hydrophobic ICL2 G 687 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 G 687 - G.H5 R 380 G.H5.12
Polar ICL2 V 691 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 V 691 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 V 691 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 I 697 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 I 697 - G.H5 Y 391 G.H5.23
Hydrophobic C-term K 864 - G.H4 R 342 G.H4.12
Van-der-waals C-term K 864 - G.H4 R 342 G.H4.12
Hydrophobic ICL2 T 692 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 T 692 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 P 694 - G.H5 H 387 G.H5.19
Polar H8 F 863 8x57 G.S6 C 359 G.S6.01
Hydrophobic TM4 P 699 4x29 G.H5 Y 391 G.H5.23
Polar H8 R 859 8x53 G.h4s6 S 352 G.h4s6.08
Hydrophobic H8 R 859 8x53 G.h4s6 S 352 G.h4s6.08
Van-der-waals H8 R 859 8x53 G.h4s6 S 352 G.h4s6.08
Hydrophobic ICL2 V 691 - G.S3 V 217 G.S3.01
Ionic ICL1 R 622 12x51 G.H5 E 392 G.H5.24
Polar ICL1 R 622 12x51 G.H5 E 392 G.H5.24
Hydrophobic ICL1 R 622 12x51 G.H5 E 392 G.H5.24
Van-der-waals ICL1 R 622 12x51 G.H5 E 392 G.H5.24
Hydrophobic H8 R 861 8x55 G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 G 687 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 K 689 - G.S3 V 217 G.S3.01
Polar ICL2 K 688 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 K 688 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 K 688 - G.H5 R 380 G.H5.12
Hydrophobic H8 F 863 8x57 G.h4s6 Y 358 G.h4s6.20
Polar TM3 R 679 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 679 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 679 3x53 G.H5 Y 391 G.H5.23
Aromatic H8 F 863 8x57 G.S6 Y 360 G.S6.02
Hydrophobic H8 F 863 8x57 G.S6 Y 360 G.S6.02
Van-der-waals H8 F 863 8x57 G.S6 Y 360 G.S6.02
Polar H8 R 859 8x53 G.h4s6 T 350 G.h4s6.03
Hydrophobic H8 S 862 8x56 G.H4 L 346 G.H4.16
Van-der-waals H8 S 862 8x56 G.H4 L 346 G.H4.16
Polar ICL1 S 624 12x53 G.H5 E 392 G.H5.24
Ionic TM2 R 626 2x36 G.H5 E 392 G.H5.24
Polar TM2 R 626 2x36 G.H5 E 392 G.H5.24
Hydrophobic TM2 R 626 2x36 G.H5 E 392 G.H5.24
Van-der-waals TM2 R 626 2x36 G.H5 E 392 G.H5.24
Hydrophobic ICL2 V 691 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 691 - G.H5 I 383 G.H5.15
Polar H8 R 859 8x53 G.h4s6 G 353 G.h4s6.09
Hydrophobic H8 R 859 8x53 G.h4s6 G 353 G.h4s6.09
Van-der-waals H8 R 859 8x53 G.h4s6 G 353 G.h4s6.09
Polar TM2 G 625 2x35 G.H5 E 392 G.H5.24