Gi1 - BB2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 76.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 H 152 34x57 G.HN R 21 G.HN.45
Hydrophobic TM2 P 75 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 R 259 6x30 G.H5 I 344 G.H5.16
Van-der-waals TM6 R 259 6x30 G.H5 I 344 G.H5.16
Hydrophobic TM4 M 155 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 M 155 4x40 G.HN R 24 G.HN.48
Hydrophobic ICL3 P 245 - G.H5 F 334 G.H5.06
Hydrophobic ICL2 Q 149 34x54 G.HN E 28 G.HN.52
Van-der-waals ICL2 Q 149 34x54 G.HN E 28 G.HN.52
Polar H8 S 326 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 S 326 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 326 8x47 G.H5 G 352 G.H5.24
Polar ICL2 S 151 34x56 G.HN R 24 G.HN.48
Hydrophobic ICL2 S 151 34x56 G.HN R 24 G.HN.48
Van-der-waals ICL2 S 151 34x56 G.HN R 24 G.HN.48
Hydrophobic ICL2 P 145 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 L 262 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 262 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 142 3x54 G.H5 I 344 G.H5.16
Hydrophobic C-term F 371 - G.H2 I 212 G.H2.08
Van-der-waals C-term F 371 - G.H2 I 212 G.H2.08
Ionic TM6 R 259 6x30 G.H5 D 341 G.H5.13
Polar TM6 R 259 6x30 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 259 6x30 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 259 6x30 G.H5 D 341 G.H5.13
Hydrophobic TM6 L 262 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 262 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 138 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 138 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 M 146 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 M 146 34x51 G.s2s3 K 192 G.s2s3.01
Polar ICL2 S 151 34x56 G.HN G 27 G.HN.51
Hydrophobic ICL2 S 151 34x56 G.HN G 27 G.HN.51
Ionic TM4 K 156 4x41 G.HN E 28 G.HN.52
Polar TM4 K 156 4x41 G.HN E 28 G.HN.52
Van-der-waals TM4 K 156 4x41 G.HN E 28 G.HN.52
Hydrophobic ICL2 P 145 34x50 G.H5 I 344 G.H5.16
Polar TM6 N 249 6x20 G.S6 T 321 G.S6.03
Van-der-waals TM6 N 249 6x20 G.S6 T 321 G.S6.03
Hydrophobic ICL2 I 148 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 I 148 34x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 A 150 34x55 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 A 150 34x55 G.hns1 A 31 G.hns1.02
Polar TM2 N 76 2x40 G.H5 G 352 G.H5.24
Hydrophobic TM2 N 76 2x40 G.H5 G 352 G.H5.24
Ionic TM6 H 251 6x22 G.h4s6 E 318 G.h4s6.12
Polar TM6 H 251 6x22 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 H 251 6x22 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 H 251 6x22 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM2 P 75 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 P 75 2x39 G.H5 C 351 G.H5.23
Polar ICL2 S 151 34x56 G.HN E 28 G.HN.52
Hydrophobic ICL2 S 151 34x56 G.HN E 28 G.HN.52
Van-der-waals ICL2 S 151 34x56 G.HN E 28 G.HN.52
Polar ICL2 S 151 34x56 G.HN E 25 G.HN.49
Hydrophobic TM6 K 254 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 254 6x25 G.h4s6 E 318 G.h4s6.12
Polar ICL2 M 146 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 M 146 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 A 141 3x53 G.H5 I 344 G.H5.16
Van-der-waals TM3 A 141 3x53 G.H5 I 344 G.H5.16
Hydrophobic TM6 R 259 6x30 G.H5 L 348 G.H5.20
Hydrophobic ICL1 M 71 12x50 G.H5 G 352 G.H5.24
Polar TM6 Q 255 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 Q 255 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 Q 255 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 S 258 6x29 G.H5 L 348 G.H5.20
Van-der-waals TM6 S 258 6x29 G.H5 L 348 G.H5.20
Hydrophobic ICL2 M 146 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM6 T 265 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 265 6x36 G.H5 L 353 G.H5.25
Hydrophobic C-term L 373 - G.H2 R 208 G.H2.04
Hydrophobic ICL2 A 150 34x55 G.HN G 27 G.HN.51
Polar TM6 H 251 6x22 G.S6 I 319 G.S6.01
Hydrophobic TM6 H 251 6x22 G.S6 I 319 G.S6.01
Van-der-waals TM6 H 251 6x22 G.S6 I 319 G.S6.01
Polar TM6 K 254 6x25 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 K 254 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL2 Q 149 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 149 34x54 G.hns1 R 32 G.hns1.03
Polar TM6 N 249 6x20 G.H4 Q 304 G.H4.12
Van-der-waals TM6 N 249 6x20 G.H4 Q 304 G.H4.12
Polar H8 S 328 8x49 G.H5 F 354 G.H5.26
Van-der-waals H8 S 328 8x49 G.H5 F 354 G.H5.26
Hydrophobic TM2 N 76 2x40 G.H5 C 351 G.H5.23
Van-der-waals TM2 N 76 2x40 G.H5 C 351 G.H5.23
Hydrophobic ICL2 M 146 34x51 G.S2 F 191 G.S2.08
Van-der-waals ICL2 M 146 34x51 G.S2 F 191 G.S2.08
Polar TM2 N 73 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 N 73 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 73 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL2 M 146 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 M 146 34x51 G.H5 F 336 G.H5.08
Polar ICL2 D 147 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 D 147 34x52 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 D 147 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic C-term I 374 - G.H3 K 248 G.H3.07
Hydrophobic ICL2 P 145 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 145 34x50 G.H5 T 340 G.H5.12
Polar TM6 K 254 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM3 A 141 3x53 G.H5 N 347 G.H5.19
Polar TM6 H 251 6x22 G.S6 Y 320 G.S6.02
Aromatic TM6 H 251 6x22 G.S6 Y 320 G.S6.02
Hydrophobic TM6 H 251 6x22 G.S6 Y 320 G.S6.02
Van-der-waals TM6 H 251 6x22 G.S6 Y 320 G.S6.02
Hydrophobic TM6 S 258 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 S 258 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 Q 149 34x54 G.hns1 A 31 G.hns1.02
Polar ICL2 H 152 34x57 G.HN R 24 G.HN.48
Hydrophobic ICL2 H 152 34x57 G.HN R 24 G.HN.48
Van-der-waals ICL2 H 152 34x57 G.HN R 24 G.HN.48
Hydrophobic ICL2 M 146 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 M 146 34x51 G.S3 L 194 G.S3.01
Polar TM2 N 76 2x40 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 76 2x40 G.H5 D 350 G.H5.22