G12 - kisspeptin receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 148 34x51 G.H5 K 367 G.H5.12
Ionic TM5 D 242 5x76 G.S6 H 349 G.S6.04
Polar TM5 D 242 5x76 G.S6 H 349 G.S6.04
Hydrophobic TM5 D 242 5x76 G.S6 H 349 G.S6.04
Van-der-waals TM5 D 242 5x76 G.S6 H 349 G.S6.04
Hydrophobic TM5 D 242 5x76 G.S6 H 348 G.S6.03
Hydrophobic ICL2 L 148 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 148 34x51 G.H5 F 363 G.H5.08
Hydrophobic C-term L 363 - G.H3 T 279 G.H3.11
Hydrophobic TM6 L 264 6x36 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 148 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 148 34x51 G.S3 I 221 G.S3.01
Polar C-term G 367 - G.H2 Q 236 G.H2.05
Hydrophobic C-term G 367 - G.H2 Q 236 G.H2.05
Hydrophobic C-term L 363 - G.H3 L 285 G.H3.17
Van-der-waals C-term L 363 - G.H3 L 285 G.H3.17
Hydrophobic TM3 T 144 3x54 G.H5 L 375 G.H5.20
Polar TM3 R 140 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 I 378 G.H5.23
Polar ICL2 H 152 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 152 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 H 152 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 152 34x55 G.S3 I 221 G.S3.01
Hydrophobic C-term L 363 - G.H3 F 286 G.H3.18
Hydrophobic ICL2 P 147 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 147 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM6 V 261 6x33 G.H5 L 375 G.H5.20
Polar TM3 V 143 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 V 143 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 V 143 3x53 G.H5 N 374 G.H5.19
Polar C-term L 388 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term L 388 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term L 388 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term E 362 - G.H3 T 279 G.H3.11
Hydrophobic C-term L 388 - H.hdhe F 173 H.hdhe.01
Polar C-term D 394 - G.hfs2 K 209 G.hfs2.06
Hydrophobic C-term L 363 - G.H3 I 280 G.H3.12
Van-der-waals C-term L 363 - G.H3 I 280 G.H3.12
Polar C-term N 395 - G.hfs2 K 209 G.hfs2.06
Van-der-waals C-term N 395 - G.hfs2 K 209 G.hfs2.06
Polar C-term H 369 - G.H2 R 232 G.H2.01
Aromatic C-term H 369 - G.H2 R 232 G.H2.01
Hydrophobic C-term H 369 - G.H2 R 232 G.H2.01
Van-der-waals C-term H 369 - G.H2 R 232 G.H2.01
Hydrophobic TM5 L 231 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 231 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 147 34x50 G.H5 I 370 G.H5.15
Hydrophobic C-term L 366 - G.H2 W 238 G.H2.07
Polar H8 H 329 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM4 P 156 4x39 G.HN R 52 G.HN.52
Hydrophobic H8 G 327 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 G 327 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 H 152 34x55 G.S3 P 222 G.S3.02
Van-der-waals ICL2 H 152 34x55 G.S3 P 222 G.S3.02
Hydrophobic C-term L 366 - G.H3 I 280 G.H3.12
Polar TM2 T 77 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM2 T 77 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM2 T 77 2x39 G.H5 D 377 G.H5.22
Polar C-term E 362 - G.H3 N 283 G.H3.15
Hydrophobic C-term L 366 - G.H3 I 276 G.H3.08
Polar TM2 T 75 2x37 G.H5 D 377 G.H5.22
Polar C-term E 393 - G.s3h2 Q 231 G.s3h2.03
Hydrophobic C-term E 393 - G.s3h2 Q 231 G.s3h2.03
Van-der-waals C-term E 393 - G.s3h2 Q 231 G.s3h2.03
Hydrophobic C-term P 359 - G.H3 L 285 G.H3.17
Van-der-waals C-term P 359 - G.H3 L 285 G.H3.17
Hydrophobic ICL2 L 148 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 148 34x51 G.H5 I 370 G.H5.15
Polar C-term L 366 - G.H2 R 235 G.H2.04
Hydrophobic C-term L 366 - G.H2 R 235 G.H2.04
Van-der-waals C-term L 366 - G.H2 R 235 G.H2.04
Hydrophobic ICL2 L 151 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 L 151 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic C-term L 398 - G.hfs2 K 209 G.hfs2.06
Hydrophobic TM3 V 143 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 143 3x53 G.H5 I 378 G.H5.23
Polar TM5 Q 246 5x80 G.S6 H 348 G.S6.03
Hydrophobic TM5 Q 246 5x80 G.S6 H 348 G.S6.03
Van-der-waals TM5 Q 246 5x80 G.S6 H 348 G.S6.03
Polar TM5 S 243 5x77 G.S6 H 348 G.S6.03
Hydrophobic ICL2 L 148 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM5 L 231 5x65 G.H5 L 371 G.H5.16
Hydrophobic TM6 R 253 6x25 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 R 253 6x25 G.h4s6 P 345 G.h4s6.20
Hydrophobic C-term L 388 - H.HA K 114 H.HA.28
Van-der-waals C-term L 388 - H.HA K 114 H.HA.28
Hydrophobic TM3 T 144 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 T 144 3x54 G.H5 L 371 G.H5.16
Ionic ICL2 R 154 34x57 G.H5 D 377 G.H5.22
Polar ICL2 R 154 34x57 G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 154 34x57 G.H5 D 377 G.H5.22
Polar TM6 K 260 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 260 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 260 6x32 G.H5 Q 381 G.H5.26
Polar H8 S 328 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 S 328 8x48 G.H5 L 380 G.H5.25
Hydrophobic C-term L 391 - H.HA V 107 H.HA.21
Van-der-waals C-term L 391 - H.HA V 107 H.HA.21
Hydrophobic C-term L 364 - G.H2 F 239 G.H2.08
Hydrophobic TM6 L 264 6x36 G.H5 I 378 G.H5.23
Hydrophobic TM5 P 240 5x74 G.H5 F 361 G.H5.06
Van-der-waals TM5 P 240 5x74 G.H5 F 361 G.H5.06
Hydrophobic TM6 L 250 6x22 G.S6 F 347 G.S6.02
Van-der-waals TM6 L 250 6x22 G.S6 F 347 G.S6.02
Polar C-term A 396 - G.hfs2 K 209 G.hfs2.06
Van-der-waals C-term A 396 - G.hfs2 K 209 G.hfs2.06
Van-der-waals ICL2 L 151 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic C-term L 391 - H.HA R 106 H.HA.20
Hydrophobic C-term E 393 - G.hfs2 A 207 G.hfs2.04
Hydrophobic TM6 R 253 6x25 G.h4s6 K 344 G.h4s6.19
Van-der-waals TM6 R 253 6x25 G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL2 P 147 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM5 A 239 5x73 G.H5 H 364 G.H5.09
Hydrophobic TM6 V 261 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 261 6x33 G.H5 M 379 G.H5.24
Ionic ICL1 K 71 12x48 G.HN D 44 G.HN.44
Polar ICL1 K 71 12x48 G.HN D 44 G.HN.44
Polar C-term G 387 - H.HA K 114 H.HA.28
Hydrophobic C-term G 387 - H.HA K 114 H.HA.28
Hydrophobic TM6 V 257 6x29 G.H5 L 375 G.H5.20
Van-der-waals TM6 V 257 6x29 G.H5 L 375 G.H5.20
Polar C-term C 389 - H.HA D 110 H.HA.24
Hydrophobic C-term L 363 - G.h2s4 F 242 G.h2s4.01
Van-der-waals C-term L 363 - G.h2s4 F 242 G.h2s4.01
Hydrophobic ICL2 L 148 34x51 G.H5 V 366 G.H5.11
Hydrophobic C-term P 359 - G.H3 K 284 G.H3.16
Hydrophobic TM6 V 257 6x29 G.H5 M 379 G.H5.24
Hydrophobic C-term H 369 - G.s4h3 D 264 G.s4h3.11
Hydrophobic C-term L 363 - G.H3 N 283 G.H3.15
Van-der-waals C-term L 363 - G.H3 N 283 G.H3.15
Hydrophobic TM7 L 322 7x52 G.H5 L 380 G.H5.25
Van-der-waals TM7 L 322 7x52 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 151 34x54 G.S1 V 58 G.S1.02
Polar C-term P 359 - G.H3 N 283 G.H3.15
Hydrophobic C-term P 359 - G.H3 N 283 G.H3.15
Van-der-waals C-term P 359 - G.H3 N 283 G.H3.15
Hydrophobic C-term V 390 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term V 390 - G.s4h3 R 265 G.s4h3.12
Hydrophobic TM6 L 250 6x22 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 L 250 6x22 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 Q 246 5x80 G.S6 F 347 G.S6.02
Hydrophobic C-term G 367 - G.H2 R 232 G.H2.01
Van-der-waals C-term G 367 - G.H2 R 232 G.H2.01
Van-der-waals TM5 V 234 5x68 G.H5 D 368 G.H5.13
Polar TM5 Q 246 5x80 G.S6 L 346 G.S6.01
Van-der-waals TM5 Q 246 5x80 G.S6 L 346 G.S6.01
Hydrophobic TM7 A 324 7x54 G.H5 L 380 G.H5.25
Hydrophobic C-term L 366 - G.H3 T 279 G.H3.11
Van-der-waals C-term L 366 - G.H3 T 279 G.H3.11
Hydrophobic C-term V 390 - H.hdhe Q 174 H.hdhe.02
Hydrophobic TM2 I 81 2x43 G.H5 L 380 G.H5.25
Polar TM5 D 242 5x76 G.S6 F 350 G.S6.05
Hydrophobic TM5 D 242 5x76 G.S6 F 350 G.S6.05
Van-der-waals TM5 D 242 5x76 G.S6 F 350 G.S6.05
Hydrophobic C-term V 390 - G.s4h3 M 262 G.s4h3.09
Hydrophobic TM4 T 155 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 T 155 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic C-term G 367 - G.H2 R 235 G.H2.04
Hydrophobic C-term L 388 - H.HA A 111 H.HA.25
Van-der-waals C-term L 388 - H.HA A 111 H.HA.25
Hydrophobic C-term L 388 - H.HA L 115 H.HA.29
Polar TM6 R 253 6x25 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 R 253 6x25 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 R 253 6x25 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 K 260 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 260 6x32 G.H5 M 379 G.H5.24
Polar C-term C 389 - H.HA K 114 H.HA.28
Hydrophobic C-term C 389 - H.HA K 114 H.HA.28
Van-der-waals C-term C 389 - H.HA K 114 H.HA.28
Hydrophobic H8 S 328 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 S 328 8x48 G.H5 Q 381 G.H5.26
Hydrophobic C-term H 360 - G.H3 L 285 G.H3.17
Van-der-waals C-term H 360 - G.H3 L 285 G.H3.17
Hydrophobic ICL2 L 151 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 151 34x54 G.H5 I 370 G.H5.15
Polar H8 H 329 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 H 329 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 H 329 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM7 Y 323 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 323 7x53 G.H5 L 380 G.H5.25