Gi2 - LPA4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 T 236 - G.H5 I 345 G.H5.16
Hydrophobic ICL3 T 236 - G.H5 D 342 G.H5.13
Hydrophobic TM6 M 250 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 M 250 6x36 G.H5 L 354 G.H5.25
Polar TM3 R 136 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 136 3x50 G.H5 C 352 G.H5.23
Van-der-waals C-term F 370 - H.HA Q 79 H.HA.17
Polar TM6 S 238 6x24 G.H5 D 342 G.H5.13
Hydrophobic ICL2 F 144 34x51 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 F 144 34x51 G.s2s3 K 193 G.s2s3.01
Hydrophobic C-term F 370 - H.HA A 83 H.HA.21
Polar TM4 R 153 4x40 G.HN E 28 G.HN.52
Hydrophobic ICL2 R 147 34x54 G.H5 I 344 G.H5.15
Polar TM2 S 72 2x37 G.H5 D 351 G.H5.22
Hydrophobic TM2 S 72 2x37 G.H5 D 351 G.H5.22
Van-der-waals TM2 S 72 2x37 G.H5 D 351 G.H5.22
Hydrophobic H8 L 315 8x47 G.H5 C 352 G.H5.23
Hydrophobic TM6 V 247 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 V 247 6x33 G.H5 L 349 G.H5.20
Hydrophobic TM6 N 243 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 N 243 6x29 G.H5 F 355 G.H5.26
Hydrophobic ICL2 F 144 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 F 144 34x51 G.H5 T 341 G.H5.12
Polar TM7 T 314 7x56 G.H5 G 353 G.H5.24
Hydrophobic TM7 T 314 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 T 314 7x56 G.H5 G 353 G.H5.24
Ionic H8 E 316 8x48 G.H5 K 350 G.H5.21
Polar H8 E 316 8x48 G.H5 K 350 G.H5.21
Hydrophobic H8 E 316 8x48 G.H5 K 350 G.H5.21
Van-der-waals H8 E 316 8x48 G.H5 K 350 G.H5.21
Hydrophobic ICL2 F 144 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 F 144 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM6 Q 239 6x25 G.S6 Y 321 G.S6.02
Van-der-waals TM6 Q 239 6x25 G.S6 Y 321 G.S6.02
Hydrophobic TM4 T 151 4x38 G.HN E 28 G.HN.52
Hydrophobic TM6 V 247 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 V 247 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 V 247 6x33 G.H5 F 355 G.H5.26
Hydrophobic TM6 I 240 6x26 G.H5 K 346 G.H5.17
Hydrophobic TM3 I 140 3x54 G.H5 I 345 G.H5.16
Polar ICL2 R 147 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 147 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 147 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL3 L 237 - G.H5 L 349 G.H5.20
Van-der-waals ICL3 L 237 - G.H5 L 349 G.H5.20
Hydrophobic TM6 H 254 6x40 G.H5 L 354 G.H5.25
Van-der-waals TM6 H 254 6x40 G.H5 L 354 G.H5.25
Polar TM4 R 152 4x39 G.HN R 24 G.HN.48
Hydrophobic TM4 R 152 4x39 G.HN R 24 G.HN.48
Van-der-waals TM4 R 152 4x39 G.HN R 24 G.HN.48
Polar ICL2 R 150 34x57 G.H5 N 348 G.H5.19
Hydrophobic ICL2 F 144 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 F 144 34x51 G.H5 I 344 G.H5.15
Hydrophobic TM3 A 139 3x53 G.H5 C 352 G.H5.23
Polar ICL2 P 143 34x50 G.H5 N 348 G.H5.19
Hydrophobic TM5 L 231 5x65 G.H5 L 349 G.H5.20
Hydrophobic ICL2 R 147 34x54 G.S1 V 34 G.S1.02
Van-der-waals ICL2 R 147 34x54 G.S1 V 34 G.S1.02
Polar TM3 D 135 3x49 G.H5 C 352 G.H5.23
Polar TM6 K 246 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM6 K 246 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 K 246 6x32 G.H5 F 355 G.H5.26
Hydrophobic ICL2 R 147 34x54 G.S3 L 195 G.S3.01
Van-der-waals ICL2 R 147 34x54 G.S3 L 195 G.S3.01
Hydrophobic C-term I 349 - G.H2 K 210 G.H2.05
Van-der-waals C-term I 349 - G.H2 K 210 G.H2.05
Polar ICL2 R 147 34x54 G.S1 E 33 G.S1.01
Hydrophobic TM6 I 251 6x37 G.H5 L 354 G.H5.25
Polar ICL3 L 237 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 L 237 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 L 237 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 L 237 - G.H5 I 345 G.H5.16
Van-der-waals ICL3 L 237 - G.H5 I 345 G.H5.16
Polar TM2 T 74 2x39 G.H5 C 352 G.H5.23
Hydrophobic TM2 T 74 2x39 G.H5 C 352 G.H5.23
Hydrophobic H8 L 315 8x47 G.H5 G 353 G.H5.24
Polar TM6 I 240 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 I 240 6x26 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 I 240 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 I 240 6x26 G.H5 F 355 G.H5.26
Van-der-waals TM6 I 240 6x26 G.H5 F 355 G.H5.26
Hydrophobic ICL2 P 143 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM3 I 140 3x54 G.H5 L 354 G.H5.25
Hydrophobic TM3 I 140 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 140 3x54 G.H5 L 349 G.H5.20
Polar TM6 Q 239 6x25 G.S6 H 323 G.S6.04
Hydrophobic TM6 Q 239 6x25 G.S6 H 323 G.S6.04
Van-der-waals TM6 Q 239 6x25 G.S6 H 323 G.S6.04
Hydrophobic TM3 R 136 3x50 G.H5 L 354 G.H5.25
Polar ICL2 T 148 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 148 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 148 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 R 150 34x57 G.H5 C 352 G.H5.23
Ionic H8 K 320 8x52 G.h3s5 D 262 G.h3s5.02
Polar H8 K 320 8x52 G.h3s5 D 262 G.h3s5.02
Hydrophobic H8 K 320 8x52 G.h3s5 D 262 G.h3s5.02
Van-der-waals H8 K 320 8x52 G.h3s5 D 262 G.h3s5.02
Hydrophobic C-term L 364 - G.hfs2 V 180 G.hfs2.03
Ionic ICL2 R 145 34x52 G.s2s3 D 194 G.s2s3.02
Polar ICL2 R 145 34x52 G.s2s3 D 194 G.s2s3.02
Hydrophobic ICL2 R 145 34x52 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 R 145 34x52 G.s2s3 D 194 G.s2s3.02
Hydrophobic TM6 M 250 6x36 G.H5 G 353 G.H5.24
Van-der-waals TM6 M 250 6x36 G.H5 G 353 G.H5.24
Van-der-waals TM4 R 153 4x40 G.HN R 24 G.HN.48
Polar C-term Q 350 - G.H2 K 210 G.H2.05
Van-der-waals C-term Q 350 - G.H2 K 210 G.H2.05
Hydrophobic TM6 Q 239 6x25 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 Q 239 6x25 G.h4s6 E 319 G.h4s6.12
Ionic C-term E 367 - G.hfs2 K 181 G.hfs2.04
Polar C-term E 367 - G.hfs2 K 181 G.hfs2.04
Hydrophobic C-term E 367 - G.hfs2 K 181 G.hfs2.04
Van-der-waals C-term E 367 - G.hfs2 K 181 G.hfs2.04
Polar TM3 A 139 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 139 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 139 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM6 I 240 6x26 G.S6 Y 321 G.S6.02
Van-der-waals TM6 I 240 6x26 G.S6 Y 321 G.S6.02
Aromatic C-term F 370 - H.HA K 86 H.HA.24
Hydrophobic C-term F 370 - H.HA K 86 H.HA.24
Van-der-waals C-term F 370 - H.HA K 86 H.HA.24
Polar TM6 Q 239 6x25 G.S6 T 322 G.S6.03
Van-der-waals TM6 Q 239 6x25 G.S6 T 322 G.S6.03
Polar TM2 T 74 2x39 G.H5 D 351 G.H5.22
Hydrophobic ICL2 P 143 34x50 G.H5 I 345 G.H5.16