Gs - LH receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic H8 T 627 8x47 G.H5 E 392 G.H5.24
Polar TM3 R 464 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 464 3x50 G.H5 Y 391 G.H5.23
Polar ICL3 L 558 - G.H5 R 385 G.H5.17
Hydrophobic C-term S 657 - G.H3 W 281 G.H3.17
Van-der-waals C-term S 657 - G.H3 W 281 G.H3.17
Polar ICL2 I 472 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 I 472 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 I 472 - G.S1 H 41 G.S1.02
Polar TM5 A 552 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 I 549 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM3 T 467 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 A 471 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 A 471 - G.H5 Q 384 G.H5.16
Polar ICL2 H 473 - G.s2s3 D 215 G.s2s3.01
Hydrophobic TM3 I 468 3x54 G.H5 H 387 G.H5.19
Polar ICL3 N 555 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 N 555 - G.H5 D 381 G.H5.13
Polar TM6 K 563 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 K 563 6x29 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 K 563 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM2 P 394 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 I 472 - G.S3 F 219 G.S3.03
Hydrophobic ICL2 H 473 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 H 473 - G.S3 V 217 G.S3.01
Hydrophobic TM6 L 574 6x40 G.H5 L 393 G.H5.25
Polar TM4 R 479 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM4 R 479 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 R 479 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM6 K 570 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 468 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 474 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 L 474 - G.hns1 R 38 G.hns1.02
Hydrophobic TM6 M 571 6x37 G.H5 L 393 G.H5.25
Polar TM3 E 463 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 463 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 463 3x49 G.H5 Y 391 G.H5.23
Polar TM3 I 468 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 468 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 468 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 K 477 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 I 472 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 I 472 - G.H5 F 376 G.H5.08
Van-der-waals TM6 I 567 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 D 475 - G.hns1 A 39 G.hns1.03
Polar C-term N 662 - G.h2s4 N 239 G.h2s4.02
Van-der-waals C-term N 662 - G.h2s4 N 239 G.h2s4.02
Hydrophobic TM6 I 567 6x33 G.H5 L 394 G.H5.26
Van-der-waals TM6 I 567 6x33 G.H5 L 394 G.H5.26
Hydrophobic ICL2 A 471 - G.H5 H 387 G.H5.19
Hydrophobic TM6 I 567 6x33 G.H5 L 388 G.H5.20
Hydrophobic ICL3 L 558 - G.S6 P 361 G.S6.03
Hydrophobic ICL3 L 558 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 L 558 - G.S6 Y 360 G.S6.02
Van-der-waals TM6 K 563 6x29 G.h4s6 G 355 G.h4s6.11
Hydrophobic ICL2 I 472 - G.H5 C 379 G.H5.11
Hydrophobic ICL2 I 472 - G.S3 V 217 G.S3.01
Hydrophobic TM6 K 566 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 566 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 M 571 6x37 G.H5 L 388 G.H5.20
Hydrophobic ICL2 I 472 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 474 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 474 - G.S1 H 41 G.S1.02
Hydrophobic TM6 K 570 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 474 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 A 471 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 471 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 I 472 - G.H5 R 380 G.H5.12
Hydrophobic TM5 V 553 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 553 5x65 G.H5 L 388 G.H5.20
Polar TM3 T 467 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 T 467 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 468 3x54 G.H5 Y 391 G.H5.23
Ionic H8 K 628 8x48 G.H5 E 392 G.H5.24
Polar H8 K 628 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 628 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 628 8x48 G.H5 E 392 G.H5.24