Gi3 -
BLT1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM2 | T | 53 | 2x39 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | TM2 | T | 53 | 2x39 | G.H5 | E | 350 | G.H5.22 |
Polar | TM3 | D | 114 | 3x49 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL3 | F | 213 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | F | 213 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | F | 213 | - | G.H5 | I | 344 | G.H5.16 |
Ionic | C-term | R | 316 | - | G.HN | D | 26 | G.HN.50 |
Polar | C-term | R | 316 | - | G.HN | D | 26 | G.HN.50 |
Van-der-waals | C-term | R | 316 | - | G.HN | D | 26 | G.HN.50 |
Polar | ICL3 | R | 212 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | R | 212 | - | G.H5 | D | 341 | G.H5.13 |
Polar | C-term | T | 315 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Van-der-waals | C-term | T | 315 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | TM5 | I | 204 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | L | 208 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL3 | F | 213 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | F | 213 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | C-term | R | 316 | - | G.HN | L | 23 | G.HN.47 |
Van-der-waals | C-term | R | 316 | - | G.HN | L | 23 | G.HN.47 |
Ionic | ICL2 | R | 129 | 34x57 | G.H5 | E | 350 | G.H5.22 |
Polar | ICL2 | R | 129 | 34x57 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | ICL2 | R | 129 | 34x57 | G.H5 | E | 350 | G.H5.22 |
Polar | ICL3 | R | 214 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | R | 214 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | R | 214 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | T | 219 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | T | 219 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | T | 219 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM4 | A | 132 | 4x40 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM6 | V | 223 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | V | 223 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Polar | TM3 | A | 118 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 118 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 118 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Polar | C-term | R | 316 | - | G.HN | I | 19 | G.HN.43 |
Van-der-waals | C-term | R | 316 | - | G.HN | I | 19 | G.HN.43 |
Hydrophobic | ICL2 | F | 123 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | F | 123 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Polar | C-term | P | 336 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | TM2 | T | 53 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL3 | F | 213 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | F | 123 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | F | 123 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | ICL2 | Q | 126 | 34x54 | G.H5 | I | 343 | G.H5.15 |
Ionic | TM5 | R | 211 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | R | 211 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | R | 211 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | R | 211 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | L | 340 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | TM3 | V | 119 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 119 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL2 | Q | 126 | 34x54 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | Q | 126 | 34x54 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | Q | 126 | 34x54 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | P | 122 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM5 | R | 211 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | R | 211 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM3 | R | 115 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 115 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | T | 308 | - | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | C-term | T | 308 | - | G.H5 | K | 349 | G.H5.21 |
Hydrophobic | TM3 | A | 118 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | A | 118 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | F | 123 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Polar | ICL2 | R | 129 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | R | 129 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | ICL2 | R | 129 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | P | 122 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Polar | C-term | T | 308 | - | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | C-term | T | 308 | - | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | C-term | T | 308 | - | G.H5 | E | 350 | G.H5.22 |
Polar | C-term | S | 310 | - | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | C-term | S | 310 | - | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | C-term | S | 310 | - | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | ICL2 | K | 127 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM5 | R | 211 | 5x68 | G.H5 | T | 340 | G.H5.12 |
Polar | C-term | E | 338 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | C-term | E | 338 | - | G.H2 | K | 209 | G.H2.05 |
Van-der-waals | C-term | E | 338 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | ICL2 | P | 122 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM5 | L | 208 | 5x65 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | F | 123 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | F | 123 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | C-term | L | 340 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | TM4 | T | 130 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM3 | V | 119 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | S | 216 | 6x30 | G.H5 | Y | 354 | G.H5.26 |
Polar | TM3 | R | 115 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 115 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 115 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Polar | C-term | R | 316 | - | G.HN | N | 22 | G.HN.46 |
Hydrophobic | C-term | R | 316 | - | G.HN | N | 22 | G.HN.46 |
Van-der-waals | C-term | R | 316 | - | G.HN | N | 22 | G.HN.46 |
Hydrophobic | C-term | T | 308 | - | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | C-term | T | 308 | - | G.H5 | G | 352 | G.H5.24 |
Polar | TM3 | R | 115 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | L | 222 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | Y | 201 | 5x58 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL2 | P | 122 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | P | 122 | 34x50 | G.H5 | N | 347 | G.H5.19 |