GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 73.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 15.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL3 | Q | 256 | - | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | ICL3 | Q | 256 | - | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | ICL3 | Q | 256 | - | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | TM3 | V | 175 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM3 | V | 175 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Polar | ICL2 | C | 183 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | C | 183 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | C | 183 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | I | 179 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | I | 179 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | TM7 | F | 315 | 7x54 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | F | 315 | 7x54 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | R | 261 | 6x32 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM6 | R | 261 | 6x32 | G.H5 | Q | 381 | G.H5.26 |
Polar | TM3 | C | 174 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | C | 174 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | C | 174 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL2 | P | 178 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | P | 178 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM3 | C | 174 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | C | 174 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Polar | ICL2 | H | 184 | 34x56 | G.hns1 | R | 56 | G.hns1.03 |
Aromatic | ICL2 | H | 184 | 34x56 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | C-term | L | 368 | - | G.h1ha | R | 83 | G.h1ha.02 |
Van-der-waals | C-term | L | 368 | - | G.h1ha | R | 83 | G.h1ha.02 |
Van-der-waals | ICL3 | Q | 256 | - | G.S6 | F | 347 | G.S6.02 |
Ionic | C-term | D | 339 | - | G.HN | R | 51 | G.HN.51 |
Polar | C-term | D | 339 | - | G.HN | R | 51 | G.HN.51 |
Hydrophobic | C-term | D | 339 | - | G.HN | R | 51 | G.HN.51 |
Van-der-waals | C-term | D | 339 | - | G.HN | R | 51 | G.HN.51 |
Polar | C-term | L | 367 | - | G.h1ha | R | 83 | G.h1ha.02 |
Hydrophobic | H8 | G | 318 | 8x47 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | H8 | G | 318 | 8x47 | G.H5 | M | 379 | G.H5.24 |
Polar | C-term | H | 372 | - | G.S2 | E | 213 | G.S2.03 |
Van-der-waals | C-term | H | 372 | - | G.S2 | E | 213 | G.S2.03 |
Hydrophobic | ICL2 | P | 178 | 34x50 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM6 | V | 262 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM6 | V | 262 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Ionic | C-term | E | 371 | - | G.S2 | H | 214 | G.S2.04 |
Polar | C-term | E | 371 | - | G.S2 | H | 214 | G.S2.04 |
Hydrophobic | C-term | E | 371 | - | G.S2 | H | 214 | G.S2.04 |
Van-der-waals | C-term | E | 371 | - | G.S2 | H | 214 | G.S2.04 |
Polar | H8 | S | 319 | 8x48 | G.H5 | M | 379 | G.H5.24 |
Polar | ICL2 | P | 178 | 34x50 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | P | 178 | 34x50 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | C-term | R | 373 | - | G.S2 | V | 212 | G.S2.02 |
Hydrophobic | C-term | V | 376 | - | G.H2 | Q | 240 | G.H2.09 |
Van-der-waals | C-term | V | 376 | - | G.H2 | Q | 240 | G.H2.09 |
Hydrophobic | TM4 | K | 187 | 4x39 | G.HN | R | 52 | G.HN.52 |
Van-der-waals | TM4 | K | 187 | 4x39 | G.HN | R | 52 | G.HN.52 |
Polar | ICL2 | H | 184 | 34x56 | G.s2s3 | K | 220 | G.s2s3.02 |
Hydrophobic | ICL2 | H | 184 | 34x56 | G.s2s3 | K | 220 | G.s2s3.02 |
Van-der-waals | ICL2 | H | 184 | 34x56 | G.s2s3 | K | 220 | G.s2s3.02 |
Hydrophobic | C-term | V | 376 | - | G.S2 | I | 211 | G.S2.01 |
Hydrophobic | TM6 | A | 259 | 6x30 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | R | 182 | 34x54 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | R | 182 | 34x54 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM3 | R | 171 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 171 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM6 | R | 261 | 6x32 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | R | 261 | 6x32 | G.H5 | M | 379 | G.H5.24 |
Polar | C-term | V | 374 | - | G.S2 | I | 211 | G.S2.01 |
Hydrophobic | ICL2 | I | 179 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Polar | TM4 | Y | 188 | 4x40 | G.HN | R | 52 | G.HN.52 |
Hydrophobic | TM4 | Y | 188 | 4x40 | G.HN | R | 52 | G.HN.52 |
Van-der-waals | TM4 | Y | 188 | 4x40 | G.HN | R | 52 | G.HN.52 |
Polar | H8 | K | 322 | 8x51 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | H8 | K | 322 | 8x51 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | K | 322 | 8x51 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | C-term | P | 369 | - | G.h1ha | R | 83 | G.h1ha.02 |
Van-der-waals | C-term | P | 369 | - | G.h1ha | R | 83 | G.h1ha.02 |
Polar | TM2 | Y | 108 | 2x39 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM2 | Y | 108 | 2x39 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM2 | Y | 108 | 2x39 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM2 | Y | 108 | 2x39 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | H | 184 | 34x56 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | TM7 | V | 317 | 7x56 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL2 | I | 179 | 34x51 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM6 | V | 265 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | V | 265 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM3 | V | 175 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL3 | K | 258 | - | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | ICL3 | K | 258 | - | G.H5 | Q | 372 | G.H5.17 |
Ionic | ICL2 | R | 182 | 34x54 | G.H5 | E | 373 | G.H5.18 |
Polar | ICL2 | R | 182 | 34x54 | G.H5 | E | 373 | G.H5.18 |
Hydrophobic | ICL2 | R | 182 | 34x54 | G.H5 | E | 373 | G.H5.18 |
Van-der-waals | ICL2 | R | 182 | 34x54 | G.H5 | E | 373 | G.H5.18 |
Ionic | C-term | E | 371 | - | G.H1 | R | 78 | G.H1.09 |
Polar | C-term | E | 371 | - | G.H1 | R | 78 | G.H1.09 |
Van-der-waals | C-term | E | 371 | - | G.H1 | R | 78 | G.H1.09 |
Polar | TM2 | N | 106 | 2x37 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM2 | N | 106 | 2x37 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | TM2 | N | 106 | 2x37 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | ICL3 | K | 258 | - | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | ICL3 | K | 258 | - | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | ICL2 | P | 178 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | ICL2 | P | 178 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM6 | V | 262 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | V | 262 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM2 | M | 109 | 2x40 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM2 | M | 109 | 2x40 | G.H5 | L | 380 | G.H5.25 |
Polar | H8 | S | 319 | 8x48 | G.H5 | L | 380 | G.H5.25 |
Polar | H8 | G | 318 | 8x47 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | H8 | G | 318 | 8x47 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | G | 318 | 8x47 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | ICL2 | Y | 181 | 34x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL2 | I | 179 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | I | 179 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | C-term | E | 371 | - | G.S2 | V | 212 | G.S2.02 |