Gs - MAS1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 25.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic C-term D 305 - G.H5 R 389 G.H5.21
Polar C-term D 305 - G.H5 R 389 G.H5.21
Hydrophobic C-term D 305 - G.H5 R 389 G.H5.21
Van-der-waals C-term D 305 - G.H5 R 389 G.H5.21
Polar TM2 N 64 2x37 G.H5 E 392 G.H5.24
Van-der-waals TM2 N 64 2x37 G.H5 E 392 G.H5.24
Hydrophobic ICL2 Y 140 34x53 G.H5 L 393 G.H5.25
Polar ICL2 R 141 34x54 G.H5 H 387 G.H5.19
Aromatic ICL2 R 141 34x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 R 141 34x54 G.H5 H 387 G.H5.19
Van-der-waals ICL2 R 141 34x54 G.H5 H 387 G.H5.19
Polar C-term F 303 - G.H5 L 393 G.H5.25
Van-der-waals C-term F 303 - G.H5 L 393 G.H5.25
Hydrophobic C-term M 307 - G.H5 L 388 G.H5.20
Polar ICL3 S 221 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 S 221 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 S 221 - G.h4s6 Y 358 G.h4s6.20
Polar C-term Q 308 - G.S5 S 286 G.S5.01
Hydrophobic ICL2 R 141 34x54 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 R 141 34x54 G.hns1 A 39 G.hns1.03
Polar TM4 K 146 4x39 G.HN Q 35 G.HN.52
Hydrophobic TM4 K 146 4x39 G.HN Q 35 G.HN.52
Van-der-waals TM4 K 146 4x39 G.HN Q 35 G.HN.52
Polar C-term T 300 - G.H5 E 392 G.H5.24
Hydrophobic C-term T 300 - G.H5 E 392 G.H5.24
Van-der-waals C-term T 300 - G.H5 E 392 G.H5.24
Polar ICL3 H 222 - G.h4s6 G 355 G.h4s6.11
Hydrophobic ICL3 H 222 - G.h4s6 G 355 G.h4s6.11
Van-der-waals ICL3 H 222 - G.h4s6 G 355 G.h4s6.11
Polar ICL3 H 222 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 H 222 - G.h4s6 Y 358 G.h4s6.20
Ionic TM5 K 213 5x62 G.H5 D 381 G.H5.13
Polar TM5 K 213 5x62 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 213 5x62 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 213 5x62 G.H5 D 381 G.H5.13
Hydrophobic TM2 N 64 2x37 G.H5 L 393 G.H5.25
Van-der-waals TM2 N 64 2x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 137 34x50 G.H5 L 388 G.H5.20
Polar TM2 N 64 2x37 G.H5 Y 391 G.H5.23
Van-der-waals TM2 N 64 2x37 G.H5 Y 391 G.H5.23
Polar ICL2 C 142 34x55 G.S3 N 218 G.S3.02
Polar ICL2 C 142 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 C 142 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 C 142 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM3 S 133 3x53 G.H5 L 388 G.H5.20
Van-der-waals TM3 S 133 3x53 G.H5 L 388 G.H5.20
Hydrophobic ICL3 A 220 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 A 220 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL1 R 62 - G.HN K 34 G.HN.51
Hydrophobic TM3 V 134 3x54 G.H5 L 394 G.H5.26
Van-der-waals TM3 V 134 3x54 G.H5 L 394 G.H5.26
Polar ICL2 R 141 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 R 141 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 R 141 34x54 G.S1 H 41 G.S1.02
Hydrophobic C-term K 304 - G.H5 L 394 G.H5.26
Van-der-waals C-term K 304 - G.H5 L 394 G.H5.26
Polar ICL2 H 143 34x56 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 H 143 34x56 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 H 143 34x56 G.s2s3 D 215 G.s2s3.01
Van-der-waals TM5 W 219 5x68 G.hgh4 D 323 G.hgh4.13
Ionic H8 K 288 8x51 G.h4s6 D 354 G.h4s6.10
Polar H8 K 288 8x51 G.h4s6 D 354 G.h4s6.10
Hydrophobic H8 K 288 8x51 G.h4s6 D 354 G.h4s6.10
Van-der-waals H8 K 288 8x51 G.h4s6 D 354 G.h4s6.10
Hydrophobic ICL3 A 220 - G.S6 Y 360 G.S6.02
Hydrophobic TM3 S 133 3x53 G.H5 L 394 G.H5.26
Van-der-waals TM3 S 133 3x53 G.H5 L 394 G.H5.26
Polar TM5 K 213 5x62 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 213 5x62 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 213 5x62 G.H5 R 385 G.H5.17
Hydrophobic TM1 M 61 1x61 G.H5 E 392 G.H5.24
Van-der-waals TM1 M 61 1x61 G.H5 E 392 G.H5.24
Hydrophobic ICL3 H 222 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term Q 308 - G.h4s6 H 357 G.h4s6.13
Van-der-waals C-term Q 308 - G.h4s6 H 357 G.h4s6.13
Hydrophobic ICL2 C 142 34x55 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 C 142 34x55 G.s2s3 K 216 G.s2s3.02
Polar C-term Q 308 - G.H5 R 389 G.H5.21
Hydrophobic C-term Q 308 - G.H5 R 389 G.H5.21
Van-der-waals C-term Q 308 - G.H5 R 389 G.H5.21
Hydrophobic C-term F 303 - G.H5 E 392 G.H5.24
Van-der-waals C-term F 303 - G.H5 E 392 G.H5.24
Polar ICL3 S 221 - G.h4s6 G 355 G.h4s6.11
Hydrophobic ICL3 S 221 - G.h4s6 G 355 G.h4s6.11
Van-der-waals ICL3 S 221 - G.h4s6 G 355 G.h4s6.11
Polar C-term M 307 - G.H5 L 394 G.H5.26
Hydrophobic C-term M 307 - G.H5 L 394 G.H5.26
Van-der-waals C-term M 307 - G.H5 L 394 G.H5.26
Hydrophobic C-term P 309 - G.h4s6 Y 358 G.h4s6.20
Polar C-term K 304 - G.H5 R 389 G.H5.21
Hydrophobic C-term K 304 - G.H5 R 389 G.H5.21
Van-der-waals C-term K 304 - G.H5 R 389 G.H5.21
Hydrophobic TM2 P 65 2x38 G.H5 L 393 G.H5.25
Hydrophobic ICL2 Y 140 34x53 G.H5 L 388 G.H5.20
Hydrophobic ICL2 H 143 34x56 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 H 143 34x56 G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 C 142 34x55 G.S3 V 217 G.S3.01
Van-der-waals ICL2 C 142 34x55 G.S3 V 217 G.S3.01
Hydrophobic ICL2 R 141 34x54 G.H5 L 388 G.H5.20
Van-der-waals ICL2 R 141 34x54 G.H5 L 388 G.H5.20
Hydrophobic C-term M 307 - G.H5 R 385 G.H5.17
Van-der-waals C-term M 307 - G.H5 R 385 G.H5.17
Hydrophobic H8 K 288 8x51 G.h4s6 R 356 G.h4s6.12
Polar ICL1 R 63 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 R 63 - G.hns1 R 38 G.hns1.02
Polar C-term R 311 - G.h4s6 S 349 G.h4s6.02
Van-der-waals C-term R 311 - G.h4s6 S 349 G.h4s6.02
Polar C-term F 303 - G.H5 L 394 G.H5.26
Hydrophobic C-term F 303 - G.H5 L 394 G.H5.26
Van-der-waals C-term F 303 - G.H5 L 394 G.H5.26
Hydrophobic ICL2 I 138 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 I 138 34x51 G.H5 R 380 G.H5.12
Van-der-waals C-term Q 308 - G.h4s6 G 355 G.h4s6.11
Polar C-term Q 308 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic C-term Q 308 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals C-term Q 308 - G.h4s6 Y 358 G.h4s6.20
Polar ICL3 H 222 - G.H5 R 389 G.H5.21
Hydrophobic ICL2 I 138 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 I 138 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 I 138 34x51 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 I 138 34x51 G.s2s3 D 215 G.s2s3.01
Ionic C-term K 304 - G.H5 E 392 G.H5.24
Hydrophobic C-term K 304 - G.H5 E 392 G.H5.24
Van-der-waals C-term K 304 - G.H5 E 392 G.H5.24
Hydrophobic C-term M 307 - G.H5 R 389 G.H5.21
Van-der-waals C-term M 307 - G.H5 R 389 G.H5.21
Polar C-term K 304 - G.H5 Q 390 G.H5.22
Hydrophobic C-term K 304 - G.H5 Q 390 G.H5.22
Van-der-waals C-term K 304 - G.H5 Q 390 G.H5.22
Polar ICL2 R 141 34x54 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 R 141 34x54 G.H5 Q 384 G.H5.16
Hydrophobic TM5 N 217 5x66 G.H5 R 385 G.H5.17
Polar C-term R 311 - G.h4s6 T 350 G.h4s6.03
Hydrophobic C-term R 311 - G.h4s6 T 350 G.h4s6.03
Van-der-waals C-term R 311 - G.h4s6 T 350 G.h4s6.03
Polar ICL1 R 62 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL1 R 62 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 R 62 - G.hns1 R 38 G.hns1.02
Polar C-term D 305 - G.H5 L 394 G.H5.26
Hydrophobic C-term D 305 - G.H5 L 394 G.H5.26
Van-der-waals C-term D 305 - G.H5 L 394 G.H5.26
Polar ICL2 I 138 34x51 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 I 138 34x51 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 I 138 34x51 G.H5 Q 384 G.H5.16
Polar TM4 K 146 4x39 G.HN Q 31 G.HN.48
Hydrophobic TM2 F 66 2x39 G.H5 L 393 G.H5.25
Polar C-term Q 308 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term Q 308 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term Q 308 - G.h4s6 R 356 G.h4s6.12
Polar C-term E 306 - G.H5 R 389 G.H5.21
Van-der-waals C-term E 306 - G.H5 R 389 G.H5.21
Polar C-term E 306 - G.H5 L 394 G.H5.26
Hydrophobic C-term E 306 - G.H5 L 394 G.H5.26
Van-der-waals C-term E 306 - G.H5 L 394 G.H5.26
Hydrophobic ICL2 P 137 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 137 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM6 L 226 6x33 G.H5 L 394 G.H5.26