G12 - MC5 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 H 215 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 H 215 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 148 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM6 T 232 6x29 G.H5 L 380 G.H5.25
Polar ICL1 N 66 12x49 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 A 212 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 A 212 5x65 G.H5 L 375 G.H5.20
Polar ICL2 H 151 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 H 151 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 H 151 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 Q 235 6x32 G.H5 L 380 G.H5.25
Van-der-waals TM6 Q 235 6x32 G.H5 L 380 G.H5.25
Polar ICL2 R 149 34x52 G.s2s3 K 219 G.s2s3.01
Hydrophobic ICL2 R 149 34x52 G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 R 149 34x52 G.s2s3 K 219 G.s2s3.01
Polar H8 S 299 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 S 299 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 S 299 8x47 G.H5 Q 381 G.H5.26
Hydrophobic ICL3 A 225 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 L 148 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 148 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM5 H 215 5x68 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 R 149 34x52 G.S3 I 221 G.S3.01
Van-der-waals ICL2 R 149 34x52 G.S3 I 221 G.S3.01
Hydrophobic ICL2 L 148 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 148 34x51 G.H5 I 370 G.H5.15
Polar TM7 R 298 7x56 G.H5 Q 381 G.H5.26
Hydrophobic TM7 R 298 7x56 G.H5 Q 381 G.H5.26
Van-der-waals TM7 R 298 7x56 G.H5 Q 381 G.H5.26
Hydrophobic TM3 I 144 3x54 G.H5 I 378 G.H5.23
Polar ICL2 H 151 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 151 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 H 151 34x54 G.hns1 R 56 G.hns1.03
Polar TM7 R 298 7x56 G.H5 M 379 G.H5.24
Hydrophobic TM7 R 298 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 R 298 7x56 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 148 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 148 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM5 M 208 5x61 G.H5 M 379 G.H5.24
Hydrophobic TM3 I 144 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 144 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM3 R 140 3x50 G.H5 I 378 G.H5.23
Hydrophobic H8 Q 300 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 Q 300 8x48 G.H5 Q 381 G.H5.26
Van-der-waals TM3 T 143 3x53 G.H5 I 378 G.H5.23
Polar TM6 T 239 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM6 T 239 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 239 6x36 G.H5 M 379 G.H5.24
Polar TM3 T 143 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 T 143 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM5 I 219 5x72 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 I 219 5x72 G.h4s6 P 345 G.h4s6.20
Ionic TM5 H 215 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 215 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 215 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 215 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM6 G 236 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 G 236 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM4 T 155 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 T 155 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 A 212 5x65 G.H5 M 379 G.H5.24
Van-der-waals TM5 A 212 5x65 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 148 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM5 I 219 5x72 G.H5 Q 372 G.H5.17
Hydrophobic TM3 I 144 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 144 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 148 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM5 L 211 5x64 G.H5 L 371 G.H5.16
Polar TM7 R 298 7x56 G.H5 I 378 G.H5.23
Hydrophobic ICL3 L 222 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 L 222 - G.S6 F 347 G.S6.02
Hydrophobic TM5 F 209 5x62 G.H5 M 379 G.H5.24
Hydrophobic ICL2 A 147 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL3 P 223 - G.S6 H 348 G.S6.03
Polar H8 R 303 8x51 G.H5 Q 381 G.H5.26
Hydrophobic H8 R 303 8x51 G.H5 Q 381 G.H5.26
Van-der-waals H8 R 303 8x51 G.H5 Q 381 G.H5.26
Hydrophobic ICL3 L 222 - G.h4s6 P 345 G.h4s6.20
Ionic ICL1 K 65 12x48 G.HN D 44 G.HN.44
Polar ICL1 K 65 12x48 G.HN D 44 G.HN.44
Van-der-waals ICL1 K 65 12x48 G.HN D 44 G.HN.44
Polar ICL1 H 68 12x51 G.hns1 R 55 G.hns1.02
Polar ICL1 N 66 12x49 G.HN R 51 G.HN.51