Beta-arrestin-2 - MCH1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2024-10-31

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
MCH1 67.7
Beta-arrestin-2 80.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM3 V 146 3x55 s5s6 D 68 N.s5s6.04
Hydrophobic TM7 S 304 7x46 s5s6 L 74 N.s5s6.10
Van-der-waals TM7 S 304 7x46 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 A 218 5x48 s15s16 S 246 C.s15s16.04
Van-der-waals TM5 A 218 5x48 s15s16 S 246 C.s15s16.04
Polar N-term G 34 - S16 K 251 C.S16.04
Hydrophobic TM5 A 218 5x48 S15 I 242 C.S15.14
Van-der-waals TM5 A 218 5x48 S15 I 242 C.S15.14
Polar N-term I 36 - S16 Q 249 C.S16.02
Ionic TM3 R 141 3x50 s20c D 402 C.s20c.12
Hydrophobic TM3 R 141 3x50 s20c D 402 C.s20c.12
Polar TM5 L 219 5x49 s15s16 S 246 C.s15s16.04
Van-der-waals TM5 L 219 5x49 s15s16 S 246 C.s15s16.04
Hydrophobic N-term S 35 - S16 Q 249 C.S16.02
Van-der-waals N-term S 35 - S16 Q 249 C.S16.02
Hydrophobic TM7 Y 311 7x53 S6 D 79 N.S6.04
Van-der-waals TM7 Y 311 7x53 S6 D 79 N.S6.04
Polar H8 R 319 8x51 s5s6 S 75 N.s5s6.11
Hydrophobic H8 R 319 8x51 s5s6 S 75 N.s5s6.11
Van-der-waals H8 R 319 8x51 s5s6 S 75 N.s5s6.11
Hydrophobic TM5 F 217 5x47 S6 F 76 N.S6.01
Polar TM3 T 145 3x54 s5s6 E 67 N.s5s6.03
Van-der-waals TM3 T 145 3x54 s5s6 E 67 N.s5s6.03
Hydrophobic N-term T 33 - S16 P 253 C.S16.06
Van-der-waals N-term T 33 - S16 P 253 C.S16.06
Hydrophobic H8 V 326 8x58 s5s6 L 72 N.s5s6.08
Polar N-term T 33 - S16 K 251 C.S16.04
Hydrophobic N-term T 33 - S16 K 251 C.S16.04
Van-der-waals N-term T 33 - S16 K 251 C.S16.04
Van-der-waals TM5 A 218 5x48 s15s16 L 244 C.s15s16.02
Hydrophobic TM7 V 310 7x52 S6 D 79 N.S6.04
Hydrophobic H8 V 323 8x55 s5s6 L 74 N.s5s6.10
Van-der-waals H8 V 323 8x55 s5s6 L 74 N.s5s6.10
Polar TM5 A 218 5x48 S16 Y 250 C.S16.03
Hydrophobic TM5 A 218 5x48 S16 Y 250 C.S16.03
Van-der-waals TM5 A 218 5x48 S16 Y 250 C.S16.03
Hydrophobic H8 V 323 8x55 s5s6 L 72 N.s5s6.08
Van-der-waals H8 V 323 8x55 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 A 216 5x461 s15s16 S 246 C.s15s16.04
Hydrophobic TM7 I 297 7x38 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 F 221 5x51 S5 Y 64 N.S5.12
Van-der-waals TM5 F 221 5x51 S5 Y 64 N.S5.12
Polar TM5 F 221 5x51 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 F 221 5x51 s5s6 R 66 N.s5s6.02
Van-der-waals TM5 F 221 5x51 s5s6 R 66 N.s5s6.02
Polar H8 R 319 8x51 s5s6 L 74 N.s5s6.10
Hydrophobic H8 R 319 8x51 s5s6 L 74 N.s5s6.10
Van-der-waals H8 R 319 8x51 s5s6 L 74 N.s5s6.10
Polar TM5 A 218 5x48 S5 Y 64 N.S5.12
Hydrophobic TM5 A 218 5x48 S5 Y 64 N.S5.12
Van-der-waals TM5 A 218 5x48 S5 Y 64 N.S5.12
Polar TM3 T 145 3x54 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 F 217 5x47 s15s16 S 246 C.s15s16.04
Polar N-term T 33 - S16 C 252 C.S16.05
Hydrophobic N-term T 33 - S16 C 252 C.S16.05
Van-der-waals N-term T 33 - S16 C 252 C.S16.05
Hydrophobic TM3 H 147 3x56 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 H 147 3x56 s5s6 D 68 N.s5s6.04
Polar TM5 F 217 5x47 S5 Y 64 N.S5.12
Hydrophobic TM5 F 217 5x47 S5 Y 64 N.S5.12
Van-der-waals TM5 F 217 5x47 S5 Y 64 N.S5.12
Hydrophobic TM5 F 214 5x45 s5s6 L 74 N.s5s6.10
Polar TM5 F 221 5x51 S16 Y 250 C.S16.03
Van-der-waals TM5 F 221 5x51 S16 Y 250 C.S16.03
Polar TM5 I 224 5x54 s5s6 R 66 N.s5s6.02
Van-der-waals TM5 I 224 5x54 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 L 219 5x49 S16 A 248 C.S16.01
Hydrophobic TM7 G 300 7x41 s5s6 L 72 N.s5s6.08
Polar TM7 N 303 7x45 s15s16 F 245 C.s15s16.03
Hydrophobic TM7 N 303 7x45 s15s16 F 245 C.s15s16.03
Van-der-waals TM7 N 303 7x45 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 F 213 5x44 s5s6 L 69 N.s5s6.05
Van-der-waals TM5 F 213 5x44 s5s6 L 69 N.s5s6.05
Polar N-term I 36 - S16 K 251 C.S16.04
Hydrophobic N-term I 36 - S16 K 251 C.S16.04
Van-der-waals N-term I 36 - S16 K 251 C.S16.04
Hydrophobic TM5 F 217 5x47 s15s16 F 245 C.s15s16.03
Ionic TM3 M 137 3x46 s5s6 E 67 N.s5s6.03
Polar TM3 M 137 3x46 s5s6 E 67 N.s5s6.03
Van-der-waals TM3 M 137 3x46 s5s6 E 67 N.s5s6.03
Polar TM5 L 210 5x41 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 L 210 5x41 s5s6 V 71 N.s5s6.07
Van-der-waals TM5 L 210 5x41 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 F 214 5x45 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 H 147 3x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 H 147 3x56 s5s6 V 71 N.s5s6.07
Hydrophobic N-term P 30 - s17s18 K 285 C.s17s18.10
Hydrophobic TM7 F 309 7x51 S6 K 78 N.S6.03
Van-der-waals TM7 F 309 7x51 S6 K 78 N.S6.03
Hydrophobic TM5 F 214 5x45 S6 F 76 N.S6.01
Van-der-waals TM5 F 214 5x45 S6 F 76 N.S6.01
Hydrophobic N-term S 35 - S16 Y 250 C.S16.03
Polar H8 R 319 8x51 s5s6 G 73 N.s5s6.09
Van-der-waals H8 R 319 8x51 s5s6 G 73 N.s5s6.09
Ionic TM5 I 224 5x54 s5s6 D 68 N.s5s6.04
Polar TM5 I 224 5x54 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 I 224 5x54 s5s6 D 68 N.s5s6.04
Van-der-waals TM5 I 224 5x54 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 A 218 5x48 S16 A 248 C.S16.01
Van-der-waals TM5 A 218 5x48 S16 A 248 C.S16.01
Aromatic H8 R 319 8x51 S6 F 76 N.S6.01
Hydrophobic TM5 L 210 5x41 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 L 210 5x41 s5s6 L 72 N.s5s6.08
Hydrophobic TM7 N 307 7x49 s15s16 F 245 C.s15s16.03
Van-der-waals TM7 N 307 7x49 s15s16 F 245 C.s15s16.03