Arrestin-C - MCH1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2024-10-31

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
MCH1 67.0
Arrestin-C 81.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 17.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM7 N 303 7x45 s15s16 S 242 C.s15s16.04
Hydrophobic TM7 N 303 7x45 s15s16 S 242 C.s15s16.04
Van-der-waals TM7 N 303 7x45 s15s16 S 242 C.s15s16.04
Polar TM5 A 218 5x48 S16 Y 246 C.S16.03
Hydrophobic TM5 A 218 5x48 S16 Y 246 C.S16.03
Van-der-waals TM5 A 218 5x48 S16 Y 246 C.S16.03
Hydrophobic TM3 H 147 3x56 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 H 147 3x56 s5s6 V 66 N.s5s6.07
Polar TM7 N 303 7x45 s15s16 Y 241 C.s15s16.03
Hydrophobic TM7 N 303 7x45 s15s16 Y 241 C.s15s16.03
Van-der-waals TM7 N 303 7x45 s15s16 Y 241 C.s15s16.03
Hydrophobic TM7 P 308 7x50 S6 K 73 N.S6.03
Van-der-waals TM7 P 308 7x50 S6 K 73 N.S6.03
Hydrophobic TM5 A 218 5x48 S9 C 137 N.S9.01
Van-der-waals TM5 A 218 5x48 S9 C 137 N.S9.01
Hydrophobic TM5 A 218 5x48 S15 V 238 C.S15.14
Van-der-waals TM5 A 218 5x48 S15 V 238 C.S15.14
Polar TM5 L 219 5x49 S16 D 244 C.S16.01
Hydrophobic TM5 L 219 5x49 S16 D 244 C.S16.01
Van-der-waals TM5 L 219 5x49 S16 D 244 C.S16.01
Polar TM5 L 219 5x49 S16 Y 246 C.S16.03
Hydrophobic TM5 L 219 5x49 S16 Y 246 C.S16.03
Van-der-waals TM5 L 219 5x49 S16 Y 246 C.S16.03
Van-der-waals TM5 L 215 5x46 s15s16 Y 241 C.s15s16.03
Hydrophobic TM7 F 309 7x51 S6 D 74 N.S6.04
Van-der-waals TM7 F 309 7x51 S6 D 74 N.S6.04
Hydrophobic TM7 F 309 7x51 S6 K 73 N.S6.03
Van-der-waals TM7 F 309 7x51 S6 K 73 N.S6.03
Hydrophobic TM5 F 217 5x47 s15s16 S 242 C.s15s16.04
Van-der-waals TM5 F 217 5x47 s15s16 S 242 C.s15s16.04
Polar H8 R 319 8x51 S6 R 72 N.S6.02
Hydrophobic H8 V 326 8x58 s5s6 I 67 N.s5s6.08
Van-der-waals H8 V 326 8x58 s5s6 I 67 N.s5s6.08
Hydrophobic TM7 S 304 7x46 s5s6 L 69 N.s5s6.10
Van-der-waals TM7 S 304 7x46 s5s6 L 69 N.s5s6.10
Polar TM5 A 218 5x48 S16 D 244 C.S16.01
Hydrophobic TM5 A 218 5x48 S16 D 244 C.S16.01
Van-der-waals TM5 A 218 5x48 S16 D 244 C.S16.01
Hydrophobic TM5 L 210 5x41 s5s6 I 67 N.s5s6.08
Van-der-waals TM5 L 210 5x41 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 A 216 5x461 s15s16 S 242 C.s15s16.04
Hydrophobic TM7 V 313 7x55 S6 D 74 N.S6.04
Hydrophobic TM5 L 210 5x41 s5s6 V 66 N.s5s6.07
Van-der-waals TM5 L 210 5x41 s5s6 V 66 N.s5s6.07
Polar TM5 F 221 5x51 s17s18 R 282 C.s17s18.11
Hydrophobic TM5 F 221 5x51 s17s18 R 282 C.s17s18.11
Van-der-waals TM5 F 221 5x51 s17s18 R 282 C.s17s18.11
Ionic TM5 T 225 5x55 s8s9 E 131 N.s8s9.05
Polar TM5 T 225 5x55 s8s9 E 131 N.s8s9.05
Hydrophobic TM5 T 225 5x55 s8s9 E 131 N.s8s9.05
Van-der-waals TM5 T 225 5x55 s8s9 E 131 N.s8s9.05
Hydrophobic TM7 I 297 7x38 s5s6 I 67 N.s5s6.08
Van-der-waals TM7 I 297 7x38 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 F 214 5x45 S6 F 71 N.S6.01
Van-der-waals TM5 F 214 5x45 S6 F 71 N.S6.01
Hydrophobic TM7 S 304 7x46 s15s16 Y 241 C.s15s16.03
Polar TM5 F 217 5x47 S16 D 244 C.S16.01
Ionic TM7 N 303 7x45 s17s18 E 310 C.s17s18.39
Polar TM7 N 303 7x45 s17s18 E 310 C.s17s18.39
Hydrophobic TM1 N 40 1x32 s18s19 I 331 C.s18s19.05
Ionic TM7 L 314 7x56 s9s10 E 152 N.s9s10.07
Polar TM7 L 314 7x56 s9s10 E 152 N.s9s10.07
Hydrophobic TM7 L 314 7x56 s9s10 E 152 N.s9s10.07
Van-der-waals TM7 L 314 7x56 s9s10 E 152 N.s9s10.07
Hydrophobic TM7 V 313 7x55 S6 V 77 N.S6.07
Van-der-waals TM7 V 313 7x55 S6 V 77 N.S6.07
Hydrophobic H8 E 316 8x48 S6 D 74 N.S6.04
Ionic TM5 A 216 5x461 S16 D 244 C.S16.01
Hydrophobic TM5 A 218 5x48 S8 L 126 N.S8.03
Van-der-waals TM5 A 218 5x48 S8 L 126 N.S8.03
Ionic TM5 I 224 5x54 s5s6 D 63 N.s5s6.04
Polar TM5 I 224 5x54 s5s6 D 63 N.s5s6.04
Hydrophobic H8 V 323 8x55 s5s6 L 69 N.s5s6.10
Van-der-waals H8 V 323 8x55 s5s6 L 69 N.s5s6.10
Polar TM7 N 303 7x45 s15s16 V 239 C.s15s16.01
Van-der-waals TM7 N 303 7x45 s15s16 V 239 C.s15s16.01
Polar H8 R 319 8x51 s5s6 T 70 N.s5s6.11
Hydrophobic H8 R 319 8x51 s5s6 T 70 N.s5s6.11
Van-der-waals H8 R 319 8x51 s5s6 T 70 N.s5s6.11
Hydrophobic TM7 F 309 7x51 s17s18 L 311 C.s17s18.40
Polar TM7 N 307 7x49 S6 K 73 N.S6.03
Hydrophobic TM7 N 307 7x49 S6 K 73 N.S6.03
Van-der-waals TM7 N 307 7x49 S6 K 73 N.S6.03
Hydrophobic TM5 F 213 5x44 s5s6 L 64 N.s5s6.05
Van-der-waals TM5 F 213 5x44 s5s6 L 64 N.s5s6.05
Polar TM5 F 217 5x47 S5 Y 59 N.S5.12
Hydrophobic TM5 F 217 5x47 S5 Y 59 N.S5.12
Van-der-waals TM5 F 217 5x47 S5 Y 59 N.S5.12
Hydrophobic TM7 P 308 7x50 s17s18 L 311 C.s17s18.40
Polar TM7 N 307 7x49 s15s16 Y 241 C.s15s16.03
Hydrophobic TM7 N 307 7x49 s15s16 Y 241 C.s15s16.03
Van-der-waals TM7 N 307 7x49 s15s16 Y 241 C.s15s16.03
Hydrophobic TM7 G 300 7x41 s5s6 L 69 N.s5s6.10
Hydrophobic TM5 F 217 5x47 s15s16 Y 241 C.s15s16.03
Hydrophobic TM7 S 304 7x46 S6 F 71 N.S6.01
Van-der-waals TM7 S 304 7x46 S6 F 71 N.S6.01
Polar TM5 L 215 5x46 s15s16 S 242 C.s15s16.04
Hydrophobic TM5 L 215 5x46 s15s16 S 242 C.s15s16.04
Van-der-waals TM5 L 215 5x46 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 H 147 3x56 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 T 145 3x54 s5s6 D 63 N.s5s6.04
Hydrophobic TM5 F 221 5x51 S5 Y 59 N.S5.12
Van-der-waals TM5 F 221 5x51 S5 Y 59 N.S5.12
Hydrophobic TM7 F 309 7x51 S6 L 75 N.S6.05
Van-der-waals TM7 F 309 7x51 S6 L 75 N.S6.05
Polar H8 R 319 8x51 s5s6 G 68 N.s5s6.09
Van-der-waals H8 R 319 8x51 s5s6 G 68 N.s5s6.09
Hydrophobic H8 V 323 8x55 s5s6 I 67 N.s5s6.08
Polar TM5 A 218 5x48 S5 Y 59 N.S5.12
Hydrophobic TM5 A 218 5x48 S5 Y 59 N.S5.12
Van-der-waals TM5 A 218 5x48 S5 Y 59 N.S5.12