Gi2 - MCH2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 A 134 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM6 R 245 6x29 G.H5 L 349 G.H5.20
Hydrophobic TM2 P 68 2x39 G.H5 C 352 G.H5.23
Hydrophobic TM7 L 309 7x56 G.H5 G 353 G.H5.24
Hydrophobic ICL2 F 139 34x51 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 F 139 34x51 G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL3 C 236 - G.H5 F 335 G.H5.06
Hydrophobic ICL2 T 142 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 142 34x54 G.hns1 R 32 G.hns1.03
Polar C-term K 327 - G.H3 K 258 G.H3.16
Van-der-waals C-term K 327 - G.H3 K 258 G.H3.16
Van-der-waals ICL3 C 236 - G.S6 T 322 G.S6.03
Hydrophobic TM2 T 66 2x37 G.H5 D 351 G.H5.22
Hydrophobic TM6 L 256 6x40 G.H5 L 354 G.H5.25
Polar C-term N 331 - G.H3 K 258 G.H3.16
Hydrophobic C-term N 331 - G.H3 K 258 G.H3.16
Van-der-waals C-term N 331 - G.H3 K 258 G.H3.16
Hydrophobic TM3 L 135 3x54 G.H5 N 348 G.H5.19
Polar TM6 R 245 6x29 G.H5 D 342 G.H5.13
Hydrophobic TM3 L 135 3x54 G.H5 I 345 G.H5.16
Hydrophobic TM6 R 245 6x29 G.H5 K 346 G.H5.17
Van-der-waals TM6 R 245 6x29 G.H5 K 346 G.H5.17
Hydrophobic TM6 L 249 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 L 249 6x33 G.H5 L 349 G.H5.20
Hydrophobic TM5 Y 223 5x64 G.H5 I 345 G.H5.16
Hydrophobic TM6 V 241 6x25 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 V 241 6x25 G.h4s6 E 319 G.h4s6.12
Polar TM6 R 245 6x29 G.S6 Y 321 G.S6.02
Van-der-waals TM6 R 245 6x29 G.S6 Y 321 G.S6.02
Ionic H8 K 315 8x52 G.h3s5 D 262 G.h3s5.02
Polar H8 K 315 8x52 G.h3s5 D 262 G.h3s5.02
Van-der-waals H8 K 315 8x52 G.h3s5 D 262 G.h3s5.02
Hydrophobic TM3 L 135 3x54 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 138 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 138 34x50 G.H5 N 348 G.H5.19
Hydrophobic ICL2 F 139 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 F 139 34x51 G.H5 I 344 G.H5.15
Hydrophobic TM5 M 227 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 M 227 5x68 G.H5 I 345 G.H5.16
Hydrophobic ICL2 F 139 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 F 139 34x51 G.S3 L 195 G.S3.01
Polar TM4 T 146 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 T 146 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 T 146 4x38 G.HN E 28 G.HN.52
Polar TM5 N 231 5x72 G.H5 D 342 G.H5.13
Van-der-waals TM5 N 231 5x72 G.H5 D 342 G.H5.13
Polar ICL3 C 237 - G.S6 T 322 G.S6.03
Hydrophobic TM2 P 68 2x39 G.H5 D 351 G.H5.22
Van-der-waals TM2 P 68 2x39 G.H5 D 351 G.H5.22
Hydrophobic ICL3 C 237 - G.S6 Y 321 G.S6.02
Hydrophobic TM6 R 245 6x29 G.H5 F 355 G.H5.26
Hydrophobic ICL2 P 138 34x50 G.H5 I 344 G.H5.15
Polar TM3 R 131 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM6 L 249 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM3 R 131 3x50 G.H5 L 354 G.H5.25
Polar TM4 Y 148 4x40 G.HN R 24 G.HN.48
Aromatic TM4 Y 148 4x40 G.HN R 24 G.HN.48
Hydrophobic TM4 Y 148 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 Y 148 4x40 G.HN R 24 G.HN.48
Hydrophobic TM6 M 252 6x36 G.H5 F 355 G.H5.26
Polar TM3 A 134 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 134 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 N 348 G.H5.19
Polar H8 G 311 8x48 G.H5 F 355 G.H5.26
Ionic ICL2 R 143 34x55 G.s2s3 D 194 G.s2s3.02
Hydrophobic ICL3 A 234 - G.H5 F 335 G.H5.06
Ionic TM6 R 245 6x29 G.h4s6 E 319 G.h4s6.12
Polar TM6 R 245 6x29 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 R 245 6x29 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 R 245 6x29 G.h4s6 E 319 G.h4s6.12
Polar C-term E 328 - G.H3 K 258 G.H3.16
Hydrophobic C-term E 328 - G.H3 K 258 G.H3.16
Van-der-waals C-term E 328 - G.H3 K 258 G.H3.16
Hydrophobic TM6 M 252 6x36 G.H5 G 353 G.H5.24
Van-der-waals TM6 M 252 6x36 G.H5 G 353 G.H5.24
Polar TM6 N 238 6x22 G.H4 E 309 G.H4.16
Hydrophobic TM6 M 252 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 M 252 6x36 G.H5 L 354 G.H5.25
Hydrophobic ICL2 T 142 34x54 G.S3 L 195 G.S3.01
Polar H8 N 312 8x49 G.H5 K 350 G.H5.21
Hydrophobic H8 N 312 8x49 G.H5 K 350 G.H5.21
Polar TM6 K 248 6x32 G.H5 F 355 G.H5.26
Aromatic TM6 K 248 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM6 K 248 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 K 248 6x32 G.H5 F 355 G.H5.26
Hydrophobic C-term M 332 - G.H3 W 259 G.H3.17
Van-der-waals C-term M 332 - G.H3 W 259 G.H3.17
Polar ICL3 C 237 - G.S6 H 323 G.S6.04
Hydrophobic ICL3 C 237 - G.S6 H 323 G.S6.04
Polar H8 N 312 8x49 G.H5 D 351 G.H5.22
Hydrophobic ICL2 R 143 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 143 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals C-term M 332 - G.H3 K 258 G.H3.16
Polar H8 S 310 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 S 310 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 S 310 8x47 G.H5 G 353 G.H5.24
Hydrophobic TM3 L 135 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 L 135 3x54 G.H5 L 349 G.H5.20
Hydrophobic ICL2 F 139 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 F 139 34x51 G.H5 T 341 G.H5.12
Polar ICL3 C 236 - G.S6 H 323 G.S6.04
Hydrophobic ICL3 C 236 - G.S6 H 323 G.S6.04
Van-der-waals ICL3 C 236 - G.S6 H 323 G.S6.04