GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Ionic | ECL3 | R | 246 | - | G.H5 | D | 364 | G.H5.13 |
Polar | ECL3 | R | 246 | - | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | ECL3 | R | 246 | - | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | ECL3 | R | 246 | - | G.H5 | D | 364 | G.H5.13 |
Aromatic | TM6 | W | 241 | 6x60 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | W | 241 | 6x60 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | W | 241 | 6x60 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM7 | L | 249 | 7x29 | G.H5 | M | 375 | G.H5.24 |
Polar | N-term | E | 19 | - | G.S2 | E | 212 | G.S2.07 |
Hydrophobic | N-term | E | 19 | - | G.S2 | E | 212 | G.S2.07 |
Van-der-waals | N-term | E | 19 | - | G.S2 | E | 212 | G.S2.07 |
Hydrophobic | ECL2 | F | 163 | - | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | ECL2 | F | 163 | - | G.H5 | L | 376 | G.H5.25 |
Polar | ECL1 | S | 89 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ECL1 | S | 89 | - | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ECL1 | S | 89 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM7 | F | 250 | 7x30 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ECL2 | G | 167 | - | G.h4s6 | K | 340 | G.h4s6.19 |
Van-der-waals | ECL2 | G | 167 | - | G.h4s6 | K | 340 | G.h4s6.19 |
Polar | N-term | T | 21 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | N-term | T | 21 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | N-term | T | 21 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Polar | TM3 | K | 96 | 3x26 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM3 | K | 96 | 3x26 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | TM3 | K | 96 | 3x26 | G.H5 | Q | 373 | G.H5.22 |
Polar | TM5 | C | 173 | 5x36 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM5 | C | 173 | 5x36 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM5 | C | 173 | 5x36 | G.H5 | K | 372 | G.H5.21 |
Ionic | TM5 | D | 177 | 5x40 | G.H5 | K | 372 | G.H5.21 |
Polar | TM5 | D | 177 | 5x40 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM5 | D | 177 | 5x40 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM5 | D | 177 | 5x40 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM6 | F | 236 | 6x55 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM7 | F | 250 | 7x30 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM7 | F | 250 | 7x30 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | N-term | C | 23 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Polar | N-term | I | 15 | - | G.h1ha | Q | 74 | G.h1ha.02 |
Hydrophobic | N-term | I | 15 | - | G.h1ha | Q | 74 | G.h1ha.02 |
Van-der-waals | N-term | I | 15 | - | G.h1ha | Q | 74 | G.h1ha.02 |
Polar | ECL1 | H | 92 | - | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | ECL1 | H | 92 | - | G.H5 | Q | 373 | G.H5.22 |
Polar | N-term | N | 16 | - | G.S2 | D | 210 | G.S2.05 |
Van-der-waals | N-term | N | 16 | - | G.S2 | D | 210 | G.S2.05 |
Hydrophobic | N-term | T | 18 | - | G.S2 | E | 212 | G.S2.07 |
Van-der-waals | N-term | T | 18 | - | G.S2 | E | 212 | G.S2.07 |
Hydrophobic | TM6 | L | 240 | 6x59 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM6 | L | 240 | 6x59 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM2 | F | 87 | 2x65 | G.HN | S | 39 | G.HN.48 |
Polar | N-term | N | 16 | - | G.h1ha | Q | 74 | G.h1ha.02 |
Hydrophobic | N-term | N | 16 | - | G.h1ha | Q | 74 | G.h1ha.02 |
Van-der-waals | N-term | N | 16 | - | G.h1ha | Q | 74 | G.h1ha.02 |
Ionic | N-term | E | 20 | - | G.HN | R | 40 | G.HN.49 |
Polar | N-term | E | 20 | - | G.HN | R | 40 | G.HN.49 |
Van-der-waals | N-term | E | 20 | - | G.HN | R | 40 | G.HN.49 |
Hydrophobic | ECL3 | R | 246 | - | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | ECL3 | R | 246 | - | G.H5 | H | 368 | G.H5.17 |
Polar | N-term | Y | 24 | - | G.HN | R | 40 | G.HN.49 |
Polar | ECL2 | S | 166 | - | G.h3s5 | S | 282 | G.h3s5.01 |
Hydrophobic | ECL2 | S | 166 | - | G.h3s5 | S | 282 | G.h3s5.01 |
Van-der-waals | ECL2 | S | 166 | - | G.h3s5 | S | 282 | G.h3s5.01 |
Hydrophobic | ECL2 | F | 163 | - | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | ECL2 | F | 163 | - | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | ECL2 | G | 167 | - | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | ECL2 | G | 167 | - | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | TM7 | L | 255 | 7x35 | G.hns1 | R | 47 | G.hns1.03 |
Polar | ECL1 | H | 92 | - | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ECL1 | H | 92 | - | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | ECL1 | H | 92 | - | G.H5 | Q | 377 | G.H5.26 |
Polar | N-term | T | 21 | - | G.S2 | E | 212 | G.S2.07 |
Hydrophobic | N-term | T | 21 | - | G.S2 | E | 212 | G.S2.07 |
Van-der-waals | N-term | T | 21 | - | G.S2 | E | 212 | G.S2.07 |
Hydrophobic | TM6 | L | 240 | 6x59 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM6 | L | 240 | 6x59 | G.H5 | K | 372 | G.H5.21 |
Polar | TM2 | Y | 82 | 2x60 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM2 | Y | 82 | 2x60 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | Y | 82 | 2x60 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ECL3 | E | 247 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Polar | TM4 | C | 161 | 4x64 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM4 | C | 161 | 4x64 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM4 | C | 161 | 4x64 | G.H5 | K | 372 | G.H5.21 |
Polar | ECL2 | G | 162 | - | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | N-term | I | 15 | - | G.h1ha | D | 75 | G.h1ha.03 |
Van-der-waals | N-term | I | 15 | - | G.h1ha | D | 75 | G.h1ha.03 |
Polar | TM2 | S | 86 | 2x64 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM2 | S | 86 | 2x64 | G.HN | T | 43 | G.HN.52 |
Polar | TM2 | I | 88 | 2x66 | G.HN | K | 42 | G.HN.51 |
Hydrophobic | TM2 | I | 88 | 2x66 | G.HN | K | 42 | G.HN.51 |
Van-der-waals | TM2 | I | 88 | 2x66 | G.HN | K | 42 | G.HN.51 |
Hydrophobic | ECL2 | F | 163 | - | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | ECL2 | F | 163 | - | G.H5 | Q | 373 | G.H5.22 |
Polar | ECL2 | L | 164 | - | G.h3s5 | N | 283 | G.h3s5.02 |
Van-der-waals | ECL2 | L | 164 | - | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | N-term | I | 15 | - | G.H1 | H | 72 | G.H1.12 |
Van-der-waals | N-term | I | 15 | - | G.H1 | H | 72 | G.H1.12 |
Hydrophobic | ECL3 | R | 246 | - | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | ECL3 | R | 246 | - | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ECL3 | R | 246 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ECL1 | S | 89 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ECL1 | S | 89 | - | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM7 | C | 251 | 7x31 | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | TM7 | C | 251 | 7x31 | G.s2s3 | N | 215 | G.s2s3.02 |
Polar | ECL2 | S | 166 | - | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | ECL2 | S | 166 | - | G.h3s5 | N | 283 | G.h3s5.02 |
Van-der-waals | ECL2 | S | 166 | - | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | N-term | N | 16 | - | G.S2 | F | 211 | G.S2.06 |
Van-der-waals | N-term | N | 16 | - | G.S2 | F | 211 | G.S2.06 |
Polar | ECL1 | S | 89 | - | G.HN | S | 39 | G.HN.48 |
Van-der-waals | ECL1 | S | 89 | - | G.HN | S | 39 | G.HN.48 |
Polar | ECL3 | E | 247 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | ECL3 | E | 247 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ECL3 | E | 247 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | TM1 | T | 27 | 1x32 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM1 | T | 27 | 1x32 | G.hns1 | R | 47 | G.hns1.03 |
Polar | ECL2 | S | 166 | - | G.h4s6 | K | 340 | G.h4s6.19 |
Hydrophobic | ECL2 | S | 166 | - | G.h4s6 | K | 340 | G.h4s6.19 |
Van-der-waals | ECL2 | S | 166 | - | G.h4s6 | K | 340 | G.h4s6.19 |
Hydrophobic | TM6 | F | 236 | 6x55 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | F | 236 | 6x55 | G.H5 | M | 375 | G.H5.24 |
Ionic | TM4 | E | 157 | 4x60 | G.H5 | K | 372 | G.H5.21 |
Polar | TM4 | E | 157 | 4x60 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM4 | E | 157 | 4x60 | G.H5 | K | 372 | G.H5.21 |
Polar | TM2 | L | 85 | 2x63 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM2 | L | 85 | 2x63 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM2 | L | 85 | 2x63 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM7 | F | 250 | 7x30 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM7 | F | 250 | 7x30 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM2 | S | 86 | 2x64 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM2 | S | 86 | 2x64 | G.hns1 | K | 46 | G.hns1.02 |
Polar | N-term | P | 14 | - | G.h1ha | Q | 74 | G.h1ha.02 |
Hydrophobic | N-term | P | 14 | - | G.h1ha | Q | 74 | G.h1ha.02 |
Van-der-waals | N-term | P | 14 | - | G.h1ha | Q | 74 | G.h1ha.02 |
Polar | N-term | I | 15 | - | G.h1ha | G | 73 | G.h1ha.01 |
Hydrophobic | N-term | I | 15 | - | G.h1ha | G | 73 | G.h1ha.01 |
Van-der-waals | N-term | I | 15 | - | G.h1ha | G | 73 | G.h1ha.01 |
Polar | TM2 | Y | 82 | 2x60 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM2 | Y | 82 | 2x60 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | Y | 82 | 2x60 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM7 | F | 250 | 7x30 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM7 | F | 250 | 7x30 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM6 | Q | 235 | 6x54 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | Q | 235 | 6x54 | G.H5 | M | 375 | G.H5.24 |
Polar | ECL1 | I | 90 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ECL1 | I | 90 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ECL1 | I | 90 | - | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM2 | Y | 82 | 2x60 | G.hns1 | K | 46 | G.hns1.02 |
Aromatic | TM2 | Y | 82 | 2x60 | G.hns1 | K | 46 | G.hns1.02 |
Polar | ECL1 | S | 89 | - | G.HN | K | 42 | G.HN.51 |
Hydrophobic | ECL1 | S | 89 | - | G.HN | K | 42 | G.HN.51 |
Van-der-waals | ECL1 | S | 89 | - | G.HN | K | 42 | G.HN.51 |
Hydrophobic | TM6 | F | 236 | 6x55 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM6 | L | 240 | 6x59 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | L | 240 | 6x59 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | Y | 99 | 3x29 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM3 | Y | 99 | 3x29 | G.H5 | L | 376 | G.H5.25 |
Polar | N-term | C | 23 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | N-term | C | 23 | - | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM7 | H | 254 | 7x34 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM7 | H | 254 | 7x34 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM7 | H | 254 | 7x34 | G.H5 | M | 375 | G.H5.24 |
Polar | N-term | Y | 24 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | N-term | Y | 24 | - | G.HN | T | 43 | G.HN.52 |
Van-der-waals | N-term | Y | 24 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | N-term | T | 18 | - | G.HN | Y | 44 | G.HN.53 |
Van-der-waals | N-term | T | 18 | - | G.HN | Y | 44 | G.HN.53 |