G13 - MRGPRX1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM4 C 161 4x64 G.H5 K 372 G.H5.21
Hydrophobic TM4 C 161 4x64 G.H5 K 372 G.H5.21
Van-der-waals TM4 C 161 4x64 G.H5 K 372 G.H5.21
Polar ECL1 S 89 - G.HN S 39 G.HN.48
Van-der-waals ECL1 S 89 - G.HN S 39 G.HN.48
Hydrophobic TM7 L 249 7x29 G.H5 M 375 G.H5.24
Van-der-waals TM2 F 87 2x65 G.HN S 39 G.HN.48
Hydrophobic ECL3 R 246 - G.H5 L 367 G.H5.16
Van-der-waals ECL3 R 246 - G.H5 L 367 G.H5.16
Polar ECL1 S 89 - G.HN T 43 G.HN.52
Hydrophobic ECL1 S 89 - G.HN T 43 G.HN.52
Van-der-waals ECL1 S 89 - G.HN T 43 G.HN.52
Hydrophobic N-term I 15 - G.H1 H 72 G.H1.12
Van-der-waals N-term I 15 - G.H1 H 72 G.H1.12
Hydrophobic ECL3 E 247 - G.s2s3 K 214 G.s2s3.01
Polar N-term I 15 - G.h1ha G 73 G.h1ha.01
Hydrophobic N-term I 15 - G.h1ha G 73 G.h1ha.01
Van-der-waals N-term I 15 - G.h1ha G 73 G.h1ha.01
Polar TM7 C 251 7x31 G.s2s3 N 215 G.s2s3.02
Hydrophobic TM7 C 251 7x31 G.s2s3 N 215 G.s2s3.02
Polar TM2 Y 82 2x60 G.hns1 K 46 G.hns1.02
Aromatic TM2 Y 82 2x60 G.hns1 K 46 G.hns1.02
Ionic TM5 D 177 5x40 G.H5 K 372 G.H5.21
Polar TM5 D 177 5x40 G.H5 K 372 G.H5.21
Hydrophobic TM5 D 177 5x40 G.H5 K 372 G.H5.21
Van-der-waals TM5 D 177 5x40 G.H5 K 372 G.H5.21
Hydrophobic TM6 L 240 6x59 G.H5 M 375 G.H5.24
Van-der-waals TM6 L 240 6x59 G.H5 M 375 G.H5.24
Polar TM7 H 254 7x34 G.H5 M 375 G.H5.24
Hydrophobic TM7 H 254 7x34 G.H5 M 375 G.H5.24
Van-der-waals TM7 H 254 7x34 G.H5 M 375 G.H5.24
Hydrophobic TM6 L 240 6x59 G.H5 K 372 G.H5.21
Van-der-waals TM6 L 240 6x59 G.H5 K 372 G.H5.21
Polar ECL2 G 162 - G.H5 Q 373 G.H5.22
Van-der-waals TM7 L 255 7x35 G.hns1 R 47 G.hns1.03
Hydrophobic TM1 T 27 1x32 G.hns1 R 47 G.hns1.03
Van-der-waals TM1 T 27 1x32 G.hns1 R 47 G.hns1.03
Hydrophobic TM7 F 250 7x30 G.H5 L 374 G.H5.23
Van-der-waals TM7 F 250 7x30 G.H5 L 374 G.H5.23
Polar N-term C 23 - G.hns1 R 47 G.hns1.03
Van-der-waals N-term C 23 - G.hns1 R 47 G.hns1.03
Ionic ECL3 R 246 - G.H5 D 364 G.H5.13
Polar ECL3 R 246 - G.H5 D 364 G.H5.13
Hydrophobic ECL3 R 246 - G.H5 D 364 G.H5.13
Van-der-waals ECL3 R 246 - G.H5 D 364 G.H5.13
Polar TM2 I 88 2x66 G.HN K 42 G.HN.51
Hydrophobic TM2 I 88 2x66 G.HN K 42 G.HN.51
Van-der-waals TM2 I 88 2x66 G.HN K 42 G.HN.51
Hydrophobic ECL3 R 246 - G.H5 L 371 G.H5.20
Ionic N-term E 20 - G.HN R 40 G.HN.49
Polar N-term E 20 - G.HN R 40 G.HN.49
Van-der-waals N-term E 20 - G.HN R 40 G.HN.49
Polar ECL1 S 89 - G.HN K 42 G.HN.51
Hydrophobic ECL1 S 89 - G.HN K 42 G.HN.51
Van-der-waals ECL1 S 89 - G.HN K 42 G.HN.51
Polar N-term T 21 - G.s2s3 N 215 G.s2s3.02
Hydrophobic N-term T 21 - G.s2s3 N 215 G.s2s3.02
Van-der-waals N-term T 21 - G.s2s3 N 215 G.s2s3.02
Polar N-term Y 24 - G.HN R 40 G.HN.49
Ionic TM4 E 157 4x60 G.H5 K 372 G.H5.21
Polar TM4 E 157 4x60 G.H5 K 372 G.H5.21
Van-der-waals TM4 E 157 4x60 G.H5 K 372 G.H5.21
Hydrophobic TM7 F 250 7x30 G.hns1 R 47 G.hns1.03
Van-der-waals TM7 F 250 7x30 G.hns1 R 47 G.hns1.03
Hydrophobic ECL1 S 89 - G.hns1 K 46 G.hns1.02
Van-der-waals ECL1 S 89 - G.hns1 K 46 G.hns1.02
Polar ECL1 H 92 - G.H5 Q 373 G.H5.22
Hydrophobic ECL1 H 92 - G.H5 Q 373 G.H5.22
Polar N-term E 19 - G.S2 E 212 G.S2.07
Hydrophobic N-term E 19 - G.S2 E 212 G.S2.07
Van-der-waals N-term E 19 - G.S2 E 212 G.S2.07
Polar N-term N 16 - G.S2 D 210 G.S2.05
Van-der-waals N-term N 16 - G.S2 D 210 G.S2.05
Polar TM2 Y 82 2x60 G.H5 L 376 G.H5.25
Hydrophobic TM2 Y 82 2x60 G.H5 L 376 G.H5.25
Van-der-waals TM2 Y 82 2x60 G.H5 L 376 G.H5.25
Hydrophobic N-term N 16 - G.S2 F 211 G.S2.06
Van-der-waals N-term N 16 - G.S2 F 211 G.S2.06
Hydrophobic TM6 L 240 6x59 G.H5 L 371 G.H5.20
Van-der-waals TM6 L 240 6x59 G.H5 L 371 G.H5.20
Hydrophobic TM6 Q 235 6x54 G.H5 M 375 G.H5.24
Van-der-waals TM6 Q 235 6x54 G.H5 M 375 G.H5.24
Hydrophobic ECL2 G 167 - G.h4s6 K 340 G.h4s6.19
Van-der-waals ECL2 G 167 - G.h4s6 K 340 G.h4s6.19
Hydrophobic TM7 F 250 7x30 G.H5 M 375 G.H5.24
Van-der-waals TM7 F 250 7x30 G.H5 M 375 G.H5.24
Hydrophobic TM6 F 236 6x55 G.H5 K 372 G.H5.21
Polar TM2 L 85 2x63 G.hns1 K 46 G.hns1.02
Hydrophobic TM2 L 85 2x63 G.hns1 K 46 G.hns1.02
Van-der-waals TM2 L 85 2x63 G.hns1 K 46 G.hns1.02
Polar ECL3 E 247 - G.s2s3 N 215 G.s2s3.02
Hydrophobic ECL3 E 247 - G.s2s3 N 215 G.s2s3.02
Van-der-waals ECL3 E 247 - G.s2s3 N 215 G.s2s3.02
Hydrophobic TM3 Y 99 3x29 G.H5 L 376 G.H5.25
Van-der-waals TM3 Y 99 3x29 G.H5 L 376 G.H5.25
Polar ECL1 I 90 - G.hns1 K 46 G.hns1.02
Hydrophobic ECL1 I 90 - G.hns1 K 46 G.hns1.02
Van-der-waals ECL1 I 90 - G.hns1 K 46 G.hns1.02
Polar N-term N 16 - G.h1ha Q 74 G.h1ha.02
Hydrophobic N-term N 16 - G.h1ha Q 74 G.h1ha.02
Van-der-waals N-term N 16 - G.h1ha Q 74 G.h1ha.02
Hydrophobic ECL2 F 163 - G.H5 Q 373 G.H5.22
Van-der-waals ECL2 F 163 - G.H5 Q 373 G.H5.22
Hydrophobic TM2 S 86 2x64 G.hns1 K 46 G.hns1.02
Van-der-waals TM2 S 86 2x64 G.hns1 K 46 G.hns1.02
Polar ECL2 L 164 - G.h3s5 N 283 G.h3s5.02
Van-der-waals ECL2 L 164 - G.h3s5 N 283 G.h3s5.02
Hydrophobic TM6 F 236 6x55 G.H5 M 375 G.H5.24
Van-der-waals TM6 F 236 6x55 G.H5 M 375 G.H5.24
Polar TM3 K 96 3x26 G.H5 Q 373 G.H5.22
Hydrophobic TM3 K 96 3x26 G.H5 Q 373 G.H5.22
Van-der-waals TM3 K 96 3x26 G.H5 Q 373 G.H5.22
Polar ECL2 S 166 - G.h3s5 N 283 G.h3s5.02
Hydrophobic ECL2 S 166 - G.h3s5 N 283 G.h3s5.02
Van-der-waals ECL2 S 166 - G.h3s5 N 283 G.h3s5.02
Hydrophobic ECL2 F 163 - G.H5 L 376 G.H5.25
Van-der-waals ECL2 F 163 - G.H5 L 376 G.H5.25
Polar TM2 S 86 2x64 G.HN T 43 G.HN.52
Hydrophobic TM2 S 86 2x64 G.HN T 43 G.HN.52
Polar TM2 Y 82 2x60 G.H5 Q 377 G.H5.26
Hydrophobic TM2 Y 82 2x60 G.H5 Q 377 G.H5.26
Van-der-waals TM2 Y 82 2x60 G.H5 Q 377 G.H5.26
Hydrophobic TM7 F 250 7x30 G.H5 L 371 G.H5.20
Hydrophobic N-term I 15 - G.h1ha D 75 G.h1ha.03
Van-der-waals N-term I 15 - G.h1ha D 75 G.h1ha.03
Hydrophobic N-term T 18 - G.S2 E 212 G.S2.07
Van-der-waals N-term T 18 - G.S2 E 212 G.S2.07
Polar ECL2 S 166 - G.h3s5 S 282 G.h3s5.01
Hydrophobic ECL2 S 166 - G.h3s5 S 282 G.h3s5.01
Van-der-waals ECL2 S 166 - G.h3s5 S 282 G.h3s5.01
Hydrophobic TM6 F 236 6x55 G.H5 L 376 G.H5.25
Hydrophobic ECL2 G 167 - G.h4s6 Q 339 G.h4s6.13
Van-der-waals ECL2 G 167 - G.h4s6 Q 339 G.h4s6.13
Hydrophobic N-term C 23 - G.s2s3 N 215 G.s2s3.02
Hydrophobic ECL3 R 246 - G.H5 H 368 G.H5.17
Van-der-waals ECL3 R 246 - G.H5 H 368 G.H5.17
Polar N-term Y 24 - G.HN T 43 G.HN.52
Hydrophobic N-term Y 24 - G.HN T 43 G.HN.52
Van-der-waals N-term Y 24 - G.HN T 43 G.HN.52
Polar N-term P 14 - G.h1ha Q 74 G.h1ha.02
Hydrophobic N-term P 14 - G.h1ha Q 74 G.h1ha.02
Van-der-waals N-term P 14 - G.h1ha Q 74 G.h1ha.02
Hydrophobic ECL2 F 163 - G.H5 K 372 G.H5.21
Van-der-waals ECL2 F 163 - G.H5 K 372 G.H5.21
Polar TM5 C 173 5x36 G.H5 K 372 G.H5.21
Hydrophobic TM5 C 173 5x36 G.H5 K 372 G.H5.21
Van-der-waals TM5 C 173 5x36 G.H5 K 372 G.H5.21
Aromatic TM6 W 241 6x60 G.H5 H 368 G.H5.17
Hydrophobic TM6 W 241 6x60 G.H5 H 368 G.H5.17
Van-der-waals TM6 W 241 6x60 G.H5 H 368 G.H5.17
Polar ECL1 H 92 - G.H5 Q 377 G.H5.26
Hydrophobic ECL1 H 92 - G.H5 Q 377 G.H5.26
Van-der-waals ECL1 H 92 - G.H5 Q 377 G.H5.26
Polar N-term I 15 - G.h1ha Q 74 G.h1ha.02
Hydrophobic N-term I 15 - G.h1ha Q 74 G.h1ha.02
Van-der-waals N-term I 15 - G.h1ha Q 74 G.h1ha.02
Hydrophobic N-term T 18 - G.HN Y 44 G.HN.53
Van-der-waals N-term T 18 - G.HN Y 44 G.HN.53
Polar N-term T 21 - G.S2 E 212 G.S2.07
Hydrophobic N-term T 21 - G.S2 E 212 G.S2.07
Van-der-waals N-term T 21 - G.S2 E 212 G.S2.07
Polar ECL2 S 166 - G.h4s6 K 340 G.h4s6.19
Hydrophobic ECL2 S 166 - G.h4s6 K 340 G.h4s6.19
Van-der-waals ECL2 S 166 - G.h4s6 K 340 G.h4s6.19