GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | I | 128 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM2 | N | 59 | 2x37 | G.H5 | L | 380 | G.H5.25 |
Polar | TM7 | G | 276 | 7x57 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM7 | G | 276 | 7x57 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM7 | G | 276 | 7x57 | G.H5 | M | 379 | G.H5.24 |
Polar | ICL2 | C | 132 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | C | 132 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | C | 132 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | P | 127 | 34x50 | G.H5 | L | 371 | G.H5.16 |
Polar | TM3 | R | 120 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 120 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 120 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | C-term | W | 307 | - | G.h4s6 | R | 339 | G.h4s6.08 |
Hydrophobic | TM2 | I | 65 | 2x43 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM2 | I | 65 | 2x43 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL2 | R | 133 | 34x56 | G.s2s3 | K | 220 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 133 | 34x56 | G.s2s3 | K | 220 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 133 | 34x56 | G.s2s3 | K | 220 | G.s2s3.02 |
Hydrophobic | C-term | L | 291 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | L | 291 | - | G.H3 | K | 284 | G.H3.16 |
Ionic | ICL2 | H | 131 | 34x54 | G.H5 | E | 373 | G.H5.18 |
Polar | ICL2 | H | 131 | 34x54 | G.H5 | E | 373 | G.H5.18 |
Van-der-waals | ICL2 | H | 131 | 34x54 | G.H5 | E | 373 | G.H5.18 |
Polar | C-term | L | 313 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | C-term | L | 313 | - | G.S6 | H | 348 | G.S6.03 |
Van-der-waals | C-term | L | 313 | - | G.S6 | H | 348 | G.S6.03 |
Polar | TM2 | N | 59 | 2x37 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM2 | N | 59 | 2x37 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | TM2 | N | 59 | 2x37 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | C-term | T | 312 | - | G.S6 | L | 346 | G.S6.01 |
Hydrophobic | C-term | L | 313 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | C-term | L | 313 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | C-term | V | 290 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | V | 290 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | C-term | L | 295 | - | G.H2 | F | 239 | G.H2.08 |
Hydrophobic | ICL2 | I | 128 | 34x51 | G.S1 | V | 58 | G.S1.02 |
Ionic | ICL3 | R | 207 | - | G.H5 | D | 368 | G.H5.13 |
Polar | ICL3 | R | 207 | - | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | ICL3 | R | 207 | - | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | ICL3 | R | 207 | - | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM6 | L | 214 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | L | 214 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM7 | Y | 272 | 7x53 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | Y | 272 | 7x53 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | I | 128 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | I | 128 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | ICL2 | P | 127 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | P | 127 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | C-term | W | 307 | - | G.h4s6 | N | 341 | G.h4s6.10 |
Polar | C-term | L | 308 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Van-der-waals | C-term | L | 308 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Polar | C-term | L | 315 | - | G.S6 | H | 348 | G.S6.03 |
Van-der-waals | C-term | L | 315 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | C-term | L | 315 | - | G.S6 | F | 347 | G.S6.02 |
Van-der-waals | C-term | L | 315 | - | G.S6 | F | 347 | G.S6.02 |
Hydrophobic | C-term | W | 307 | - | G.h4s6 | R | 340 | G.h4s6.09 |
Van-der-waals | C-term | W | 307 | - | G.h4s6 | R | 340 | G.h4s6.09 |
Hydrophobic | ICL3 | M | 209 | - | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | ICL3 | M | 209 | - | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | TM7 | G | 276 | 7x57 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | G | 276 | 7x57 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | T | 312 | - | G.H4 | V | 332 | G.H4.12 |
Van-der-waals | C-term | T | 312 | - | G.H4 | V | 332 | G.H4.12 |
Hydrophobic | TM3 | S | 123 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | S | 123 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Polar | ICL3 | R | 207 | - | G.H5 | H | 364 | G.H5.09 |
Hydrophobic | ICL3 | R | 207 | - | G.H5 | H | 364 | G.H5.09 |
Hydrophobic | C-term | L | 315 | - | G.H5 | F | 361 | G.H5.06 |
Van-der-waals | C-term | L | 315 | - | G.H5 | F | 361 | G.H5.06 |
Hydrophobic | ICL2 | I | 128 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | I | 128 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | C-term | L | 291 | - | G.H3 | N | 283 | G.H3.15 |
Polar | C-term | K | 288 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | K | 288 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | TM7 | F | 273 | 7x54 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | F | 273 | 7x54 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL2 | R | 133 | 34x56 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | R | 133 | 34x56 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | P | 127 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | ICL2 | P | 127 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM3 | I | 124 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM3 | I | 124 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | ICL2 | C | 132 | 34x55 | G.S1 | V | 58 | G.S1.02 |
Polar | C-term | L | 313 | - | G.S6 | L | 346 | G.S6.01 |
Van-der-waals | C-term | L | 313 | - | G.S6 | L | 346 | G.S6.01 |
Hydrophobic | C-term | L | 287 | - | G.h3s5 | F | 287 | G.h3s5.01 |
Van-der-waals | C-term | L | 287 | - | G.h3s5 | F | 287 | G.h3s5.01 |
Hydrophobic | TM7 | G | 276 | 7x57 | G.H5 | Q | 381 | G.H5.26 |
Polar | C-term | Q | 280 | - | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | C-term | Q | 280 | - | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | C-term | Q | 280 | - | G.H5 | Q | 381 | G.H5.26 |
Polar | C-term | N | 286 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | N | 286 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | TM2 | V | 61 | 2x39 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | C-term | T | 312 | - | G.S6 | H | 348 | G.S6.03 |
Van-der-waals | C-term | T | 312 | - | G.S6 | H | 348 | G.S6.03 |
Polar | TM3 | S | 123 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | S | 123 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | S | 123 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL3 | R | 207 | - | G.S6 | F | 347 | G.S6.02 |
Van-der-waals | ICL3 | R | 207 | - | G.S6 | F | 347 | G.S6.02 |
Polar | ICL2 | P | 127 | 34x50 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | P | 127 | 34x50 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL2 | H | 131 | 34x54 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | H | 131 | 34x54 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM3 | I | 124 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | I | 124 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Polar | C-term | Q | 310 | - | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | C-term | Q | 310 | - | G.h4s6 | S | 343 | G.h4s6.12 |
Polar | TM4 | Y | 137 | 4x40 | G.HN | R | 52 | G.HN.52 |
Aromatic | TM4 | Y | 137 | 4x40 | G.HN | R | 52 | G.HN.52 |
Hydrophobic | TM4 | Y | 137 | 4x40 | G.HN | R | 52 | G.HN.52 |
Van-der-waals | TM4 | Y | 137 | 4x40 | G.HN | R | 52 | G.HN.52 |
Hydrophobic | TM6 | L | 211 | 6x30 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | I | 128 | 34x51 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | C-term | L | 315 | - | G.H5 | A | 365 | G.H5.10 |
Hydrophobic | TM6 | R | 213 | 6x32 | G.H5 | M | 379 | G.H5.24 |
Polar | ICL2 | C | 132 | 34x55 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | C | 132 | 34x55 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | C | 132 | 34x55 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM6 | L | 214 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM6 | L | 214 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM4 | R | 136 | 4x39 | G.HN | R | 52 | G.HN.52 |
Van-der-waals | TM4 | R | 136 | 4x39 | G.HN | R | 52 | G.HN.52 |
Polar | ICL2 | H | 131 | 34x54 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM6 | T | 217 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | T | 217 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | C-term | T | 312 | - | G.H4 | D | 336 | G.H4.16 |
Van-der-waals | C-term | T | 312 | - | G.H4 | D | 336 | G.H4.16 |
Hydrophobic | C-term | L | 313 | - | G.S6 | F | 347 | G.S6.02 |
Polar | TM7 | S | 277 | 7x58 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | Y | 130 | 34x53 | G.H5 | N | 374 | G.H5.19 |
Ionic | C-term | E | 314 | - | G.S6 | H | 348 | G.S6.03 |
Polar | C-term | E | 314 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | C-term | E | 314 | - | G.S6 | H | 348 | G.S6.03 |
Van-der-waals | C-term | E | 314 | - | G.S6 | H | 348 | G.S6.03 |
Polar | C-term | L | 315 | - | G.S6 | H | 349 | G.S6.04 |
Hydrophobic | TM2 | S | 62 | 2x40 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL3 | M | 209 | - | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | ICL3 | M | 209 | - | G.H5 | L | 375 | G.H5.20 |
Polar | C-term | W | 307 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Hydrophobic | C-term | W | 307 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Van-der-waals | C-term | W | 307 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Polar | C-term | L | 287 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | C-term | L | 287 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | L | 287 | - | G.H3 | K | 284 | G.H3.16 |
Polar | C-term | Q | 310 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Hydrophobic | C-term | Q | 310 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Van-der-waals | C-term | Q | 310 | - | G.h4s6 | R | 342 | G.h4s6.11 |