Gs -
MC1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 85.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL3 | R | 227 | - | G.hgh4 | P | 321 | G.hgh4.11 |
Aromatic | TM3 | R | 142 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | R | 142 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | R | 142 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | H | 153 | 34x54 | G.hns1 | A | 39 | G.hns1.03 |
Polar | ICL2 | H | 153 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | H | 153 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | H | 153 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM5 | A | 218 | 5x69 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM5 | A | 214 | 5x65 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM5 | A | 214 | 5x65 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM4 | L | 158 | 4x39 | G.HN | Q | 31 | G.HN.48 |
Van-der-waals | TM4 | L | 158 | 4x39 | G.HN | Q | 31 | G.HN.48 |
Hydrophobic | ICL2 | A | 149 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Polar | TM5 | H | 217 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | H | 217 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | H | 217 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | I | 221 | 5x72 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | I | 221 | 5x72 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | I | 221 | 5x72 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | TM6 | F | 235 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | F | 235 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | L | 150 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | L | 150 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | TM4 | T | 157 | 4x38 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | TM4 | T | 157 | 4x38 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM5 | M | 210 | 5x61 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | L | 150 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | L | 150 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Polar | ICL3 | Q | 228 | - | G.H4 | R | 347 | G.H4.17 |
Ionic | TM5 | H | 217 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Polar | TM5 | H | 217 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM5 | H | 217 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | H | 217 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | ICL2 | L | 150 | 34x51 | G.H5 | C | 379 | G.H5.11 |
Polar | TM3 | S | 145 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | S | 145 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | S | 145 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM5 | I | 221 | 5x72 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | R | 151 | 34x52 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | R | 151 | 34x52 | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | TM5 | H | 217 | 5x68 | G.H5 | L | 394 | G.H5.26 |
Ionic | TM6 | K | 238 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | K | 238 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | T | 242 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL2 | H | 153 | 34x54 | G.HN | Q | 35 | G.HN.52 |
Ionic | ICL1 | R | 67 | 12x48 | G.HN | E | 27 | G.HN.44 |
Polar | ICL1 | R | 67 | 12x48 | G.HN | E | 27 | G.HN.44 |
Van-der-waals | ICL1 | R | 67 | 12x48 | G.HN | E | 27 | G.HN.44 |
Polar | TM3 | S | 145 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | S | 145 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL3 | R | 227 | - | G.H4 | R | 342 | G.H4.12 |
Van-der-waals | ICL3 | R | 227 | - | G.H4 | R | 342 | G.H4.12 |
Hydrophobic | ICL2 | L | 150 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM5 | A | 214 | 5x65 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM5 | A | 214 | 5x65 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | I | 146 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Ionic | ICL3 | R | 227 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Polar | ICL3 | R | 227 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL3 | R | 227 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | R | 227 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Polar | TM6 | G | 239 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | G | 239 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | G | 239 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Polar | TM6 | G | 239 | 6x33 | G.H5 | E | 392 | G.H5.24 |
Ionic | TM7 | H | 301 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Polar | TM7 | H | 301 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM7 | H | 301 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM7 | H | 301 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM5 | H | 217 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | H | 217 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Polar | TM5 | R | 213 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | R | 213 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | R | 213 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | A | 214 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | A | 149 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Polar | ICL3 | Q | 228 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | ICL3 | Q | 228 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Van-der-waals | ICL3 | Q | 228 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | TM5 | H | 217 | 5x68 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM5 | H | 217 | 5x68 | G.H5 | L | 388 | G.H5.20 |
Polar | TM3 | I | 146 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | I | 146 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Polar | TM6 | K | 238 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | K | 238 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | K | 238 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Polar | ICL2 | L | 150 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | L | 150 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | L | 150 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Polar | TM6 | T | 242 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | T | 242 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | T | 242 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM2 | M | 73 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Ionic | ICL3 | R | 227 | - | G.H4 | D | 343 | G.H4.13 |
Hydrophobic | ICL2 | A | 149 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | A | 149 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | ICL2 | L | 150 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | L | 150 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | H | 387 | G.H5.19 |