Gt2 - motilin receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 P 143 34x50 G.H5 N 347 G.H5.19
Ionic TM5 R 279 5x70 G.H5 D 341 G.H5.13
Polar TM5 R 279 5x70 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 279 5x70 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 279 5x70 G.H5 D 341 G.H5.13
Hydrophobic H8 S 359 8x47 G.H5 G 352 G.H5.24
Ionic TM5 R 279 5x70 G.H5 D 337 G.H5.09
Polar TM5 R 279 5x70 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 279 5x70 G.H5 D 337 G.H5.09
Van-der-waals TM5 R 279 5x70 G.H5 D 337 G.H5.09
Ionic C-term E 403 - G.S2 K 188 G.S2.05
Polar C-term E 403 - G.S2 K 188 G.S2.05
Van-der-waals C-term E 403 - G.S2 K 188 G.S2.05
Hydrophobic ICL3 P 284 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL2 L 144 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 144 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM5 L 281 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM6 V 299 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 299 6x36 G.H5 L 353 G.H5.25
Polar TM2 T 73 2x39 G.H5 D 350 G.H5.22
Polar TM6 R 289 6x26 G.S6 Y 320 G.S6.02
Polar ICL3 A 285 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 A 285 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL2 L 144 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM3 A 139 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 144 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 144 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 R 147 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 R 147 34x54 G.S3 L 194 G.S3.01
Ionic TM6 R 289 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 T 296 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 296 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 296 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 281 5x72 G.S6 I 319 G.S6.01
Van-der-waals TM5 L 281 5x72 G.S6 I 319 G.S6.01
Polar TM3 A 139 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 139 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 139 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 143 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 T 296 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM7 I 358 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 I 358 7x56 G.H5 G 352 G.H5.24
Hydrophobic ICL2 R 147 34x54 G.H5 I 343 G.H5.15
Ionic ICL1 R 67 12x48 G.HN E 20 G.HN.44
Polar ICL1 R 67 12x48 G.HN E 20 G.HN.44
Hydrophobic ICL1 R 67 12x48 G.HN E 20 G.HN.44
Van-der-waals ICL1 R 67 12x48 G.HN E 20 G.HN.44
Polar TM2 T 73 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 73 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 300 6x37 G.H5 L 353 G.H5.25
Ionic ICL2 R 147 34x54 G.H5 E 346 G.H5.18
Polar ICL2 R 147 34x54 G.H5 E 346 G.H5.18
Van-der-waals ICL2 R 147 34x54 G.H5 E 346 G.H5.18
Polar TM3 R 136 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 136 3x50 G.H5 C 351 G.H5.23
Ionic ICL1 R 70 12x51 G.HN E 20 G.HN.44
Polar ICL1 R 70 12x51 G.HN E 20 G.HN.44
Van-der-waals ICL1 R 70 12x51 G.HN E 20 G.HN.44
Hydrophobic TM3 R 136 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL3 A 285 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM7 I 358 7x56 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 143 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 143 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM3 I 140 3x54 G.H5 L 353 G.H5.25
Polar ICL2 R 147 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 147 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 147 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 P 143 34x50 G.H5 I 344 G.H5.16
Polar ICL2 V 148 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 V 148 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 V 148 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 V 148 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 V 148 34x55 G.S3 L 194 G.S3.01
Hydrophobic TM3 I 140 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 140 3x54 G.H5 L 348 G.H5.20
Polar TM4 R 152 4x39 G.HN Q 24 G.HN.48
Hydrophobic TM4 R 152 4x39 G.HN Q 24 G.HN.48
Van-der-waals TM4 R 152 4x39 G.HN Q 24 G.HN.48
Hydrophobic TM5 L 281 5x72 G.h4s6 E 318 G.h4s6.12
Ionic TM6 R 289 6x26 G.H5 D 341 G.H5.13
Polar TM6 R 289 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 289 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 289 6x26 G.H5 D 341 G.H5.13
Hydrophobic ICL2 L 144 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 144 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM4 T 151 4x38 G.HN D 28 G.HN.52
Polar ICL2 R 147 34x54 G.S1 T 33 G.S1.01
Hydrophobic ICL2 L 144 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM5 L 274 5x65 G.H5 L 348 G.H5.20