G12 - NK2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 N 69 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 N 69 2x40 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 139 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 139 - G.S3 I 221 G.S3.01
Hydrophobic ICL2 F 139 - G.S3 F 223 G.S3.03
Polar C-term Y 386 - G.H2 R 232 G.H2.01
Hydrophobic C-term Y 386 - G.H2 R 232 G.H2.01
Van-der-waals C-term Y 386 - G.H2 R 232 G.H2.01
Hydrophobic C-term L 389 - G.H2 S 233 G.H2.02
Van-der-waals C-term L 389 - G.H2 S 233 G.H2.02
Polar C-term V 396 - H.HA K 114 H.HA.28
Hydrophobic C-term V 396 - H.HA K 114 H.HA.28
Van-der-waals C-term V 396 - H.HA K 114 H.HA.28
Polar H8 N 311 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 N 311 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 311 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 141 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 P 141 - G.hns1 R 56 G.hns1.03
Polar TM5 R 227 5x68 G.H5 K 367 G.H5.12
Hydrophobic TM5 R 227 5x68 G.H5 K 367 G.H5.12
Van-der-waals TM5 R 227 5x68 G.H5 K 367 G.H5.12
Hydrophobic TM5 P 230 5x71 G.S6 F 347 G.S6.02
Hydrophobic TM6 A 237 6x22 G.h4s6 R 342 G.h4s6.11
Van-der-waals TM6 A 237 6x22 G.h4s6 R 342 G.h4s6.11
Aromatic ICL2 F 139 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 139 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 139 - G.H5 F 363 G.H5.08
Hydrophobic TM5 R 227 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 227 5x68 G.H5 L 371 G.H5.16
Ionic C-term E 397 - G.s4h3 R 265 G.s4h3.12
Polar C-term E 397 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term E 397 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term E 397 - G.s4h3 R 265 G.s4h3.12
Hydrophobic ICL2 R 142 - G.H5 I 378 G.H5.23
Van-der-waals ICL2 R 142 - G.H5 I 378 G.H5.23
Polar C-term V 396 - H.HA D 110 H.HA.24
Hydrophobic C-term V 396 - H.HA D 110 H.HA.24
Van-der-waals C-term V 396 - H.HA D 110 H.HA.24
Hydrophobic C-term I 398 - H.HA K 114 H.HA.28
Van-der-waals C-term I 398 - H.HA K 114 H.HA.28
Hydrophobic C-term V 396 - H.HA V 107 H.HA.21
Van-der-waals C-term V 396 - H.HA V 107 H.HA.21
Polar C-term H 395 - G.s4h3 R 265 G.s4h3.12
Polar TM5 H 232 5x73 G.S6 F 347 G.S6.02
Aromatic TM5 H 232 5x73 G.S6 F 347 G.S6.02
Hydrophobic TM5 H 232 5x73 G.S6 F 347 G.S6.02
Van-der-waals TM5 H 232 5x73 G.S6 F 347 G.S6.02
Hydrophobic ICL2 P 138 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 138 - G.H5 I 370 G.H5.15
Hydrophobic ICL2 F 139 - G.H5 V 366 G.H5.11
Hydrophobic TM6 A 237 6x22 G.h4s6 K 344 G.h4s6.19
Ionic C-term H 395 - H.HA D 110 H.HA.24
Polar C-term H 395 - H.HA D 110 H.HA.24
Van-der-waals C-term H 395 - H.HA D 110 H.HA.24
Polar ICL2 R 142 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 R 142 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 142 - G.H5 N 374 G.H5.19
Polar TM4 S 144 4x38 G.HN R 52 G.HN.52
Hydrophobic TM4 S 144 4x38 G.HN R 52 G.HN.52
Van-der-waals TM4 S 144 4x38 G.HN R 52 G.HN.52
Ionic TM5 R 227 5x68 G.H5 D 368 G.H5.13
Polar TM5 R 227 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 227 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM6 F 248 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 F 248 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM2 T 68 2x39 G.H5 I 378 G.H5.23
Hydrophobic C-term V 396 - H.HA A 111 H.HA.25
Polar TM6 H 241 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 H 241 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 H 241 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM5 P 230 5x71 G.H5 H 364 G.H5.09
Hydrophobic C-term I 398 - H.HD E 172 H.HD.12
Van-der-waals C-term I 398 - H.HD E 172 H.HD.12
Hydrophobic TM6 M 245 6x30 G.H5 L 375 G.H5.20
Van-der-waals TM6 M 245 6x30 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 138 - G.H5 L 371 G.H5.16
Polar TM5 G 231 5x72 G.S6 H 348 G.S6.03
Hydrophobic TM5 G 231 5x72 G.S6 H 348 G.S6.03
Van-der-waals TM5 G 231 5x72 G.S6 H 348 G.S6.03
Hydrophobic TM3 I 135 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 F 139 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 139 - G.H5 I 370 G.H5.15
Ionic ICL2 R 142 - G.H5 D 377 G.H5.22
Hydrophobic ICL2 R 142 - G.H5 D 377 G.H5.22
Polar C-term H 395 - H.HA K 114 H.HA.28
Van-der-waals C-term H 395 - H.HA K 114 H.HA.28
Hydrophobic C-term I 398 - H.HA A 111 H.HA.25
Hydrophobic C-term I 398 - H.HA L 115 H.HA.29
Van-der-waals C-term I 398 - H.HA L 115 H.HA.29
Van-der-waals TM7 L 310 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 244 6x29 G.H5 M 379 G.H5.24
Ionic ICL3 H 235 - G.H4 D 336 G.H4.16
Polar ICL3 H 235 - G.H4 D 336 G.H4.16
Hydrophobic ICL3 H 235 - G.H4 D 336 G.H4.16
Van-der-waals ICL3 H 235 - G.H4 D 336 G.H4.16
Hydrophobic TM6 A 237 6x22 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 F 139 - G.S1 V 58 G.S1.02
Hydrophobic TM3 A 134 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 134 3x53 G.H5 I 378 G.H5.23
Polar ICL2 P 138 - G.H5 N 374 G.H5.19
Polar C-term S 345 - G.h2s4 D 243 G.h2s4.02
Hydrophobic C-term S 345 - G.h2s4 D 243 G.h2s4.02
Van-der-waals C-term S 345 - G.h2s4 D 243 G.h2s4.02
Hydrophobic TM3 I 135 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 135 3x54 G.H5 L 371 G.H5.16
Hydrophobic C-term V 348 - G.H2 F 239 G.H2.08
Polar TM3 R 131 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM5 L 224 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM6 A 237 6x22 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 A 237 6x22 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 H 241 6x26 G.H5 L 375 G.H5.20
Van-der-waals TM4 P 146 4x40 G.HN R 52 G.HN.52
Hydrophobic TM6 M 245 6x30 G.H5 M 379 G.H5.24
Van-der-waals TM6 M 245 6x30 G.H5 M 379 G.H5.24
Hydrophobic TM5 P 230 5x71 G.H5 F 361 G.H5.06
Van-der-waals H8 H 312 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 F 314 8x50 G.H5 L 380 G.H5.25
Van-der-waals H8 F 314 8x50 G.H5 L 380 G.H5.25
Polar TM3 A 134 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 134 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 138 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 138 - G.H5 K 367 G.H5.12
Hydrophobic C-term W 383 - G.H2 Q 236 G.H2.05
Polar H8 N 311 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 311 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 311 8x47 G.H5 Q 381 G.H5.26
Hydrophobic TM5 H 232 5x73 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 H 232 5x73 G.h4s6 P 345 G.h4s6.20
Hydrophobic C-term L 344 - G.H3 L 285 G.H3.17
Polar H8 R 313 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 R 313 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 R 313 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM5 V 229 5x70 G.S6 F 347 G.S6.02
Van-der-waals TM5 V 229 5x70 G.S6 F 347 G.S6.02
Hydrophobic C-term V 396 - H.hdhe F 173 H.hdhe.01
Van-der-waals C-term V 396 - H.hdhe F 173 H.hdhe.01
Hydrophobic TM7 Y 307 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 307 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM2 I 72 2x43 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 139 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 139 - G.H5 K 367 G.H5.12
Hydrophobic TM5 L 224 5x65 G.H5 L 371 G.H5.16
Aromatic C-term H 352 - G.H2 F 239 G.H2.08
Hydrophobic C-term H 352 - G.H2 F 239 G.H2.08
Van-der-waals C-term H 352 - G.H2 F 239 G.H2.08
Polar TM5 H 232 5x73 G.S6 L 346 G.S6.01
Hydrophobic TM5 H 232 5x73 G.S6 L 346 G.S6.01
Van-der-waals TM5 H 232 5x73 G.S6 L 346 G.S6.01