G12 - BB1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 76.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 N 79 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 N 79 2x40 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 148 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 148 34x50 G.H5 K 367 G.H5.12
Polar TM2 R 103 2x63 G.HN L 8 G.HN.08
Hydrophobic TM2 R 103 2x63 G.HN L 8 G.HN.08
Van-der-waals TM2 R 103 2x63 G.HN L 8 G.HN.08
Hydrophobic ICL3 P 247 - G.H5 H 364 G.H5.09
Hydrophobic TM3 L 124 3x33 G.HN L 12 G.HN.12
Van-der-waals TM3 L 124 3x33 G.HN L 12 G.HN.12
Hydrophobic ICL3 P 247 - G.H5 A 365 G.H5.10
Hydrophobic ICL2 M 149 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 M 149 34x51 G.S3 I 221 G.S3.01
Hydrophobic ECL2 F 195 - G.HN G 3 G.HN.03
Hydrophobic TM6 L 264 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM7 M 303 7x31 G.HN V 4 G.HN.04
Hydrophobic TM3 I 119 3x28 G.HN L 13 G.HN.13
Van-der-waals TM3 I 119 3x28 G.HN L 13 G.HN.13
Hydrophobic TM6 R 261 6x30 G.H5 L 375 G.H5.20
Hydrophobic ICL2 T 153 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 T 153 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 P 120 3x29 G.HN L 12 G.HN.12
Van-der-waals TM3 P 120 3x29 G.HN L 12 G.HN.12
Ionic TM6 R 261 6x30 G.H5 D 368 G.H5.13
Polar TM6 R 261 6x30 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 261 6x30 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 261 6x30 G.H5 D 368 G.H5.13
Hydrophobic ICL2 M 149 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 M 149 34x51 G.H5 F 363 G.H5.08
Polar H8 E 329 8x48 G.H5 L 380 G.H5.25
Hydrophobic ECL2 A 197 - G.HN T 7 G.HN.07
Van-der-waals ECL2 A 197 - G.HN T 7 G.HN.07
Hydrophobic TM1 G 35 1x24 G.HN M 1 G.HN.01
Van-der-waals TM1 G 35 1x24 G.HN M 1 G.HN.01
Hydrophobic ICL3 L 246 - G.H5 D 368 G.H5.13
Hydrophobic TM3 R 141 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL3 P 247 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 P 247 - G.S6 F 347 G.S6.02
Hydrophobic TM2 V 99 2x59 G.HN C 11 G.HN.11
Van-der-waals TM2 V 99 2x59 G.HN C 11 G.HN.11
Polar TM6 Q 257 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 Q 257 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 Q 257 6x26 G.H5 Q 372 G.H5.17
Polar TM2 C 96 2x56 G.HN C 11 G.HN.11
Hydrophobic TM2 C 96 2x56 G.HN C 11 G.HN.11
Van-der-waals TM2 C 96 2x56 G.HN C 11 G.HN.11
Hydrophobic TM3 P 120 3x29 G.HN R 10 G.HN.10
Polar ECL1 D 107 - G.HN G 3 G.HN.03
Hydrophobic ECL1 D 107 - G.HN G 3 G.HN.03
Hydrophobic TM6 Y 286 6x55 G.HN L 8 G.HN.08
Van-der-waals TM6 Y 286 6x55 G.HN L 8 G.HN.08
Hydrophobic ICL2 P 148 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 148 34x50 G.H5 I 370 G.H5.15
Polar TM2 V 99 2x59 G.HN S 9 G.HN.09
Hydrophobic TM2 V 99 2x59 G.HN S 9 G.HN.09
Van-der-waals TM2 V 99 2x59 G.HN S 9 G.HN.09
Polar ECL1 D 107 - G.HN M 1 G.HN.01
Van-der-waals ECL1 D 107 - G.HN M 1 G.HN.01
Polar ICL2 P 148 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 148 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 148 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 M 151 34x53 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 M 151 34x53 G.hns1 R 56 G.hns1.03
Hydrophobic TM2 Y 104 2x64 G.HN V 4 G.HN.04
Van-der-waals TM2 Y 104 2x64 G.HN V 4 G.HN.04
Hydrophobic TM1 F 68 1x57 G.H5 L 380 G.H5.25
Van-der-waals TM1 F 68 1x57 G.H5 L 380 G.H5.25
Polar TM3 Q 123 3x32 G.HN R 10 G.HN.10
Hydrophobic TM3 Q 123 3x32 G.HN R 10 G.HN.10
Van-der-waals TM3 Q 123 3x32 G.HN R 10 G.HN.10
Polar TM5 H 212 5x39 G.HN R 10 G.HN.10
Van-der-waals TM5 H 212 5x39 G.HN R 10 G.HN.10
Hydrophobic ECL2 P 200 45x52 G.HN R 10 G.HN.10
Van-der-waals ECL2 P 200 45x52 G.HN R 10 G.HN.10
Polar TM2 D 100 2x60 G.HN C 11 G.HN.11
Hydrophobic TM2 D 100 2x60 G.HN C 11 G.HN.11
Van-der-waals TM2 D 100 2x60 G.HN C 11 G.HN.11
Hydrophobic TM2 T 95 2x551 G.HN L 12 G.HN.12
Van-der-waals TM2 T 95 2x551 G.HN L 12 G.HN.12
Hydrophobic ECL3 P 298 - G.HN V 5 G.HN.05
Polar H8 S 328 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 328 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 328 8x47 G.H5 L 380 G.H5.25
Polar TM6 R 289 6x58 G.HN V 5 G.HN.05
Hydrophobic TM6 R 289 6x58 G.HN V 5 G.HN.05
Van-der-waals TM6 R 289 6x58 G.HN V 5 G.HN.05
Hydrophobic ICL2 M 149 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM3 I 122 3x31 G.HN L 12 G.HN.12
Van-der-waals TM3 I 122 3x31 G.HN L 12 G.HN.12
Hydrophobic ECL3 I 296 - G.HN V 5 G.HN.05
Van-der-waals ECL3 I 296 - G.HN V 5 G.HN.05
Polar ICL2 S 154 34x56 G.HN A 48 G.HN.48
Van-der-waals ICL2 S 154 34x56 G.HN A 48 G.HN.48
Ionic TM6 E 249 6x18 G.S6 H 348 G.S6.03
Polar TM6 E 249 6x18 G.S6 H 348 G.S6.03
Hydrophobic TM6 E 249 6x18 G.S6 H 348 G.S6.03
Van-der-waals TM6 E 249 6x18 G.S6 H 348 G.S6.03
Hydrophobic ICL3 G 248 - G.S6 L 346 G.S6.01
Van-der-waals ICL3 G 248 - G.S6 L 346 G.S6.01
Polar TM2 R 103 2x63 G.HN S 9 G.HN.09
Hydrophobic TM2 R 103 2x63 G.HN S 9 G.HN.09
Van-der-waals TM2 R 103 2x63 G.HN S 9 G.HN.09
Polar TM3 A 144 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 144 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 144 3x53 G.H5 N 374 G.H5.19
Hydrophobic ECL2 I 187 - G.HN R 6 G.HN.06
Hydrophobic ICL2 M 151 34x53 G.H5 N 374 G.H5.19
Van-der-waals ICL2 M 151 34x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 144 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM3 I 145 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM6 L 264 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 L 264 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM7 H 302 7x30 G.HN V 5 G.HN.05
Hydrophobic ECL3 I 296 - G.HN R 6 G.HN.06
Van-der-waals ECL3 I 296 - G.HN R 6 G.HN.06
Polar TM3 I 119 3x28 G.HN L 12 G.HN.12
Hydrophobic TM3 I 119 3x28 G.HN L 12 G.HN.12
Van-der-waals TM3 I 119 3x28 G.HN L 12 G.HN.12
Hydrophobic TM4 L 158 4x40 G.HN R 52 G.HN.52
Van-der-waals TM4 L 158 4x40 G.HN R 52 G.HN.52
Polar TM3 Q 123 3x32 G.HN C 11 G.HN.11
Hydrophobic TM3 Q 123 3x32 G.HN C 11 G.HN.11
Van-der-waals TM3 Q 123 3x32 G.HN C 11 G.HN.11
Hydrophobic ICL2 S 154 34x56 G.HN R 51 G.HN.51
Van-der-waals ICL2 S 154 34x56 G.HN R 51 G.HN.51
Polar TM2 R 103 2x63 G.HN T 7 G.HN.07
Hydrophobic TM2 R 103 2x63 G.HN T 7 G.HN.07
Van-der-waals TM2 R 103 2x63 G.HN T 7 G.HN.07
Polar TM3 L 118 3x27 G.HN L 13 G.HN.13
Hydrophobic TM3 L 118 3x27 G.HN L 13 G.HN.13
Van-der-waals TM3 L 118 3x27 G.HN L 13 G.HN.13
Hydrophobic ICL2 G 155 34x57 G.HN R 52 G.HN.52
Van-der-waals ICL2 G 155 34x57 G.HN R 52 G.HN.52
Polar TM5 S 242 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 S 242 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM3 G 115 3x24 G.HN L 13 G.HN.13
Van-der-waals TM3 G 115 3x24 G.HN L 13 G.HN.13
Hydrophobic TM3 I 145 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 M 149 34x51 G.H5 K 367 G.H5.12
Polar ICL3 N 245 - G.H5 H 364 G.H5.09
Hydrophobic ICL3 N 245 - G.H5 H 364 G.H5.09
Van-der-waals ICL3 N 245 - G.H5 H 364 G.H5.09
Polar TM7 R 310 7x38 G.HN S 9 G.HN.09
Van-der-waals TM7 R 310 7x38 G.HN S 9 G.HN.09
Hydrophobic TM5 S 242 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 S 242 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM2 V 99 2x59 G.HN R 10 G.HN.10
Hydrophobic TM3 Q 123 3x32 G.HN L 12 G.HN.12
Van-der-waals TM3 Q 123 3x32 G.HN L 12 G.HN.12
Hydrophobic ICL2 Q 152 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 I 119 3x28 G.HN R 10 G.HN.10
Van-der-waals TM3 I 119 3x28 G.HN R 10 G.HN.10
Polar ICL2 S 154 34x56 G.HN R 52 G.HN.52
Hydrophobic ICL2 S 154 34x56 G.HN R 52 G.HN.52
Van-der-waals ICL2 S 154 34x56 G.HN R 52 G.HN.52
Hydrophobic TM3 V 121 3x30 G.HN L 12 G.HN.12
Van-der-waals TM3 V 121 3x30 G.HN L 12 G.HN.12
Hydrophobic TM3 V 114 3x23 G.HN L 13 G.HN.13
Van-der-waals TM3 V 114 3x23 G.HN L 13 G.HN.13
Hydrophobic ICL2 M 149 34x51 G.S3 F 223 G.S3.03
Hydrophobic TM5 L 239 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL3 P 247 - G.H5 D 368 G.H5.13
Hydrophobic ICL2 P 148 34x50 G.H5 L 371 G.H5.16
Polar TM2 D 100 2x60 G.HN S 9 G.HN.09
Hydrophobic TM2 D 100 2x60 G.HN S 9 G.HN.09
Hydrophobic ICL2 M 149 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 M 149 34x51 G.H5 I 370 G.H5.15
Polar TM3 I 119 3x28 G.HN C 11 G.HN.11
Hydrophobic TM3 I 119 3x28 G.HN C 11 G.HN.11
Van-der-waals TM3 I 119 3x28 G.HN C 11 G.HN.11
Polar TM6 E 249 6x18 G.S6 L 346 G.S6.01
Polar TM6 R 261 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 261 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM6 E 249 6x18 G.H4 V 332 G.H4.12
Van-der-waals TM6 E 249 6x18 G.H4 V 332 G.H4.12
Polar TM3 V 146 3x55 G.H5 K 367 G.H5.12
Van-der-waals TM3 V 146 3x55 G.H5 K 367 G.H5.12
Hydrophobic TM3 I 145 3x54 G.H5 L 371 G.H5.16
Polar H8 S 330 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 S 330 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 S 330 8x49 G.H5 L 380 G.H5.25
Polar TM6 H 253 6x22 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 H 253 6x22 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 H 253 6x22 G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL3 G 248 - G.S6 F 347 G.S6.02
Hydrophobic TM6 T 260 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 260 6x29 G.H5 M 379 G.H5.24
Polar TM2 T 95 2x551 G.HN C 11 G.HN.11
Hydrophobic TM2 T 95 2x551 G.HN C 11 G.HN.11
Van-der-waals TM2 T 95 2x551 G.HN C 11 G.HN.11
Polar TM1 E 39 1x28 G.HN M 1 G.HN.01
Hydrophobic TM1 E 39 1x28 G.HN M 1 G.HN.01
Van-der-waals TM1 E 39 1x28 G.HN M 1 G.HN.01
Polar H8 S 328 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 S 328 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 S 328 8x47 G.H5 M 379 G.H5.24
Ionic TM4 E 178 4x61 G.HN R 10 G.HN.10
Polar TM4 E 178 4x61 G.HN R 10 G.HN.10
Hydrophobic TM4 E 178 4x61 G.HN R 10 G.HN.10
Van-der-waals TM4 E 178 4x61 G.HN R 10 G.HN.10
Hydrophobic TM3 L 118 3x27 G.HN L 12 G.HN.12
Van-der-waals TM3 L 118 3x27 G.HN L 12 G.HN.12
Polar TM3 Q 123 3x32 G.HN S 9 G.HN.09
Hydrophobic TM3 Q 123 3x32 G.HN S 9 G.HN.09
Van-der-waals TM3 Q 123 3x32 G.HN S 9 G.HN.09
Polar ECL3 Y 293 - G.HN R 6 G.HN.06
Aromatic ECL3 Y 293 - G.HN R 6 G.HN.06
Hydrophobic ECL3 Y 293 - G.HN R 6 G.HN.06
Van-der-waals ECL3 Y 293 - G.HN R 6 G.HN.06
Hydrophobic TM2 P 78 2x39 G.H5 I 378 G.H5.23