G15 - OR51B2 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Van-der-waals ICL1 S 52 12x49 G.H5 I 371 G.H5.23
Hydrophobic ICL2 Y 130 34x53 G.H5 L 368 G.H5.20
Van-der-waals ICL2 Y 130 34x53 G.H5 L 368 G.H5.20
Hydrophobic H8 Q 296 8x49 G.h4s6 R 335 G.h4s6.17
Van-der-waals H8 Q 296 8x49 G.h4s6 R 335 G.h4s6.17
Polar ICL2 S 132 34x55 G.s2s3 Q 200 G.s2s3.01
Hydrophobic ICL2 S 132 34x55 G.s2s3 Q 200 G.s2s3.01
Van-der-waals ICL2 S 132 34x55 G.s2s3 Q 200 G.s2s3.01
Polar ICL2 S 132 34x55 G.S3 T 202 G.S3.01
Hydrophobic ICL2 S 132 34x55 G.S3 T 202 G.S3.01
Van-der-waals ICL2 S 132 34x55 G.S3 T 202 G.S3.01
Polar TM6 K 234 6x32 G.h4s6 S 336 G.h4s6.18
Van-der-waals TM6 K 234 6x32 G.h4s6 S 336 G.h4s6.18
Hydrophobic ICL1 L 53 12x50 G.H5 N 372 G.H5.24
Polar ICL2 A 131 34x54 G.S3 T 202 G.S3.01
Hydrophobic ICL2 A 131 34x54 G.S3 T 202 G.S3.01
Van-der-waals ICL2 A 131 34x54 G.S3 T 202 G.S3.01
Hydrophobic TM2 P 56 2x38 G.H5 L 373 G.H5.25
Van-der-waals TM2 P 56 2x38 G.H5 L 373 G.H5.25
Hydrophobic TM2 M 57 2x39 G.H5 L 374 G.H5.26
Polar ICL2 P 127 34x50 G.H5 D 361 G.H5.13
Hydrophobic ICL2 P 127 34x50 G.H5 D 361 G.H5.13
Van-der-waals ICL2 P 127 34x50 G.H5 D 361 G.H5.13
Hydrophobic ICL2 L 128 34x51 G.H5 F 356 G.H5.08
Van-der-waals ICL2 L 128 34x51 G.H5 F 356 G.H5.08
Ionic TM6 K 234 6x32 G.H5 D 369 G.H5.21
Polar TM6 K 234 6x32 G.H5 D 369 G.H5.21
Hydrophobic TM6 K 234 6x32 G.H5 D 369 G.H5.21
Van-der-waals TM6 K 234 6x32 G.H5 D 369 G.H5.21
Polar TM3 N 126 3x56 G.H5 K 357 G.H5.09
Hydrophobic TM3 N 126 3x56 G.H5 K 357 G.H5.09
Van-der-waals TM3 N 126 3x56 G.H5 K 357 G.H5.09
Hydrophobic TM2 E 55 2x37 G.H5 I 371 G.H5.23
Van-der-waals TM2 E 55 2x37 G.H5 I 371 G.H5.23
Polar ICL1 H 51 12x48 G.hns1 R 40 G.hns1.02
Hydrophobic ICL1 H 51 12x48 G.hns1 R 40 G.hns1.02
Van-der-waals ICL1 H 51 12x48 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 P 127 34x50 G.H5 L 364 G.H5.16
Van-der-waals ICL2 P 127 34x50 G.H5 L 364 G.H5.16
Polar ICL2 L 128 34x51 G.H5 D 361 G.H5.13
Hydrophobic ICL2 L 128 34x51 G.H5 D 361 G.H5.13
Van-der-waals ICL2 L 128 34x51 G.H5 D 361 G.H5.13
Hydrophobic ICL2 Y 130 34x53 G.H5 L 373 G.H5.25
Van-der-waals ICL2 Y 130 34x53 G.H5 L 373 G.H5.25
Polar TM2 Y 58 2x40 G.H5 N 372 G.H5.24
Hydrophobic TM2 Y 58 2x40 G.H5 N 372 G.H5.24
Van-der-waals TM2 Y 58 2x40 G.H5 N 372 G.H5.24
Hydrophobic TM3 A 123 3x53 G.H5 L 374 G.H5.26
Hydrophobic ICL2 L 128 34x51 G.H5 V 359 G.H5.11
Polar TM2 E 55 2x37 G.H5 N 372 G.H5.24
Polar TM2 E 55 2x37 G.H5 L 373 G.H5.25
Hydrophobic TM2 E 55 2x37 G.H5 L 373 G.H5.25
Van-der-waals TM2 E 55 2x37 G.H5 L 373 G.H5.25
Hydrophobic TM2 Y 58 2x40 G.H5 L 373 G.H5.25
Van-der-waals TM2 Y 58 2x40 G.H5 L 373 G.H5.25
Hydrophobic TM3 N 126 3x56 G.H5 D 361 G.H5.13
Van-der-waals TM3 N 126 3x56 G.H5 D 361 G.H5.13
Polar H8 K 295 8x48 G.h4s6 K 332 G.h4s6.14
Van-der-waals H8 K 295 8x48 G.h4s6 K 332 G.h4s6.14
Polar ICL2 R 129 34x52 G.s2s3 Q 200 G.s2s3.01
Hydrophobic ICL2 R 129 34x52 G.s2s3 Q 200 G.s2s3.01
Van-der-waals ICL2 R 129 34x52 G.s2s3 Q 200 G.s2s3.01
Hydrophobic ICL2 P 127 34x50 G.H5 A 365 G.H5.17
Van-der-waals ICL2 P 127 34x50 G.H5 A 365 G.H5.17
Hydrophobic TM3 A 123 3x53 G.H5 A 365 G.H5.17
Van-der-waals TM3 A 123 3x53 G.H5 A 365 G.H5.17
Hydrophobic TM6 T 238 6x36 G.H5 L 374 G.H5.26
Van-der-waals TM6 T 238 6x36 G.H5 L 374 G.H5.26
Hydrophobic TM2 M 57 2x39 G.H5 L 373 G.H5.25
Van-der-waals TM2 M 57 2x39 G.H5 L 373 G.H5.25
Polar ICL1 S 52 12x49 G.H5 N 372 G.H5.24
Hydrophobic ICL1 S 52 12x49 G.H5 N 372 G.H5.24
Van-der-waals ICL1 S 52 12x49 G.H5 N 372 G.H5.24
Polar H8 Q 296 8x49 G.H5 N 372 G.H5.24
Hydrophobic H8 Q 296 8x49 G.H5 N 372 G.H5.24
Van-der-waals H8 Q 296 8x49 G.H5 N 372 G.H5.24
Polar ICL2 L 128 34x51 G.H5 R 360 G.H5.12
Hydrophobic ICL2 L 128 34x51 G.H5 R 360 G.H5.12
Van-der-waals ICL2 L 128 34x51 G.H5 R 360 G.H5.12
Hydrophobic TM2 E 55 2x37 G.H5 L 368 G.H5.20
Van-der-waals TM2 E 55 2x37 G.H5 L 368 G.H5.20
Hydrophobic ICL2 A 131 34x54 G.H5 L 364 G.H5.16
Van-der-waals ICL2 A 131 34x54 G.H5 L 364 G.H5.16
Polar H8 K 295 8x48 G.h4s6 G 333 G.h4s6.15
Polar H8 Q 296 8x49 G.H5 D 369 G.H5.21
Van-der-waals H8 Q 296 8x49 G.H5 D 369 G.H5.21
Hydrophobic ICL2 L 128 34x51 G.H5 K 357 G.H5.09
Van-der-waals ICL2 L 128 34x51 G.H5 K 357 G.H5.09
Hydrophobic ICL2 L 128 34x51 G.H5 L 364 G.H5.16
Van-der-waals ICL2 L 128 34x51 G.H5 L 364 G.H5.16
Hydrophobic TM6 K 234 6x32 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM6 K 234 6x32 G.h4s6 R 338 G.h4s6.20
Hydrophobic ICL2 L 128 34x51 G.H5 D 358 G.H5.10
Van-der-waals ICL2 L 128 34x51 G.H5 D 358 G.H5.10
Van-der-waals TM6 E 231 6x29 G.S6 L 339 G.S6.01
Hydrophobic TM6 E 231 6x29 G.S6 F 340 G.S6.02
Van-der-waals TM6 E 231 6x29 G.S6 F 340 G.S6.02
Polar H8 Y 299 8x52 G.h4s6 G 333 G.h4s6.15
Polar TM3 R 125 3x55 G.H5 K 357 G.H5.09
Hydrophobic ICL2 P 127 34x50 G.H5 R 360 G.H5.12