Gi3 - OR51D1 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 84.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 20.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 143 34x51 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 L 143 34x51 G.hns1 A 31 G.hns1.02
Hydrophobic TM2 M 72 2x39 G.H5 L 353 G.H5.25
Polar ICL2 S 147 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 S 147 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 S 147 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 L 143 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 143 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 P 142 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM6 A 246 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 A 246 6x29 G.H5 K 345 G.H5.17
Hydrophobic ICL2 A 146 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 A 146 34x54 G.hns1 A 31 G.hns1.02
Polar ICL3 S 242 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 142 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 142 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 K 249 6x32 G.H5 K 349 G.H5.21
Van-der-waals TM6 K 249 6x32 G.H5 K 349 G.H5.21
Hydrophobic ICL2 R 144 34x52 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 R 144 34x52 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 L 143 34x51 G.S1 V 34 G.S1.02
Van-der-waals ICL2 L 143 34x51 G.S1 V 34 G.S1.02
Polar TM6 T 253 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 253 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 253 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 138 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 138 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM6 T 253 6x36 G.H5 Y 354 G.H5.26
Hydrophobic TM3 A 138 3x53 G.H5 L 348 G.H5.20
Van-der-waals TM3 A 138 3x53 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 143 34x51 G.H5 I 343 G.H5.15
Van-der-waals TM2 E 70 2x37 G.H5 E 350 G.H5.22
Hydrophobic TM3 R 135 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 135 3x50 G.H5 L 353 G.H5.25
Ionic ICL2 R 144 34x52 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 144 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 144 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 144 34x52 G.s2s3 D 193 G.s2s3.02
Polar H8 K 309 8x48 G.H5 Y 354 G.H5.26
Hydrophobic TM3 A 138 3x53 G.H5 L 353 G.H5.25
Van-der-waals TM3 A 138 3x53 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 143 34x51 G.H5 N 347 G.H5.19
Van-der-waals ICL2 L 143 34x51 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 143 34x51 G.h2s4 T 219 G.h2s4.05
Polar ICL2 S 147 34x55 G.HN G 27 G.HN.51
Hydrophobic ICL2 S 147 34x55 G.HN G 27 G.HN.51
Van-der-waals ICL2 S 147 34x55 G.HN G 27 G.HN.51
Polar ICL2 R 144 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 144 34x52 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 144 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic TM2 E 70 2x37 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 139 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 139 3x54 G.H5 L 348 G.H5.20
Polar ICL2 H 145 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 H 145 34x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 H 145 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 143 34x51 G.H5 I 344 G.H5.16
Polar TM2 Y 73 2x40 G.H5 G 352 G.H5.24
Hydrophobic TM2 Y 73 2x40 G.H5 G 352 G.H5.24
Van-der-waals TM2 Y 73 2x40 G.H5 G 352 G.H5.24
Hydrophobic TM6 K 249 6x32 G.H5 K 345 G.H5.17
Van-der-waals TM6 K 249 6x32 G.H5 K 345 G.H5.17
Hydrophobic TM2 M 72 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 M 72 2x39 G.H5 C 351 G.H5.23
Polar TM6 K 249 6x32 G.H5 Y 354 G.H5.26
Aromatic TM6 K 249 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 249 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 249 6x32 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 P 142 34x50 G.H5 L 348 G.H5.20
Hydrophobic ICL2 S 147 34x55 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 S 147 34x55 G.hns1 A 31 G.hns1.02