Gs - OR51D1 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 R 144 34x52 G.s2s3 K 216 G.s2s3.02
Polar TM6 A 250 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 250 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 250 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 246 6x29 G.H5 L 394 G.H5.26
Polar ICL2 R 144 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 R 144 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 144 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic TM6 T 253 6x36 G.H5 Y 391 G.H5.23
Van-der-waals TM6 T 253 6x36 G.H5 Y 391 G.H5.23
Hydrophobic TM7 K 307 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 K 307 7x56 G.H5 E 392 G.H5.24
Hydrophobic ICL2 S 147 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM3 I 139 3x54 G.H5 L 393 G.H5.25
Polar TM6 T 253 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 253 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 253 6x36 G.H5 E 392 G.H5.24
Polar H8 T 308 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 T 308 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 T 308 8x47 G.H5 E 392 G.H5.24
Polar TM3 I 139 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 139 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 139 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 143 34x51 G.H5 I 383 G.H5.15
Polar TM6 K 249 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 249 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 249 6x32 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 143 34x51 G.H5 C 379 G.H5.11
Hydrophobic ICL2 P 142 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 L 241 - G.H5 Q 384 G.H5.16
Van-der-waals ICL3 L 241 - G.H5 Q 384 G.H5.16
Hydrophobic TM3 A 138 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 138 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 L 241 - G.H5 L 388 G.H5.20
Hydrophobic TM6 C 254 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 C 254 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM3 R 135 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 143 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 143 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM6 A 250 6x33 G.H5 L 388 G.H5.20
Van-der-waals TM6 A 250 6x33 G.H5 L 388 G.H5.20
Polar H8 K 309 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 309 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 309 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 143 34x51 G.S3 F 219 G.S3.03
Polar TM4 T 150 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM4 T 150 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 T 150 4x38 G.HN Q 35 G.HN.52
Polar TM6 T 253 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 253 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 253 6x36 G.H5 L 393 G.H5.25
Polar TM3 A 138 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 138 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 138 3x53 G.H5 H 387 G.H5.19
Polar ICL2 H 145 34x53 G.H5 H 387 G.H5.19
Aromatic ICL2 H 145 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 H 145 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 H 145 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 142 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 142 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL2 A 146 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 A 146 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM3 I 139 3x54 G.H5 L 388 G.H5.20
Polar TM3 D 134 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 134 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 134 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 144 34x52 G.S3 V 217 G.S3.01
Polar ICL2 L 143 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 143 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 143 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 143 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM2 M 72 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 M 72 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 142 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 142 34x50 G.H5 I 383 G.H5.15
Polar TM2 E 70 2x37 G.H5 Q 390 G.H5.22
Hydrophobic TM2 E 70 2x37 G.H5 Q 390 G.H5.22
Van-der-waals TM2 E 70 2x37 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 A 146 34x54 G.hns1 A 39 G.hns1.03
Polar ICL2 H 145 34x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 143 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 143 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 P 142 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 142 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM6 K 249 6x32 G.H5 L 393 G.H5.25
Van-der-waals TM6 K 249 6x32 G.H5 L 393 G.H5.25