Gz - OR51F2 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 82.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic H8 Q 312 8x49 G.H5 G 353 G.H5.24
Polar TM6 T 254 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM6 T 254 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 254 6x36 G.H5 L 354 G.H5.25
Polar ICL2 T 148 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 T 148 34x55 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 T 148 34x55 G.hns1 R 31 G.hns1.02
Polar TM4 T 151 4x38 G.hns1 R 31 G.hns1.02
Hydrophobic TM4 T 151 4x38 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 T 151 4x38 G.hns1 R 31 G.hns1.02
Hydrophobic TM3 A 139 3x53 G.H5 L 349 G.H5.20
Van-der-waals TM3 A 139 3x53 G.H5 L 349 G.H5.20
Hydrophobic ICL2 P 143 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 143 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM2 M 73 2x39 G.H5 I 352 G.H5.23
Van-der-waals TM2 M 73 2x39 G.H5 I 352 G.H5.23
Ionic ICL2 R 145 34x52 G.s2s3 E 194 G.s2s3.02
Polar ICL2 R 145 34x52 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 R 145 34x52 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 R 145 34x52 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 L 144 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 144 34x51 G.H5 I 344 G.H5.15
Hydrophobic ICL2 R 145 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 144 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 L 144 34x51 G.H5 T 341 G.H5.12
Hydrophobic TM3 A 139 3x53 G.H5 I 352 G.H5.23
Van-der-waals TM3 A 139 3x53 G.H5 I 352 G.H5.23
Hydrophobic ICL2 P 143 34x50 G.H5 L 349 G.H5.20
Van-der-waals ICL2 P 143 34x50 G.H5 L 349 G.H5.20
Hydrophobic TM3 A 139 3x53 G.H5 L 354 G.H5.25
Hydrophobic TM6 K 250 6x32 G.H5 C 355 G.H5.26
Hydrophobic TM3 I 140 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 140 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM3 R 136 3x50 G.H5 L 354 G.H5.25
Polar TM2 K 71 2x37 G.H5 Y 351 G.H5.22
Hydrophobic TM2 K 71 2x37 G.H5 Y 351 G.H5.22
Van-der-waals TM2 K 71 2x37 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 L 144 34x51 G.S1 I 34 G.S1.02
Van-der-waals ICL2 L 144 34x51 G.S1 I 34 G.S1.02
Hydrophobic ICL2 Y 146 34x53 G.H5 I 352 G.H5.23
Van-der-waals ICL2 Y 146 34x53 G.H5 I 352 G.H5.23
Hydrophobic ICL2 L 144 34x51 G.H5 I 345 G.H5.16
Van-der-waals ICL2 L 144 34x51 G.H5 I 345 G.H5.16
Ionic H8 K 315 8x52 G.h4s6 E 316 G.h4s6.09
Polar H8 K 315 8x52 G.h4s6 E 316 G.h4s6.09
Hydrophobic ICL2 L 144 34x51 G.h2s4 T 220 G.h2s4.05
Polar TM6 T 254 6x36 G.H5 C 355 G.H5.26
Polar TM6 E 247 6x29 G.H5 Q 346 G.H5.17
Hydrophobic TM6 E 247 6x29 G.H5 Q 346 G.H5.17
Van-der-waals TM6 E 247 6x29 G.H5 Q 346 G.H5.17
Hydrophobic ICL2 L 144 34x51 G.S3 F 197 G.S3.03
Hydrophobic ICL2 P 143 34x50 G.H5 Q 346 G.H5.17
Polar ICL2 P 143 34x50 G.H5 N 348 G.H5.19
Hydrophobic ICL2 P 143 34x50 G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 143 34x50 G.H5 N 348 G.H5.19
Hydrophobic ICL2 R 145 34x52 G.S3 L 195 G.S3.01
Van-der-waals ICL2 R 145 34x52 G.S3 L 195 G.S3.01
Hydrophobic TM3 D 135 3x49 G.H5 I 352 G.H5.23
Van-der-waals TM3 D 135 3x49 G.H5 I 352 G.H5.23
Hydrophobic TM2 Y 74 2x40 G.H5 G 353 G.H5.24
Van-der-waals TM2 Y 74 2x40 G.H5 G 353 G.H5.24
Hydrophobic ICL2 L 144 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 144 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM6 K 250 6x32 G.H5 K 350 G.H5.21
Van-der-waals TM6 K 250 6x32 G.H5 K 350 G.H5.21
Hydrophobic TM2 M 73 2x39 G.H5 L 354 G.H5.25
Van-der-waals TM2 M 73 2x39 G.H5 L 354 G.H5.25
Hydrophobic TM2 M 73 2x39 G.H5 G 353 G.H5.24
Van-der-waals TM2 M 73 2x39 G.H5 G 353 G.H5.24