G12 - OR51I2 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar H8 T 296 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 T 296 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 T 296 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM2 Y 60 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 Y 60 2x40 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 129 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 129 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM6 S 243 6x39 G.H5 L 380 G.H5.25
Hydrophobic TM7 Y 292 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 292 7x53 G.H5 L 380 G.H5.25
Polar TM2 Y 61 2x41 G.HN R 52 G.HN.52
Hydrophobic TM2 Y 61 2x41 G.HN R 52 G.HN.52
Van-der-waals TM2 Y 61 2x41 G.HN R 52 G.HN.52
Hydrophobic TM2 E 57 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 E 57 2x37 G.H5 D 377 G.H5.22
Hydrophobic ICL2 T 134 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 T 134 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM2 M 59 2x39 G.H5 L 380 G.H5.25
Van-der-waals TM2 M 59 2x39 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 130 34x51 G.H5 K 367 G.H5.12
Ionic TM2 E 57 2x37 G.hns1 R 55 G.hns1.02
Polar TM2 E 57 2x37 G.hns1 R 55 G.hns1.02
Hydrophobic TM2 E 57 2x37 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 E 57 2x37 G.hns1 R 55 G.hns1.02
Polar ICL1 H 56 12x51 G.HN R 52 G.HN.52
Hydrophobic ICL1 H 56 12x51 G.HN R 52 G.HN.52
Van-der-waals ICL1 H 56 12x51 G.HN R 52 G.HN.52
Hydrophobic H8 K 297 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 297 8x48 G.H5 Q 381 G.H5.26
Hydrophobic ICL1 P 53 12x48 G.HN D 44 G.HN.44
Hydrophobic ICL2 Y 132 34x53 G.H5 N 374 G.H5.19
Van-der-waals ICL2 Y 132 34x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 125 3x53 G.H5 L 371 G.H5.16
Polar TM3 C 127 3x55 G.H5 K 367 G.H5.12
Van-der-waals TM3 C 127 3x55 G.H5 K 367 G.H5.12
Polar TM4 T 138 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 T 138 4x39 G.HN R 52 G.HN.52
Hydrophobic TM6 T 240 6x36 G.H5 I 378 G.H5.23
Van-der-waals TM6 T 240 6x36 G.H5 I 378 G.H5.23
Polar TM3 A 125 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 125 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 125 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 R 122 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 130 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 130 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM4 T 137 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 T 137 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 A 237 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 A 237 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM6 T 240 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 240 6x36 G.H5 M 379 G.H5.24
Hydrophobic ICL2 A 133 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 A 133 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 L 130 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 130 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 L 130 34x51 G.H5 V 366 G.H5.11
Van-der-waals ICL2 L 130 34x51 G.H5 V 366 G.H5.11
Polar ICL2 R 131 34x52 G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 R 131 34x52 G.s2s3 K 219 G.s2s3.01
Hydrophobic TM6 K 236 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 236 6x32 G.H5 M 379 G.H5.24
Polar ICL2 P 129 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 129 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 129 34x50 G.H5 N 374 G.H5.19
Polar TM1 V 51 1x59 G.HN R 41 G.HN.41
Hydrophobic TM1 V 51 1x59 G.HN R 41 G.HN.41
Van-der-waals TM1 V 51 1x59 G.HN R 41 G.HN.41
Hydrophobic TM2 M 59 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 M 59 2x39 G.H5 I 378 G.H5.23
Polar ICL2 A 133 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 A 133 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 A 133 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 L 130 34x51 G.S1 V 58 G.S1.02
Polar H8 E 298 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 E 298 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 E 298 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM6 T 240 6x36 G.H5 L 375 G.H5.20
Hydrophobic TM3 I 126 3x54 G.H5 L 375 G.H5.20
Polar H8 H 309 8x60 G.HN R 37 G.HN.37
Aromatic H8 H 309 8x60 G.HN R 37 G.HN.37
Hydrophobic H8 H 309 8x60 G.HN R 37 G.HN.37
Van-der-waals H8 H 309 8x60 G.HN R 37 G.HN.37
Hydrophobic TM3 I 126 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 126 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 R 131 34x52 G.s2s3 K 220 G.s2s3.02
Polar TM6 K 236 6x32 G.H5 Q 372 G.H5.17
Hydrophobic TM6 K 236 6x32 G.H5 Q 372 G.H5.17
Van-der-waals TM6 K 236 6x32 G.H5 Q 372 G.H5.17
Hydrophobic TM3 A 125 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 125 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 Y 132 34x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 129 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 129 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 R 131 34x52 G.S3 I 221 G.S3.01
Polar H8 K 297 8x48 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 130 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 130 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 P 129 34x50 G.H5 L 371 G.H5.16
Hydrophobic H8 E 298 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 E 298 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM6 K 236 6x32 G.H5 K 376 G.H5.21
Polar TM6 E 233 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM6 E 233 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 E 233 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM7 K 295 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 K 295 7x56 G.H5 L 380 G.H5.25