GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Van-der-waals | TM2 | M | 59 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM6 | T | 240 | 6x36 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM6 | T | 240 | 6x36 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | T | 240 | 6x36 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL2 | R | 131 | 34x52 | G.S3 | V | 199 | G.S3.01 |
Hydrophobic | TM3 | R | 122 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | R | 122 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | D | 128 | 3x56 | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | TM5 | I | 221 | 5x61 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | P | 129 | 34x50 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | ICL2 | P | 129 | 34x50 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM6 | K | 236 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | K | 236 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM6 | E | 233 | 6x29 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | TM6 | E | 233 | 6x29 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | ICL2 | L | 130 | 34x51 | G.hns1 | R | 37 | G.hns1.02 |
Polar | TM6 | T | 240 | 6x36 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM6 | T | 240 | 6x36 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | T | 240 | 6x36 | G.H5 | N | 357 | G.H5.24 |
Polar | ICL2 | T | 134 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | ICL2 | T | 134 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Van-der-waals | ICL2 | T | 134 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Ionic | TM4 | E | 139 | 4x40 | G.HN | R | 30 | G.HN.48 |
Polar | TM4 | E | 139 | 4x40 | G.HN | R | 30 | G.HN.48 |
Hydrophobic | TM4 | E | 139 | 4x40 | G.HN | R | 30 | G.HN.48 |
Van-der-waals | TM4 | E | 139 | 4x40 | G.HN | R | 30 | G.HN.48 |
Polar | TM6 | T | 240 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | T | 240 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | T | 240 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | A | 237 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | A | 237 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Polar | TM6 | C | 241 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | C | 241 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | C | 241 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM4 | T | 138 | 4x39 | G.hns1 | R | 37 | G.hns1.02 |
Polar | TM6 | C | 241 | 6x37 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM3 | D | 121 | 3x49 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | R | 131 | 34x52 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | R | 131 | 34x52 | G.hns1 | R | 37 | G.hns1.02 |
Polar | ICL2 | T | 134 | 34x55 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | T | 134 | 34x55 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | T | 134 | 34x55 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | P | 129 | 34x50 | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | ICL2 | L | 130 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | ICL2 | R | 131 | 34x52 | G.hns1 | R | 38 | G.hns1.03 |
Van-der-waals | ICL2 | R | 131 | 34x52 | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | TM3 | A | 125 | 3x53 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | A | 125 | 3x53 | G.H5 | L | 358 | G.H5.25 |
Polar | ICL2 | L | 136 | 34x57 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | L | 136 | 34x57 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | L | 136 | 34x57 | G.hns1 | R | 37 | G.hns1.02 |
Polar | TM4 | T | 137 | 4x38 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM4 | T | 137 | 4x38 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | TM4 | T | 137 | 4x38 | G.hns1 | R | 37 | G.hns1.02 |
Polar | ICL2 | L | 130 | 34x51 | G.S1 | E | 39 | G.S1.01 |
Van-der-waals | ICL2 | L | 130 | 34x51 | G.S1 | E | 39 | G.S1.01 |
Aromatic | ICL2 | Y | 132 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | Y | 132 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | Y | 132 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM6 | A | 237 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM6 | A | 237 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | A | 237 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Polar | ICL2 | A | 133 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | A | 133 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | A | 133 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Ionic | H8 | K | 297 | 8x48 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | H8 | K | 297 | 8x48 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | H8 | E | 298 | 8x49 | G.H5 | N | 357 | G.H5.24 |
Polar | ICL2 | R | 131 | 34x52 | G.s2s3 | Q | 197 | G.s2s3.01 |
Van-der-waals | ICL2 | R | 131 | 34x52 | G.s2s3 | Q | 197 | G.s2s3.01 |
Hydrophobic | ICL2 | T | 134 | 34x55 | G.HN | D | 35 | G.HN.53 |
Van-der-waals | ICL2 | T | 134 | 34x55 | G.HN | D | 35 | G.HN.53 |
Polar | ICL2 | R | 131 | 34x52 | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 131 | 34x52 | G.s2s3 | S | 198 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 131 | 34x52 | G.s2s3 | S | 198 | G.s2s3.02 |
Polar | TM3 | A | 125 | 3x53 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM3 | A | 125 | 3x53 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM3 | A | 125 | 3x53 | G.H5 | L | 353 | G.H5.20 |
Polar | ICL2 | L | 130 | 34x51 | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | ICL2 | L | 130 | 34x51 | G.hns1 | R | 38 | G.hns1.03 |
Van-der-waals | ICL2 | L | 130 | 34x51 | G.hns1 | R | 38 | G.hns1.03 |
Polar | TM3 | R | 122 | 3x50 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM3 | R | 122 | 3x50 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM3 | R | 122 | 3x50 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL2 | P | 129 | 34x50 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | ICL2 | P | 129 | 34x50 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM3 | I | 126 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | I | 126 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | P | 129 | 34x50 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | ICL2 | P | 129 | 34x50 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | L | 130 | 34x51 | G.S3 | V | 199 | G.S3.01 |
Van-der-waals | ICL2 | L | 130 | 34x51 | G.S3 | V | 199 | G.S3.01 |
Hydrophobic | ICL2 | T | 134 | 34x55 | G.HN | R | 34 | G.HN.52 |
Van-der-waals | ICL2 | T | 134 | 34x55 | G.HN | R | 34 | G.HN.52 |
Hydrophobic | TM3 | I | 126 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM3 | I | 126 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM4 | V | 140 | 4x41 | G.HN | R | 34 | G.HN.52 |
Hydrophobic | H8 | T | 296 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | T | 296 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Polar | ICL2 | L | 130 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | ICL2 | L | 130 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Van-der-waals | ICL2 | L | 130 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Polar | TM2 | Y | 60 | 2x40 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM2 | Y | 60 | 2x40 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM5 | T | 228 | 5x68 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM5 | T | 228 | 5x68 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | ICL2 | L | 130 | 34x51 | G.S3 | F | 201 | G.S3.03 |
Van-der-waals | ICL2 | L | 130 | 34x51 | G.S3 | F | 201 | G.S3.03 |
Polar | ICL2 | Y | 132 | 34x53 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM2 | M | 59 | 2x39 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM2 | M | 59 | 2x39 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL2 | T | 134 | 34x55 | G.hns1 | A | 36 | G.hns1.01 |
Hydrophobic | TM6 | E | 233 | 6x29 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | E | 233 | 6x29 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | K | 236 | 6x32 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | TM6 | K | 236 | 6x32 | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | ICL2 | L | 130 | 34x51 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | ICL2 | L | 130 | 34x51 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM6 | N | 239 | 6x35 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | N | 239 | 6x35 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM3 | A | 125 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | A | 125 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM3 | R | 122 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 122 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 122 | 3x50 | G.H5 | Y | 356 | G.H5.23 |