Gq - OR51J1 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 71.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 24.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL1 A 57 12x49 G.hns1 R 37 G.hns1.02
Van-der-waals ICL1 A 57 12x49 G.hns1 R 37 G.hns1.02
Hydrophobic TM6 G 235 6x29 G.h4s6 I 323 G.h4s6.20
Hydrophobic H8 E 300 8x49 G.H5 Y 356 G.H5.23
Hydrophobic TM6 A 239 6x33 G.H5 K 354 G.H5.21
Polar TM6 G 235 6x29 G.H5 K 354 G.H5.21
Van-der-waals TM6 G 235 6x29 G.H5 K 354 G.H5.21
Hydrophobic TM5 I 230 5x68 G.H5 Q 350 G.H5.17
Polar TM2 Y 63 2x40 G.H5 N 357 G.H5.24
Hydrophobic TM2 Y 63 2x40 G.H5 N 357 G.H5.24
Van-der-waals TM2 Y 63 2x40 G.H5 N 357 G.H5.24
Hydrophobic TM2 M 62 2x39 G.H5 N 357 G.H5.24
Van-der-waals TM2 M 62 2x39 G.H5 N 357 G.H5.24
Hydrophobic TM2 P 61 2x38 G.H5 L 358 G.H5.25
Hydrophobic TM2 M 62 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 M 62 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM3 P 125 3x50 G.H5 V 359 G.H5.26
Van-der-waals TM3 P 125 3x50 G.H5 V 359 G.H5.26
Polar ICL1 H 59 12x51 G.HN R 34 G.HN.52
Van-der-waals ICL1 H 59 12x51 G.HN R 34 G.HN.52
Polar TM3 H 129 3x54 G.H5 Q 350 G.H5.17
Hydrophobic TM3 H 129 3x54 G.H5 Q 350 G.H5.17
Van-der-waals TM3 H 129 3x54 G.H5 Q 350 G.H5.17
Hydrophobic TM6 T 242 6x36 G.H5 V 359 G.H5.26
Van-der-waals TM6 T 242 6x36 G.H5 V 359 G.H5.26
Hydrophobic H8 T 298 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 T 298 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM2 M 62 2x39 G.H5 L 358 G.H5.25
Van-der-waals TM2 M 62 2x39 G.H5 L 358 G.H5.25
Hydrophobic H8 E 300 8x49 G.H5 E 355 G.H5.22
Van-der-waals H8 E 300 8x49 G.H5 E 355 G.H5.22
Hydrophobic ICL1 I 56 12x48 G.HN R 34 G.HN.52
Hydrophobic TM6 T 232 6x26 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM6 T 232 6x26 G.h4s6 I 323 G.h4s6.20
Polar H8 K 299 8x48 G.H5 N 357 G.H5.24
Van-der-waals H8 K 299 8x48 G.H5 N 357 G.H5.24
Polar TM2 Y 63 2x40 G.H5 Y 356 G.H5.23
Hydrophobic TM2 Y 63 2x40 G.H5 Y 356 G.H5.23
Van-der-waals TM2 Y 63 2x40 G.H5 Y 356 G.H5.23
Ionic TM3 H 129 3x54 G.H5 D 346 G.H5.13
Polar TM3 H 129 3x54 G.H5 D 346 G.H5.13
Hydrophobic TM3 H 129 3x54 G.H5 D 346 G.H5.13
Polar H8 E 300 8x49 G.H5 N 357 G.H5.24
Hydrophobic H8 E 300 8x49 G.H5 N 357 G.H5.24
Van-der-waals H8 E 300 8x49 G.H5 N 357 G.H5.24
Polar TM2 Q 60 2x37 G.H5 Y 356 G.H5.23
Hydrophobic TM2 Q 60 2x37 G.H5 Y 356 G.H5.23
Van-der-waals TM2 Q 60 2x37 G.H5 Y 356 G.H5.23
Polar ICL1 I 56 12x48 G.hns1 R 37 G.hns1.02
Hydrophobic ICL1 I 56 12x48 G.hns1 R 37 G.hns1.02
Van-der-waals ICL1 I 56 12x48 G.hns1 R 37 G.hns1.02