G15 - OR51L1 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 83.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar H8 K 299 8x48 G.H5 L 374 G.H5.26
Hydrophobic H8 K 299 8x48 G.H5 L 374 G.H5.26
Van-der-waals H8 K 299 8x48 G.H5 L 374 G.H5.26
Hydrophobic TM6 S 245 6x39 G.H5 L 373 G.H5.25
Van-der-waals TM6 S 245 6x39 G.H5 L 373 G.H5.25
Hydrophobic ICL2 L 132 34x51 G.S1 L 43 G.S1.02
Van-der-waals ICL2 L 132 34x51 G.S1 L 43 G.S1.02
Hydrophobic ICL2 L 132 34x51 G.H5 R 360 G.H5.12
Hydrophobic ICL2 P 131 34x50 G.H5 V 363 G.H5.15
Polar H8 R 302 8x51 G.H5 L 374 G.H5.26
Hydrophobic H8 R 302 8x51 G.H5 L 374 G.H5.26
Van-der-waals H8 R 302 8x51 G.H5 L 374 G.H5.26
Hydrophobic TM3 R 124 3x50 G.H5 I 371 G.H5.23
Van-der-waals TM3 R 124 3x50 G.H5 I 371 G.H5.23
Polar ICL2 H 133 34x52 G.s2s3 Q 200 G.s2s3.01
Hydrophobic ICL2 H 133 34x52 G.s2s3 Q 200 G.s2s3.01
Van-der-waals ICL2 H 133 34x52 G.s2s3 Q 200 G.s2s3.01
Polar ICL2 H 133 34x52 G.s2s3 K 201 G.s2s3.02
Hydrophobic ICL2 H 133 34x52 G.s2s3 K 201 G.s2s3.02
Van-der-waals ICL2 H 133 34x52 G.s2s3 K 201 G.s2s3.02
Polar TM3 R 124 3x50 G.H5 Y 367 G.H5.19
Van-der-waals TM3 R 124 3x50 G.H5 Y 367 G.H5.19
Hydrophobic TM2 M 61 2x39 G.H5 L 373 G.H5.25
Van-der-waals TM2 M 61 2x39 G.H5 L 373 G.H5.25
Polar TM7 R 297 7x56 G.H5 L 374 G.H5.26
Hydrophobic TM7 R 297 7x56 G.H5 L 374 G.H5.26
Van-der-waals TM7 R 297 7x56 G.H5 L 374 G.H5.26
Hydrophobic H8 T 298 8x47 G.H5 L 373 G.H5.25
Van-der-waals H8 T 298 8x47 G.H5 L 373 G.H5.25
Hydrophobic TM6 K 238 6x32 G.H5 L 368 G.H5.20
Hydrophobic ICL2 P 135 34x54 G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 P 135 34x54 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 T 136 34x55 G.hns1 G 41 G.hns1.03
Van-der-waals ICL2 T 136 34x55 G.hns1 G 41 G.hns1.03
Polar TM6 T 242 6x36 G.H5 N 372 G.H5.24
Hydrophobic TM6 T 242 6x36 G.H5 N 372 G.H5.24
Van-der-waals TM6 T 242 6x36 G.H5 N 372 G.H5.24
Hydrophobic TM3 A 127 3x53 G.H5 L 364 G.H5.16
Hydrophobic TM7 R 297 7x56 G.H5 L 373 G.H5.25
Van-der-waals TM7 R 297 7x56 G.H5 L 373 G.H5.25
Hydrophobic TM3 A 127 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 A 127 3x53 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 P 131 34x50 G.H5 L 364 G.H5.16
Hydrophobic TM3 I 128 3x54 G.H5 L 368 G.H5.20
Hydrophobic TM6 A 239 6x33 G.H5 L 368 G.H5.20
Van-der-waals TM6 A 239 6x33 G.H5 L 368 G.H5.20
Hydrophobic ICL2 L 132 34x51 G.H5 F 356 G.H5.08
Van-der-waals ICL2 L 132 34x51 G.H5 F 356 G.H5.08
Hydrophobic TM6 T 242 6x36 G.H5 L 373 G.H5.25
Van-der-waals TM6 T 242 6x36 G.H5 L 373 G.H5.25
Hydrophobic ICL2 L 132 34x51 G.S3 T 202 G.S3.01
Hydrophobic TM5 I 230 5x68 G.H5 L 364 G.H5.16
Van-der-waals TM5 I 230 5x68 G.H5 L 364 G.H5.16
Ionic TM6 E 235 6x29 G.h4s6 R 338 G.h4s6.20
Polar TM6 E 235 6x29 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM6 E 235 6x29 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM6 E 235 6x29 G.h4s6 R 338 G.h4s6.20
Ionic TM6 K 238 6x32 G.H5 D 369 G.H5.21
Polar TM6 K 238 6x32 G.H5 D 369 G.H5.21
Hydrophobic TM6 K 238 6x32 G.H5 D 369 G.H5.21
Van-der-waals TM6 K 238 6x32 G.H5 D 369 G.H5.21
Hydrophobic TM7 Y 294 7x53 G.H5 L 373 G.H5.25
Hydrophobic ICL2 P 131 34x50 G.H5 R 360 G.H5.12
Van-der-waals ICL2 P 131 34x50 G.H5 R 360 G.H5.12
Hydrophobic TM3 I 128 3x54 G.H5 L 364 G.H5.16
Van-der-waals TM3 I 128 3x54 G.H5 L 364 G.H5.16
Hydrophobic ICL2 L 132 34x51 G.H5 V 363 G.H5.15
Van-der-waals ICL2 L 132 34x51 G.H5 V 363 G.H5.15
Polar TM3 D 123 3x49 G.H5 Y 367 G.H5.19
Van-der-waals TM3 D 123 3x49 G.H5 Y 367 G.H5.19
Hydrophobic TM2 M 61 2x39 G.H5 I 371 G.H5.23
Van-der-waals TM2 M 61 2x39 G.H5 I 371 G.H5.23
Van-der-waals TM2 Q 59 2x37 G.H5 I 371 G.H5.23
Polar H8 Q 300 8x49 G.H5 E 370 G.H5.22
Hydrophobic H8 Q 300 8x49 G.H5 E 370 G.H5.22
Van-der-waals H8 Q 300 8x49 G.H5 E 370 G.H5.22
Polar H8 K 299 8x48 G.H5 N 372 G.H5.24
Hydrophobic TM6 K 238 6x32 G.H5 N 372 G.H5.24
Van-der-waals TM6 K 238 6x32 G.H5 N 372 G.H5.24
Polar ICL2 H 133 34x52 G.S3 T 202 G.S3.01
Hydrophobic ICL2 H 133 34x52 G.S3 T 202 G.S3.01
Van-der-waals ICL2 H 133 34x52 G.S3 T 202 G.S3.01
Hydrophobic TM6 T 242 6x36 G.H5 L 368 G.H5.20
Polar TM2 Q 59 2x37 G.H5 E 370 G.H5.22
Van-der-waals TM2 Q 59 2x37 G.H5 E 370 G.H5.22
Polar ICL2 Y 134 34x53 G.H5 Y 367 G.H5.19
Aromatic ICL2 Y 134 34x53 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 Y 134 34x53 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 Y 134 34x53 G.H5 Y 367 G.H5.19
Polar TM6 N 241 6x35 G.H5 L 373 G.H5.25
Hydrophobic TM6 T 242 6x36 G.H5 I 371 G.H5.23
Van-der-waals TM6 T 242 6x36 G.H5 I 371 G.H5.23
Hydrophobic ICL2 L 132 34x51 G.H5 V 359 G.H5.11