G13 - OR51Q1 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 80.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 C 130 3x56 G.hns1 K 46 G.hns1.02
Van-der-waals TM3 C 130 3x56 G.hns1 K 46 G.hns1.02
Polar ICL2 A 135 34x54 G.H5 Q 373 G.H5.22
Hydrophobic ICL2 A 135 34x54 G.H5 Q 373 G.H5.22
Hydrophobic TM2 M 61 2x39 G.H5 Q 377 G.H5.26
Van-der-waals TM2 M 61 2x39 G.H5 Q 377 G.H5.26
Hydrophobic TM2 M 61 2x39 G.H5 M 375 G.H5.24
Polar ICL2 P 131 34x50 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 A 135 34x54 G.h3s5 N 283 G.h3s5.02
Polar TM2 Q 59 2x37 G.H5 Q 373 G.H5.22
Hydrophobic TM2 Q 59 2x37 G.H5 Q 373 G.H5.22
Polar TM5 T 230 5x68 G.s2s3 N 215 G.s2s3.02
Hydrophobic TM5 T 230 5x68 G.s2s3 N 215 G.s2s3.02
Van-der-waals TM5 T 230 5x68 G.s2s3 N 215 G.s2s3.02
Polar H8 N 298 8x47 G.H5 L 376 G.H5.25
Hydrophobic H8 N 298 8x47 G.H5 L 376 G.H5.25
Van-der-waals H8 N 298 8x47 G.H5 L 376 G.H5.25
Hydrophobic TM2 M 61 2x39 G.H5 L 376 G.H5.25
Van-der-waals TM2 M 61 2x39 G.H5 L 376 G.H5.25
Polar ICL2 H 133 34x52 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 H 133 34x52 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 H 133 34x52 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 P 131 34x50 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 L 132 34x51 G.S1 L 48 G.S1.01
Van-der-waals ICL2 L 132 34x51 G.S1 L 48 G.S1.01
Hydrophobic TM3 A 127 3x53 G.H5 L 374 G.H5.23
Van-der-waals TM3 A 127 3x53 G.H5 L 374 G.H5.23
Hydrophobic TM3 C 129 3x55 G.hns1 K 46 G.hns1.02
Polar ICL2 Y 134 34x53 G.H5 Q 373 G.H5.22
Hydrophobic ICL2 Y 134 34x53 G.H5 Q 373 G.H5.22
Van-der-waals ICL2 Y 134 34x53 G.H5 Q 373 G.H5.22
Hydrophobic ICL2 P 131 34x50 G.H5 L 374 G.H5.23
Hydrophobic ICL1 H 58 12x51 G.h4s6 Q 339 G.h4s6.13
Van-der-waals TM5 I 227 5x65 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 L 132 34x51 G.S1 V 49 G.S1.02
Van-der-waals ICL2 L 132 34x51 G.S1 V 49 G.S1.02
Hydrophobic ICL2 P 131 34x50 G.H5 N 370 G.H5.19
Van-der-waals ICL2 P 131 34x50 G.H5 N 370 G.H5.19
Polar TM6 S 245 6x39 G.H5 Q 377 G.H5.26
Hydrophobic TM6 S 245 6x39 G.H5 Q 377 G.H5.26
Van-der-waals TM6 S 245 6x39 G.H5 Q 377 G.H5.26
Hydrophobic TM2 Q 59 2x37 G.H5 K 372 G.H5.21
Van-der-waals TM2 Q 59 2x37 G.H5 K 372 G.H5.21
Polar TM7 K 297 7x56 G.H5 Q 377 G.H5.26
Hydrophobic TM7 K 297 7x56 G.H5 Q 377 G.H5.26
Van-der-waals TM7 K 297 7x56 G.H5 Q 377 G.H5.26
Hydrophobic ICL2 L 132 34x51 G.H5 N 370 G.H5.19
Van-der-waals ICL2 L 132 34x51 G.H5 N 370 G.H5.19
Polar TM3 C 129 3x55 G.hns1 R 47 G.hns1.03
Hydrophobic TM3 C 129 3x55 G.hns1 R 47 G.hns1.03
Van-der-waals TM3 C 129 3x55 G.hns1 R 47 G.hns1.03
Hydrophobic TM3 I 128 3x54 G.H5 L 374 G.H5.23
Van-der-waals TM3 I 128 3x54 G.H5 L 374 G.H5.23
Polar TM5 N 226 5x64 G.hns1 R 47 G.hns1.03
Hydrophobic TM5 N 226 5x64 G.hns1 R 47 G.hns1.03
Van-der-waals TM5 N 226 5x64 G.hns1 R 47 G.hns1.03
Hydrophobic TM5 N 226 5x64 G.HN T 43 G.HN.52
Van-der-waals TM5 N 226 5x64 G.HN T 43 G.HN.52
Polar TM5 T 230 5x68 G.hns1 R 47 G.hns1.03
Hydrophobic TM5 T 230 5x68 G.hns1 R 47 G.hns1.03
Van-der-waals TM5 T 230 5x68 G.hns1 R 47 G.hns1.03
Hydrophobic TM3 C 130 3x56 G.hns1 R 47 G.hns1.03
Hydrophobic TM6 T 232 6x26 G.s2s3 N 215 G.s2s3.02
Hydrophobic TM2 Y 62 2x40 G.H5 L 376 G.H5.25
Van-der-waals TM2 Y 62 2x40 G.H5 L 376 G.H5.25
Hydrophobic ICL3 A 231 - G.s2s3 N 215 G.s2s3.02
Hydrophobic TM6 N 242 6x36 G.H5 L 371 G.H5.20
Van-der-waals TM6 N 242 6x36 G.H5 L 371 G.H5.20
Hydrophobic TM2 Q 59 2x37 G.H5 L 376 G.H5.25
Van-der-waals TM2 Q 59 2x37 G.H5 L 376 G.H5.25
Hydrophobic TM6 N 242 6x36 G.H5 M 375 G.H5.24
Van-der-waals TM6 N 242 6x36 G.H5 M 375 G.H5.24
Polar TM7 Y 294 7x53 G.H5 Q 377 G.H5.26
Hydrophobic TM7 Y 294 7x53 G.H5 Q 377 G.H5.26
Van-der-waals TM7 Y 294 7x53 G.H5 Q 377 G.H5.26
Hydrophobic TM3 M 120 3x46 G.H5 Q 377 G.H5.26
Van-der-waals TM3 M 120 3x46 G.H5 Q 377 G.H5.26
Polar ICL2 H 133 34x52 G.h2s4 S 239 G.h2s4.03
Hydrophobic ICL2 H 133 34x52 G.h2s4 S 239 G.h2s4.03
Van-der-waals ICL2 H 133 34x52 G.h2s4 S 239 G.h2s4.03
Hydrophobic ICL2 L 132 34x51 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 L 132 34x51 G.hns1 R 47 G.hns1.03
Hydrophobic TM6 E 235 6x29 G.s2s3 K 214 G.s2s3.01
Van-der-waals TM6 E 235 6x29 G.s2s3 K 214 G.s2s3.01
Hydrophobic ICL2 I 137 34x56 G.hns1 K 46 G.hns1.02
Hydrophobic ICL1 P 55 12x48 G.h4s6 Q 339 G.h4s6.13
Van-der-waals ICL1 P 55 12x48 G.h4s6 Q 339 G.h4s6.13
Polar TM2 R 60 2x38 G.h3s5 N 283 G.h3s5.02
Polar TM6 H 246 6x40 G.H5 Q 377 G.H5.26
Van-der-waals TM6 H 246 6x40 G.H5 Q 377 G.H5.26
Hydrophobic TM2 M 61 2x39 G.H5 L 374 G.H5.23
Van-der-waals TM2 M 61 2x39 G.H5 L 374 G.H5.23
Polar ICL2 L 132 34x51 G.h2s4 T 241 G.h2s4.05
Hydrophobic ICL2 L 132 34x51 G.h2s4 T 241 G.h2s4.05
Van-der-waals ICL2 L 132 34x51 G.h2s4 T 241 G.h2s4.05
Polar ICL2 H 133 34x52 G.hns1 V 45 G.hns1.01
Hydrophobic ICL2 H 133 34x52 G.hns1 V 45 G.hns1.01
Van-der-waals ICL2 H 133 34x52 G.hns1 V 45 G.hns1.01