Gt2 - OR51Q1 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 84.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 18.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 R 238 6x32 G.H5 K 345 G.H5.17
Hydrophobic TM7 Y 294 7x53 G.H5 L 353 G.H5.25
Van-der-waals TM7 Y 294 7x53 G.H5 L 353 G.H5.25
Polar ICL2 Y 134 34x53 G.H5 D 350 G.H5.22
Hydrophobic ICL2 Y 134 34x53 G.H5 D 350 G.H5.22
Van-der-waals ICL2 Y 134 34x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 A 127 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 127 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL1 S 56 12x49 G.h4s6 V 316 G.h4s6.10
Van-der-waals ICL1 S 56 12x49 G.h4s6 V 316 G.h4s6.10
Hydrophobic TM2 M 61 2x39 G.H5 G 352 G.H5.24
Van-der-waals TM2 M 61 2x39 G.H5 G 352 G.H5.24
Hydrophobic ICL2 L 132 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 132 34x51 G.H5 I 343 G.H5.15
Polar TM6 N 242 6x36 G.H5 L 348 G.H5.20
Van-der-waals TM6 N 242 6x36 G.H5 L 348 G.H5.20
Polar TM7 K 297 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM7 K 297 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 K 297 7x56 G.H5 L 353 G.H5.25
Polar ICL2 H 133 34x52 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 H 133 34x52 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 H 133 34x52 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 P 131 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 132 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 132 34x51 G.S3 L 194 G.S3.01
Polar TM3 C 124 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 C 124 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 C 124 3x50 G.H5 C 351 G.H5.23
Polar TM3 A 127 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 A 127 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 127 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 132 34x51 G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL2 I 137 34x56 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 I 137 34x56 G.hns1 A 31 G.hns1.02
Hydrophobic TM2 M 61 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 M 61 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 H 246 6x40 G.H5 L 353 G.H5.25
Van-der-waals TM6 H 246 6x40 G.H5 L 353 G.H5.25
Hydrophobic TM3 C 130 3x56 G.hns1 K 32 G.hns1.03
Polar TM2 M 61 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 M 61 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 M 61 2x39 G.H5 D 350 G.H5.22
Polar ICL2 P 131 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 131 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 131 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 128 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 128 3x54 G.H5 L 348 G.H5.20
Polar H8 N 298 8x47 G.H5 F 354 G.H5.26
Hydrophobic H8 N 298 8x47 G.H5 F 354 G.H5.26
Polar TM3 D 123 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 D 123 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 D 123 3x49 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 132 34x51 G.S1 V 34 G.S1.02
Van-der-waals ICL2 L 132 34x51 G.S1 V 34 G.S1.02
Polar ICL2 H 133 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 H 133 34x52 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 H 133 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 S 245 6x39 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 245 6x39 G.H5 L 353 G.H5.25
Polar TM3 A 127 3x53 G.H5 L 348 G.H5.20
Hydrophobic TM3 A 127 3x53 G.H5 L 348 G.H5.20
Van-der-waals TM3 A 127 3x53 G.H5 L 348 G.H5.20
Hydrophobic TM6 C 243 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 C 243 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 244 6x38 G.H5 L 353 G.H5.25
Aromatic TM7 K 297 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 238 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 238 6x32 G.H5 F 354 G.H5.26
Polar ICL2 Y 134 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 134 34x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 Y 134 34x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 N 242 6x36 G.H5 F 354 G.H5.26
Van-der-waals TM6 N 242 6x36 G.H5 F 354 G.H5.26
Polar TM2 Q 59 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 Q 59 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 Q 59 2x37 G.H5 D 350 G.H5.22
Polar TM6 N 242 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 N 242 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 N 242 6x36 G.H5 L 353 G.H5.25
Polar ICL2 H 133 34x52 G.hns1 E 30 G.hns1.01
Hydrophobic ICL2 H 133 34x52 G.hns1 E 30 G.hns1.01
Van-der-waals ICL2 H 133 34x52 G.hns1 E 30 G.hns1.01
Polar ICL2 H 133 34x52 G.S1 V 34 G.S1.02
Polar ICL2 H 133 34x52 G.S1 T 33 G.S1.01
Hydrophobic ICL2 H 133 34x52 G.S1 T 33 G.S1.01
Van-der-waals ICL2 H 133 34x52 G.S1 T 33 G.S1.01
Hydrophobic ICL2 L 132 34x51 G.H5 N 347 G.H5.19
Van-der-waals ICL2 L 132 34x51 G.H5 N 347 G.H5.19