Ggust - OR51S1 complex model

GPCR CLASS (FAMILY)

O1 (fish-like odorant)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 M 67 2x39 G.H5 L 353 G.H5.25
Hydrophobic TM2 M 67 2x39 G.H5 G 352 G.H5.24
Van-der-waals TM2 M 67 2x39 G.H5 G 352 G.H5.24
Hydrophobic TM3 A 133 3x53 G.H5 C 351 G.H5.23
Polar ICL2 H 139 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 H 139 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 H 139 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 A 142 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 A 142 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic H8 M 303 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 M 303 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 137 34x50 G.H5 L 348 G.H5.20
Van-der-waals ICL2 P 137 34x50 G.H5 L 348 G.H5.20
Polar TM2 R 65 2x37 G.H5 K 349 G.H5.21
Hydrophobic TM6 A 244 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 244 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 243 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 243 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 130 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 130 3x50 G.H5 L 353 G.H5.25
Ionic H8 K 308 8x52 G.h4s6 D 316 G.h4s6.10
Polar H8 K 308 8x52 G.h4s6 D 316 G.h4s6.10
Van-der-waals H8 K 308 8x52 G.h4s6 D 316 G.h4s6.10
Hydrophobic TM3 A 133 3x53 G.H5 L 348 G.H5.20
Van-der-waals TM3 A 133 3x53 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 138 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 137 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 137 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 A 133 3x53 G.H5 L 353 G.H5.25
Van-der-waals TM3 A 133 3x53 G.H5 L 353 G.H5.25
Polar ICL2 Y 140 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 140 34x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 Y 140 34x53 G.H5 C 351 G.H5.23
Polar ICL2 A 142 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 A 142 34x55 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 A 142 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 L 138 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 138 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM2 M 67 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 M 67 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 141 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 P 141 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 L 138 34x51 G.H5 I 344 G.H5.16
Van-der-waals ICL2 L 138 34x51 G.H5 I 344 G.H5.16
Hydrophobic TM3 I 134 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 D 129 3x49 G.H5 L 353 G.H5.25
Ionic TM2 R 65 2x37 G.H5 D 350 G.H5.22
Polar TM2 R 65 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 R 65 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 65 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL2 A 142 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 A 142 34x55 G.HN E 28 G.HN.52
Hydrophobic ICL2 Y 140 34x53 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 138 34x51 G.S1 V 34 G.S1.02
Ionic TM6 D 240 6x29 G.H5 K 345 G.H5.17
Polar TM6 D 240 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 D 240 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 D 240 6x29 G.H5 K 345 G.H5.17
Ionic H8 K 308 8x52 G.h4s6 E 315 G.h4s6.09
Hydrophobic ICL2 H 139 34x52 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 139 34x52 G.hns1 R 32 G.hns1.03
Polar TM6 T 247 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 247 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 247 6x36 G.H5 L 353 G.H5.25
Polar TM6 T 247 6x36 G.H5 F 354 G.H5.26