GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 72.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | S | 411 | - | G.S2 | C | 196 | G.S2.05 |
Polar | H8 | H | 354 | 8x47 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | H8 | H | 354 | 8x47 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | C-term | R | 408 | - | G.S3 | R | 205 | G.S3.04 |
Van-der-waals | C-term | R | 408 | - | G.S3 | R | 205 | G.S3.04 |
Hydrophobic | ICL2 | F | 179 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | F | 179 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Polar | C-term | L | 412 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | L | 412 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | M | 423 | - | G.S2 | N | 193 | G.S2.02 |
Polar | TM3 | R | 168 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | R | 168 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM6 | I | 297 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | I | 297 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM3 | I | 172 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | L | 176 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.H5 | V | 359 | G.H5.11 |
Polar | C-term | Q | 409 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | Q | 409 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | C-term | R | 408 | - | G.S2 | E | 194 | G.S2.03 |
Polar | C-term | R | 377 | - | G.h4s6 | K | 332 | G.h4s6.14 |
Van-der-waals | C-term | R | 377 | - | G.h4s6 | K | 332 | G.h4s6.14 |
Hydrophobic | ICL2 | F | 179 | 34x54 | G.h2s4 | I | 227 | G.h2s4.05 |
Van-der-waals | ICL2 | F | 179 | 34x54 | G.h2s4 | I | 227 | G.h2s4.05 |
Ionic | C-term | R | 408 | - | G.S1 | E | 42 | G.S1.01 |
Polar | C-term | R | 408 | - | G.S1 | E | 42 | G.S1.01 |
Van-der-waals | C-term | R | 408 | - | G.S1 | E | 42 | G.S1.01 |
Hydrophobic | C-term | T | 421 | - | H.HA | E | 74 | H.HA.03 |
Hydrophobic | C-term | E | 424 | - | H.HA | F | 78 | H.HA.07 |
Van-der-waals | C-term | E | 424 | - | H.HA | F | 78 | H.HA.07 |
Hydrophobic | C-term | L | 412 | - | G.S2 | F | 197 | G.S2.06 |
Van-der-waals | C-term | L | 412 | - | G.S2 | F | 197 | G.S2.06 |
Hydrophobic | ICL2 | P | 175 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | P | 175 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Polar | C-term | Y | 385 | - | G.h3s5 | T | 270 | G.h3s5.03 |
Polar | C-term | Y | 385 | - | G.h3s5 | S | 269 | G.h3s5.02 |
Hydrophobic | C-term | Y | 385 | - | G.h3s5 | S | 269 | G.h3s5.02 |
Van-der-waals | C-term | Y | 385 | - | G.h3s5 | S | 269 | G.h3s5.02 |
Hydrophobic | TM5 | F | 272 | 5x75 | G.S6 | H | 342 | G.S6.04 |
Van-der-waals | TM5 | F | 272 | 5x75 | G.S6 | H | 342 | G.S6.04 |
Van-der-waals | C-term | W | 420 | - | H.HA | E | 74 | H.HA.03 |
Hydrophobic | TM5 | I | 262 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM5 | I | 262 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Ionic | H8 | K | 356 | 8x49 | G.H5 | E | 370 | G.H5.22 |
Polar | H8 | K | 356 | 8x49 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | H8 | K | 356 | 8x49 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | H8 | K | 356 | 8x49 | G.H5 | E | 370 | G.H5.22 |
Polar | C-term | E | 424 | - | G.h1ha | Y | 70 | G.h1ha.04 |
Hydrophobic | TM3 | R | 168 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | R | 168 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Aromatic | C-term | W | 420 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | C-term | W | 420 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | W | 420 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | TM3 | V | 171 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | V | 171 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | E | 424 | - | G.hfs2 | M | 187 | G.hfs2.03 |
Hydrophobic | TM5 | L | 269 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | L | 269 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Ionic | C-term | R | 408 | - | G.hns1 | D | 39 | G.hns1.01 |
Hydrophobic | ICL2 | P | 175 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | C-term | A | 427 | - | G.hfs2 | M | 187 | G.hfs2.03 |
Van-der-waals | C-term | A | 427 | - | G.hfs2 | M | 187 | G.hfs2.03 |
Polar | TM7 | T | 353 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | T | 353 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Polar | C-term | H | 378 | - | G.h4s6 | K | 332 | G.h4s6.14 |
Aromatic | C-term | H | 378 | - | G.h4s6 | K | 332 | G.h4s6.14 |
Hydrophobic | C-term | H | 378 | - | G.h4s6 | K | 332 | G.h4s6.14 |
Van-der-waals | C-term | H | 378 | - | G.h4s6 | K | 332 | G.h4s6.14 |
Aromatic | C-term | W | 420 | - | G.S2 | Y | 195 | G.S2.04 |
Hydrophobic | C-term | W | 420 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | W | 420 | - | G.S2 | Y | 195 | G.S2.04 |
Polar | C-term | R | 408 | - | G.HN | Q | 38 | G.HN.53 |
Van-der-waals | C-term | R | 408 | - | G.HN | Q | 38 | G.HN.53 |
Ionic | C-term | H | 389 | - | G.h2s4 | E | 224 | G.h2s4.02 |
Polar | C-term | H | 389 | - | G.h2s4 | E | 224 | G.h2s4.02 |
Hydrophobic | C-term | H | 389 | - | G.h2s4 | E | 224 | G.h2s4.02 |
Van-der-waals | C-term | H | 389 | - | G.h2s4 | E | 224 | G.h2s4.02 |
Hydrophobic | ICL2 | P | 175 | 34x50 | G.H5 | L | 364 | G.H5.16 |
Ionic | C-term | E | 424 | - | G.H1 | K | 60 | G.H1.06 |
Polar | C-term | E | 424 | - | G.H1 | K | 60 | G.H1.06 |
Hydrophobic | C-term | E | 424 | - | G.H1 | K | 60 | G.H1.06 |
Van-der-waals | C-term | E | 424 | - | G.H1 | K | 60 | G.H1.06 |
Hydrophobic | TM3 | I | 172 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM5 | F | 272 | 5x75 | G.S6 | F | 340 | G.S6.02 |
Polar | TM6 | K | 293 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | K | 293 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | K | 293 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM5 | T | 265 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM6 | Q | 286 | 6x25 | G.H5 | L | 374 | G.H5.26 |
Ionic | C-term | R | 406 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | C-term | L | 412 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | ICL2 | G | 180 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | C-term | V | 428 | - | H.HA | Q | 84 | H.HA.13 |
Hydrophobic | C-term | L | 412 | - | G.h1ha | G | 67 | G.h1ha.01 |
Hydrophobic | TM5 | K | 276 | 5x79 | G.H4 | T | 317 | G.H4.16 |
Van-der-waals | TM5 | K | 276 | 5x79 | G.H4 | T | 317 | G.H4.16 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | L | 176 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | Q | 409 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | Q | 409 | - | G.S2 | Y | 195 | G.S2.04 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM5 | T | 265 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | T | 265 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Polar | C-term | Q | 409 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | H8 | P | 355 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | P | 355 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | E | 410 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | TM3 | I | 172 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | ICL2 | L | 176 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | L | 176 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | TM6 | S | 290 | 6x29 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | S | 290 | 6x29 | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | H | 389 | - | G.HN | K | 36 | G.HN.51 |
Van-der-waals | C-term | H | 389 | - | G.HN | K | 36 | G.HN.51 |
Hydrophobic | TM5 | I | 262 | 5x65 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM5 | L | 269 | 5x72 | G.S6 | F | 340 | G.S6.02 |
Hydrophobic | C-term | L | 412 | - | G.h1ha | A | 68 | G.h1ha.02 |
Hydrophobic | ICL2 | F | 179 | 34x54 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | F | 179 | 34x54 | G.S1 | L | 43 | G.S1.02 |
Aromatic | C-term | Y | 385 | - | G.H5 | R | 366 | G.H5.18 |
Hydrophobic | C-term | V | 428 | - | G.hfs2 | M | 187 | G.hfs2.03 |
Polar | TM6 | K | 293 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Polar | ICL2 | G | 180 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | G | 180 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | G | 180 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM5 | A | 268 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | TM6 | M | 294 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | M | 294 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL2 | F | 179 | 34x54 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM5 | F | 272 | 5x75 | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | TM5 | F | 272 | 5x75 | G.H5 | K | 357 | G.H5.09 |
Polar | C-term | R | 406 | - | G.H2 | H | 221 | G.H2.09 |
Van-der-waals | C-term | R | 406 | - | G.H2 | H | 221 | G.H2.09 |