G15 - OPN5 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 138 34x50 G.H5 F 356 G.H5.08
Hydrophobic TM3 K 134 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 K 134 3x53 G.H5 Y 367 G.H5.19
Polar TM5 E 232 5x71 G.H5 K 357 G.H5.09
Hydrophobic TM5 E 232 5x71 G.H5 K 357 G.H5.09
Van-der-waals TM5 E 232 5x71 G.H5 K 357 G.H5.09
Hydrophobic TM2 A 68 2x39 G.H5 I 371 G.H5.23
Polar H8 C 316 8x53 G.h4s6 K 332 G.h4s6.14
Hydrophobic H8 C 316 8x53 G.h4s6 K 332 G.h4s6.14
Van-der-waals H8 C 316 8x53 G.h4s6 K 332 G.h4s6.14
Hydrophobic TM6 L 250 6x33 G.H5 I 371 G.H5.23
Polar TM5 S 229 5x68 G.H5 R 360 G.H5.12
Hydrophobic TM5 S 229 5x68 G.H5 R 360 G.H5.12
Van-der-waals TM5 S 229 5x68 G.H5 R 360 G.H5.12
Polar TM4 K 145 4x38 G.HN K 36 G.HN.51
Hydrophobic TM3 I 135 3x54 G.H5 L 364 G.H5.16
Van-der-waals TM3 I 135 3x54 G.H5 L 364 G.H5.16
Hydrophobic ICL2 L 138 34x50 G.H5 R 360 G.H5.12
Van-der-waals ICL2 L 138 34x50 G.H5 R 360 G.H5.12
Hydrophobic C-term R 341 - G.HN Q 35 G.HN.50
Van-der-waals C-term R 341 - G.HN Q 35 G.HN.50
Polar H8 D 310 8x47 G.H5 N 372 G.H5.24
Hydrophobic H8 D 310 8x47 G.H5 N 372 G.H5.24
Van-der-waals H8 D 310 8x47 G.H5 N 372 G.H5.24
Polar C-term V 340 - G.S2 I 192 G.S2.01
Hydrophobic C-term T 339 - G.S2 I 192 G.S2.01
Hydrophobic TM4 K 145 4x38 G.hns1 R 40 G.hns1.02
Van-der-waals TM4 K 145 4x38 G.hns1 R 40 G.hns1.02
Hydrophobic TM6 L 250 6x33 G.H5 L 373 G.H5.25
Van-der-waals TM6 L 250 6x33 G.H5 L 373 G.H5.25
Hydrophobic TM6 L 246 6x29 G.H5 L 368 G.H5.20
Van-der-waals TM6 L 246 6x29 G.H5 L 368 G.H5.20
Hydrophobic C-term L 329 - G.H3 P 265 G.H3.16
Hydrophobic TM5 K 225 5x64 G.H5 R 360 G.H5.12
Van-der-waals ICL3 F 236 - G.H5 K 357 G.H5.09
Hydrophobic TM7 I 309 7x56 G.H5 N 372 G.H5.24
Van-der-waals TM7 I 309 7x56 G.H5 N 372 G.H5.24
Hydrophobic TM3 R 131 3x50 G.H5 I 371 G.H5.23
Hydrophobic TM5 V 233 5x72 G.H5 K 357 G.H5.09
Polar ICL2 S 139 34x51 G.s2s3 K 201 G.s2s3.02
Hydrophobic ICL1 R 66 12x51 G.H5 E 370 G.H5.22
Van-der-waals ICL1 R 66 12x51 G.H5 E 370 G.H5.22
Polar ICL2 G 141 34x53 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 G 141 34x53 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 G 141 34x53 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 V 142 34x54 G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 V 142 34x54 G.hns1 R 40 G.hns1.02
Hydrophobic C-term V 337 - G.S2 I 192 G.S2.01
Ionic C-term R 341 - G.S2 E 194 G.S2.03
Polar C-term R 341 - G.S2 E 194 G.S2.03
Hydrophobic C-term R 341 - G.S2 E 194 G.S2.03
Van-der-waals C-term R 341 - G.S2 E 194 G.S2.03
Polar ICL2 W 143 34x55 G.hns1 R 40 G.hns1.02
Aromatic ICL2 W 143 34x55 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 W 143 34x55 G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 W 143 34x55 G.hns1 R 40 G.hns1.02
Hydrophobic C-term V 337 - G.H2 H 221 G.H2.09
Polar ICL2 V 142 34x54 G.H5 Y 367 G.H5.19
Hydrophobic TM7 I 309 7x56 G.H5 I 371 G.H5.23
Van-der-waals TM7 I 309 7x56 G.H5 I 371 G.H5.23
Hydrophobic ICL2 L 138 34x50 G.S3 T 202 G.S3.01
Hydrophobic C-term K 342 - G.S2 Y 195 G.S2.04
Hydrophobic C-term T 339 - G.S2 E 194 G.S2.03
Polar C-term S 344 - G.S2 C 196 G.S2.05
Van-der-waals C-term S 344 - G.S2 C 196 G.S2.05
Hydrophobic ICL2 L 138 34x50 G.H5 V 363 G.H5.15
Van-der-waals ICL2 L 138 34x50 G.H5 V 363 G.H5.15
Hydrophobic C-term T 336 - G.H2 H 221 G.H2.09
Van-der-waals C-term V 346 - G.S2 S 198 G.S2.07
Polar C-term V 340 - G.S2 E 194 G.S2.03
Van-der-waals C-term V 340 - G.S2 E 194 G.S2.03
Polar C-term K 342 - G.S2 C 196 G.S2.05
Hydrophobic TM6 L 246 6x29 G.H5 L 373 G.H5.25
Van-der-waals TM6 L 246 6x29 G.H5 L 373 G.H5.25
Polar ICL2 S 139 34x51 G.S3 T 202 G.S3.01
Hydrophobic ICL2 L 138 34x50 G.S1 L 43 G.S1.02
Van-der-waals TM4 K 147 4x40 G.hns1 R 40 G.hns1.02
Ionic C-term R 341 - G.hns1 D 39 G.hns1.01
Polar C-term R 341 - G.hns1 D 39 G.hns1.01
Van-der-waals C-term R 341 - G.hns1 D 39 G.hns1.01
Hydrophobic TM5 V 233 5x72 G.H5 D 361 G.H5.13
Van-der-waals TM5 V 233 5x72 G.H5 D 361 G.H5.13
Hydrophobic TM6 V 253 6x36 G.H5 L 373 G.H5.25
Van-der-waals TM6 V 253 6x36 G.H5 L 373 G.H5.25
Hydrophobic C-term V 337 - G.H2 K 218 G.H2.06
Polar C-term H 335 - G.H2 H 221 G.H2.09
Hydrophobic C-term H 335 - G.H2 H 221 G.H2.09
Van-der-waals C-term H 335 - G.H2 H 221 G.H2.09
Hydrophobic ICL2 V 142 34x54 G.S1 L 43 G.S1.02
Van-der-waals ICL2 V 142 34x54 G.S1 L 43 G.S1.02
Polar C-term R 341 - G.HN Q 38 G.HN.53
Van-der-waals C-term R 341 - G.HN Q 38 G.HN.53
Hydrophobic C-term R 341 - G.S3 R 205 G.S3.04
Van-der-waals C-term R 341 - G.S3 R 205 G.S3.04
Hydrophobic C-term F 332 - G.H2 K 217 G.H2.05
Hydrophobic TM6 L 246 6x29 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM6 L 246 6x29 G.h4s6 R 338 G.h4s6.20
Hydrophobic C-term F 332 - G.H2 I 220 G.H2.08
Van-der-waals C-term F 332 - G.H2 I 220 G.H2.08
Hydrophobic TM6 L 246 6x29 G.H5 L 374 G.H5.26
Van-der-waals TM6 L 246 6x29 G.H5 L 374 G.H5.26
Aromatic H8 F 313 8x50 G.h4s6 R 335 G.h4s6.17
Hydrophobic H8 F 313 8x50 G.h4s6 R 335 G.h4s6.17
Hydrophobic C-term V 346 - G.H1 H 66 G.H1.12
Van-der-waals C-term V 346 - G.H1 H 66 G.H1.12
Hydrophobic C-term V 346 - G.h1ha G 67 G.h1ha.01
Van-der-waals C-term V 346 - G.h1ha G 67 G.h1ha.01
Polar TM5 S 229 5x68 G.H5 D 361 G.H5.13
Van-der-waals TM5 S 229 5x68 G.H5 D 361 G.H5.13
Hydrophobic ICL2 V 142 34x54 G.h2s4 I 227 G.h2s4.05
Hydrophobic C-term L 334 - G.H2 H 221 G.H2.09
Van-der-waals C-term L 334 - G.H2 H 221 G.H2.09
Ionic C-term R 341 - G.S1 E 42 G.S1.01
Hydrophobic TM3 I 135 3x54 G.H5 L 368 G.H5.20
Hydrophobic H8 F 313 8x50 G.H5 N 372 G.H5.24
Van-der-waals H8 F 313 8x50 G.H5 N 372 G.H5.24
Ionic TM5 E 232 5x71 G.H5 R 360 G.H5.12
Polar TM5 E 232 5x71 G.H5 R 360 G.H5.12
Hydrophobic TM5 E 232 5x71 G.H5 R 360 G.H5.12
Van-der-waals TM5 E 232 5x71 G.H5 R 360 G.H5.12
Hydrophobic TM6 L 250 6x33 G.H5 L 368 G.H5.20
Van-der-waals TM6 L 250 6x33 G.H5 L 368 G.H5.20
Polar C-term K 342 - G.S2 E 194 G.S2.03
Van-der-waals C-term K 342 - G.S2 E 194 G.S2.03
Hydrophobic TM7 I 309 7x56 G.H5 L 373 G.H5.25