Ggust - P2Y1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 156 34x50 G.H5 L 348 G.H5.20
Hydrophobic TM3 H 148 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 153 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 V 153 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL2 R 162 34x56 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 162 34x56 G.hns1 A 31 G.hns1.02
Polar ICL2 P 156 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 157 34x51 G.H5 I 344 G.H5.16
Van-der-waals ICL2 L 157 34x51 G.H5 I 344 G.H5.16
Hydrophobic TM2 I 86 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 I 86 2x39 G.H5 C 351 G.H5.23
Ionic H8 R 337 8x56 G.h4s6 D 316 G.h4s6.10
Polar H8 R 337 8x56 G.h4s6 D 316 G.h4s6.10
Van-der-waals H8 R 337 8x56 G.h4s6 D 316 G.h4s6.10
Hydrophobic TM6 S 258 6x34 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 258 6x34 G.H5 L 353 G.H5.25
Polar TM2 S 84 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 84 2x37 G.H5 D 350 G.H5.22
Polar ICL2 R 162 34x56 G.HN Q 24 G.HN.48
Hydrophobic TM3 G 152 3x53 G.H5 L 353 G.H5.25
Hydrophobic C-term L 359 - G.H3 H 256 G.H3.15
Van-der-waals C-term L 359 - G.H3 H 256 G.H3.15
Hydrophobic TM3 V 153 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 K 158 34x52 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 158 34x52 G.hns1 R 32 G.hns1.03
Ionic ICL2 K 158 34x52 G.HN E 28 G.HN.52
Polar ICL2 K 158 34x52 G.HN E 28 G.HN.52
Van-der-waals ICL2 K 158 34x52 G.HN E 28 G.HN.52
Hydrophobic C-term L 362 - G.H2 R 208 G.H2.04
Hydrophobic ICL1 P 82 - G.h3s5 T 261 G.h3s5.02
Van-der-waals ICL1 P 82 - G.h3s5 T 261 G.h3s5.02
Hydrophobic ICL2 L 157 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 L 157 34x51 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 K 158 34x52 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 K 158 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic C-term P 363 - G.H2 K 209 G.H2.05
Van-der-waals C-term L 359 - G.H3 S 252 G.H3.11
Hydrophobic ICL3 N 251 - G.H5 F 354 G.H5.26
Polar TM3 R 149 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 149 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 160 34x54 G.H5 N 347 G.H5.19
Van-der-waals ICL2 L 160 34x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 160 34x54 G.h2s4 T 219 G.h2s4.05
Van-der-waals ICL2 L 160 34x54 G.h2s4 T 219 G.h2s4.05
Hydrophobic TM6 L 254 6x30 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 254 6x30 G.H5 L 348 G.H5.20
Ionic ICL2 R 162 34x56 G.HN E 28 G.HN.52
Hydrophobic ICL2 R 162 34x56 G.HN E 28 G.HN.52
Van-der-waals ICL2 R 162 34x56 G.HN E 28 G.HN.52
Ionic H8 R 337 8x56 G.h4s6 E 315 G.h4s6.09
Polar H8 R 337 8x56 G.h4s6 E 315 G.h4s6.09
Hydrophobic H8 R 337 8x56 G.h4s6 E 315 G.h4s6.09
Van-der-waals H8 R 337 8x56 G.h4s6 E 315 G.h4s6.09
Polar TM3 R 149 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM3 R 149 3x50 G.H5 G 352 G.H5.24
Van-der-waals TM3 R 149 3x50 G.H5 G 352 G.H5.24
Ionic H8 R 334 8x53 G.h4s6 D 316 G.h4s6.10
Polar H8 R 334 8x53 G.h4s6 D 316 G.h4s6.10
Hydrophobic H8 R 334 8x53 G.h4s6 D 316 G.h4s6.10
Van-der-waals H8 R 334 8x53 G.h4s6 D 316 G.h4s6.10
Polar ICL2 G 161 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 G 161 34x55 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 G 161 34x55 G.hns1 A 31 G.hns1.02
Polar ICL2 L 157 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 157 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 157 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic TM2 I 86 2x39 G.H5 G 352 G.H5.24
Polar TM6 K 257 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 257 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 257 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM7 A 327 7x56 G.H5 G 352 G.H5.24
Hydrophobic C-term L 362 - G.H2 K 209 G.H2.05
Hydrophobic TM3 G 152 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 G 152 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 160 34x54 G.H5 I 343 G.H5.15
Polar ICL2 R 162 34x56 G.HN A 27 G.HN.51
Hydrophobic ICL2 R 162 34x56 G.HN A 27 G.HN.51
Van-der-waals ICL2 R 162 34x56 G.HN A 27 G.HN.51
Hydrophobic TM2 I 86 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 I 86 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 L 254 6x30 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 254 6x30 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 160 34x54 G.S1 V 34 G.S1.02
Van-der-waals ICL2 L 160 34x54 G.S1 V 34 G.S1.02
Hydrophobic ICL2 L 163 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 L 163 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 156 34x50 G.H5 I 344 G.H5.16
Hydrophobic H8 D 329 8x48 G.H5 F 354 G.H5.26
Hydrophobic ICL2 L 157 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 157 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM3 G 152 3x53 G.H5 L 348 G.H5.20
Van-der-waals TM3 G 152 3x53 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 149 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 254 6x30 G.H5 F 354 G.H5.26
Hydrophobic ICL2 L 157 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 L 157 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM6 K 257 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 K 257 6x33 G.H5 L 353 G.H5.25