G12 - P2Y4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term L 335 - G.H3 N 283 G.H3.15
Van-der-waals C-term L 335 - G.H3 N 283 G.H3.15
Polar ICL2 L 144 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 L 144 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 R 145 34x55 G.S3 P 222 G.S3.02
Van-der-waals ICL2 R 145 34x55 G.S3 P 222 G.S3.02
Hydrophobic TM6 A 235 6x26 G.H5 Q 372 G.H5.17
Hydrophobic ICL1 P 66 - G.HN A 48 G.HN.48
Van-der-waals ICL1 P 66 - G.HN A 48 G.HN.48
Hydrophobic ICL2 R 145 34x55 G.S3 I 221 G.S3.01
Hydrophobic ICL2 P 140 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 140 34x50 G.H5 K 367 G.H5.12
Polar TM6 S 234 6x25 G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL2 L 144 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 144 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM7 T 309 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 T 309 7x56 G.H5 M 379 G.H5.24
Polar ICL2 R 145 34x55 G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 R 145 34x55 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 R 145 34x55 G.s2s3 K 220 G.s2s3.02
Hydrophobic TM3 I 137 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 137 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM5 R 226 5x64 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 226 5x64 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 141 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 141 34x51 G.H5 F 363 G.H5.08
Polar ICL3 P 232 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 P 232 - G.H5 Q 372 G.H5.17
Hydrophobic ICL2 P 140 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM2 D 68 2x37 G.H5 Q 381 G.H5.26
Hydrophobic TM6 S 239 6x30 G.H5 L 375 G.H5.20
Hydrophobic TM3 I 137 3x54 G.H5 L 375 G.H5.20
Hydrophobic H8 D 311 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 D 311 8x48 G.H5 L 380 G.H5.25
Hydrophobic TM6 S 243 6x34 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 243 6x34 G.H5 M 379 G.H5.24
Hydrophobic C-term L 335 - G.H2 F 239 G.H2.08
Hydrophobic TM4 R 148 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 R 148 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 L 141 34x51 G.H5 K 367 G.H5.12
Polar C-term S 333 - G.H3 K 284 G.H3.16
Van-der-waals C-term S 333 - G.H3 K 284 G.H3.16
Hydrophobic ICL3 G 233 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 G 233 - G.h4s6 P 345 G.h4s6.20
Hydrophobic C-term L 335 - G.H3 L 285 G.H3.17
Van-der-waals C-term L 335 - G.H3 L 285 G.H3.17
Hydrophobic TM6 S 239 6x30 G.H5 M 379 G.H5.24
Hydrophobic ICL3 P 232 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 P 232 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 P 232 - G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 141 34x51 G.S1 V 58 G.S1.02
Polar H8 G 310 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 G 310 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 G 310 8x47 G.H5 M 379 G.H5.24
Polar TM3 G 136 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 G 136 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 G 136 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM2 D 68 2x37 G.HN R 52 G.HN.52
Van-der-waals TM2 D 68 2x37 G.HN R 52 G.HN.52
Polar ICL2 R 145 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 R 145 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 145 34x55 G.hns1 R 56 G.hns1.03
Polar ICL1 W 67 - G.HN R 52 G.HN.52
Hydrophobic ICL1 W 67 - G.HN R 52 G.HN.52
Van-der-waals ICL1 W 67 - G.HN R 52 G.HN.52
Polar TM3 R 133 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 133 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 140 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL3 L 231 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 L 231 - G.H5 L 371 G.H5.16
Hydrophobic TM6 S 239 6x30 G.H5 K 376 G.H5.21
Hydrophobic TM6 R 242 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 R 242 6x33 G.H5 M 379 G.H5.24
Polar H8 K 312 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 K 312 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM5 L 227 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 227 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 141 34x51 G.H5 V 366 G.H5.11
Hydrophobic ICL3 L 231 - G.H5 L 375 G.H5.20
Van-der-waals ICL3 L 231 - G.H5 L 375 G.H5.20
Hydrophobic H8 G 310 8x47 G.H5 L 380 G.H5.25
Polar ICL1 P 66 - G.HN R 52 G.HN.52
Hydrophobic ICL1 P 66 - G.HN R 52 G.HN.52
Van-der-waals ICL1 P 66 - G.HN R 52 G.HN.52
Hydrophobic TM6 S 243 6x34 G.H5 L 375 G.H5.20
Polar TM4 R 148 4x38 G.HN A 53 G.HN.53
Hydrophobic ICL2 L 141 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 141 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 L 141 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 141 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 144 34x54 G.S1 V 58 G.S1.02
Hydrophobic TM4 P 149 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 P 149 4x39 G.HN R 52 G.HN.52
Hydrophobic TM3 G 136 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 G 136 3x53 G.H5 I 378 G.H5.23
Hydrophobic C-term L 337 - G.H2 F 239 G.H2.08
Van-der-waals C-term L 337 - G.H2 F 239 G.H2.08
Hydrophobic ICL2 L 144 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 L 144 34x54 G.hns1 R 55 G.hns1.02
Polar TM7 T 309 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM6 R 242 6x33 G.H5 L 380 G.H5.25
Hydrophobic H8 K 312 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 312 8x49 G.H5 Q 381 G.H5.26