Gs - P2Y6 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 128 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 128 3x54 G.H5 L 388 G.H5.20
Polar ICL2 G 139 34x58 G.HN Q 35 G.HN.52
Hydrophobic ICL2 G 139 34x58 G.HN Q 35 G.HN.52
Polar TM5 Q 222 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 222 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 222 5x68 G.H5 Q 384 G.H5.16
Ionic TM6 R 234 6x31 G.H5 D 381 G.H5.13
Polar TM6 R 234 6x31 G.H5 D 381 G.H5.13
Van-der-waals TM6 R 234 6x31 G.H5 D 381 G.H5.13
Hydrophobic TM6 M 240 6x37 G.H5 L 393 G.H5.25
Polar H8 K 306 8x48 G.H5 L 394 G.H5.26
Hydrophobic H8 K 306 8x48 G.H5 L 394 G.H5.26
Van-der-waals H8 K 306 8x48 G.H5 L 394 G.H5.26
Hydrophobic TM3 I 128 3x54 G.H5 H 387 G.H5.19
Polar ICL2 K 137 34x56 G.S1 H 41 G.S1.02
Van-der-waals ICL2 K 137 34x56 G.S1 H 41 G.S1.02
Polar TM6 R 233 6x30 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 R 233 6x30 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 R 233 6x30 G.h4s6 Y 358 G.h4s6.20
Polar TM3 Q 123 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 132 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 P 131 34x50 G.H5 Q 384 G.H5.16
Polar TM3 R 124 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 124 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 124 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 132 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL2 L 132 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 132 34x51 G.S1 H 41 G.S1.02
Polar TM7 T 304 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM7 T 304 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 T 304 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 233 6x30 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 219 5x65 G.H5 Q 384 G.H5.16
Hydrophobic TM6 A 241 6x38 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 128 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 128 3x54 G.H5 L 393 G.H5.25
Polar TM3 I 128 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 128 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 128 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 131 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 131 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 134 34x53 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 P 134 34x53 G.hns1 A 39 G.hns1.03
Hydrophobic TM6 R 233 6x30 G.H5 L 394 G.H5.26
Polar H8 Q 305 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 Q 305 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 Q 305 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM4 R 142 4x40 G.HN Q 31 G.HN.48
Hydrophobic TM5 L 219 5x65 G.H5 L 388 G.H5.20
Polar TM3 G 127 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 G 127 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 G 127 3x53 G.H5 H 387 G.H5.19
Polar TM6 R 234 6x31 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 132 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM6 A 230 6x27 G.H5 R 385 G.H5.17
Van-der-waals TM6 A 230 6x27 G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 132 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 132 34x51 G.H5 F 376 G.H5.08
Polar TM6 A 237 6x34 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 237 6x34 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 237 6x34 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 131 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 131 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM5 L 215 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 237 6x34 G.H5 L 388 G.H5.20
Van-der-waals TM6 A 237 6x34 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 128 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 132 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 132 34x51 G.H5 I 383 G.H5.15
Van-der-waals H8 R 310 8x52 G.h4s6 R 356 G.h4s6.12