G12 - P2RY10 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 81.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 139 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 139 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL2 A 141 34x53 G.H5 N 374 G.H5.19
Hydrophobic TM2 N 67 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM6 M 244 6x37 G.H5 M 379 G.H5.24
Ionic ICL2 D 143 34x55 G.hns1 R 56 G.hns1.03
Polar ICL2 D 143 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 D 143 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 D 143 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 Q 233 6x26 G.H5 L 371 G.H5.16
Van-der-waals TM6 Q 233 6x26 G.H5 L 371 G.H5.16
Hydrophobic ICL2 F 139 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM6 F 232 6x25 G.S6 F 347 G.S6.02
Van-der-waals TM6 F 232 6x25 G.S6 F 347 G.S6.02
Polar ICL2 P 138 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 138 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 D 143 34x55 G.HN R 52 G.HN.52
Hydrophobic TM5 L 225 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM1 L 59 1x57 G.H5 L 380 G.H5.25
Hydrophobic TM6 E 237 6x30 G.H5 M 379 G.H5.24
Van-der-waals TM6 E 237 6x30 G.H5 M 379 G.H5.24
Hydrophobic ICL2 F 139 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 F 139 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM3 L 135 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 L 135 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM6 M 244 6x37 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 138 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 138 34x50 G.H5 I 370 G.H5.15
Polar TM3 F 134 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 F 134 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 F 134 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 F 139 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 139 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM7 Y 306 7x54 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 241 6x34 G.H5 L 375 G.H5.20
Van-der-waals TM6 A 241 6x34 G.H5 L 375 G.H5.20
Hydrophobic TM7 A 309 7x57 G.H5 M 379 G.H5.24
Van-der-waals TM7 A 309 7x57 G.H5 M 379 G.H5.24
Hydrophobic ICL3 M 230 - G.H5 R 360 G.H5.05
Hydrophobic ICL3 A 231 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 A 231 - G.S6 F 347 G.S6.02
Polar ICL3 A 231 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 A 231 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 A 231 - G.H5 D 368 G.H5.13
Hydrophobic TM2 I 70 2x40 G.H5 L 380 G.H5.25
Hydrophobic TM6 F 232 6x25 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 F 232 6x25 G.h4s6 P 345 G.h4s6.20
Polar ICL2 R 142 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 R 142 34x54 G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 R 142 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic TM1 I 63 1x61 G.H5 L 380 G.H5.25
Hydrophobic TM6 K 240 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 240 6x33 G.H5 M 379 G.H5.24
Polar ICL3 M 230 - G.H5 D 368 G.H5.13
Hydrophobic TM3 L 135 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 135 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM3 L 135 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 135 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL3 M 230 - G.H5 H 364 G.H5.09
Van-der-waals ICL3 M 230 - G.H5 H 364 G.H5.09
Hydrophobic TM4 K 145 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 K 145 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 P 138 34x50 G.H5 L 371 G.H5.16
Polar ICL2 R 142 34x54 G.S1 L 57 G.S1.01
Van-der-waals ICL2 R 142 34x54 G.S1 L 57 G.S1.01
Hydrophobic TM7 A 309 7x57 G.H5 L 380 G.H5.25
Van-der-waals TM7 A 309 7x57 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 139 34x51 G.S3 F 223 G.S3.03
Hydrophobic TM2 M 73 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 M 73 2x43 G.H5 L 380 G.H5.25
Hydrophobic ICL2 D 143 34x55 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 D 143 34x55 G.hns1 R 55 G.hns1.02
Polar TM6 E 237 6x30 G.H5 Q 381 G.H5.26
Hydrophobic TM6 E 237 6x30 G.H5 Q 381 G.H5.26
Van-der-waals TM6 E 237 6x30 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 R 142 34x54 G.H5 I 370 G.H5.15
Aromatic ICL2 F 139 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 139 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 139 34x51 G.H5 F 363 G.H5.08
Polar TM6 Q 233 6x26 G.H5 D 368 G.H5.13
Hydrophobic TM6 Q 233 6x26 G.H5 D 368 G.H5.13
Van-der-waals TM6 Q 233 6x26 G.H5 D 368 G.H5.13
Polar TM7 E 311 7x59 G.H5 Q 381 G.H5.26
Hydrophobic TM7 E 311 7x59 G.H5 Q 381 G.H5.26
Van-der-waals TM7 E 311 7x59 G.H5 Q 381 G.H5.26
Hydrophobic TM6 F 232 6x25 G.S6 H 348 G.S6.03
Polar TM3 R 131 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 F 134 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM6 A 241 6x34 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 241 6x34 G.H5 M 379 G.H5.24
Polar TM7 S 310 7x58 G.H5 Q 381 G.H5.26
Hydrophobic TM7 S 310 7x58 G.H5 Q 381 G.H5.26
Van-der-waals TM7 S 310 7x58 G.H5 Q 381 G.H5.26
Polar TM7 E 311 7x59 G.H5 L 380 G.H5.25
Hydrophobic TM7 E 311 7x59 G.H5 L 380 G.H5.25
Van-der-waals TM7 E 311 7x59 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 139 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 139 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL3 A 231 - G.H5 A 365 G.H5.10
Hydrophobic TM2 N 67 2x37 G.H5 L 380 G.H5.25
Polar TM7 S 310 7x58 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 138 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 138 34x50 G.H5 K 367 G.H5.12