GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL2 | R | 142 | 34x54 | G.S1 | L | 57 | G.S1.01 |
Van-der-waals | ICL2 | R | 142 | 34x54 | G.S1 | L | 57 | G.S1.01 |
Hydrophobic | ICL3 | A | 231 | - | G.H5 | A | 365 | G.H5.10 |
Polar | ICL3 | Q | 233 | - | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | ICL3 | Q | 233 | - | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | ICL3 | Q | 233 | - | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM6 | A | 241 | 6x34 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | A | 241 | 6x34 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM1 | L | 59 | 1x57 | G.H5 | L | 380 | G.H5.25 |
Polar | TM3 | F | 134 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | F | 134 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | F | 134 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM7 | A | 309 | 7x57 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | A | 309 | 7x57 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL3 | M | 230 | - | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | ICL2 | F | 139 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | F | 139 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | ICL2 | F | 139 | 34x51 | G.S3 | F | 223 | G.S3.03 |
Hydrophobic | ICL2 | P | 138 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | ICL2 | P | 138 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | ICL2 | F | 139 | 34x51 | G.S1 | V | 58 | G.S1.02 |
Van-der-waals | ICL2 | F | 139 | 34x51 | G.S1 | V | 58 | G.S1.02 |
Hydrophobic | TM7 | A | 309 | 7x57 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM7 | A | 309 | 7x57 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL3 | M | 230 | - | G.H5 | H | 364 | G.H5.09 |
Van-der-waals | ICL3 | M | 230 | - | G.H5 | H | 364 | G.H5.09 |
Hydrophobic | TM3 | F | 134 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Polar | TM7 | E | 311 | 7x59 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM7 | E | 311 | 7x59 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | E | 311 | 7x59 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL2 | P | 138 | 34x50 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | P | 138 | 34x50 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM6 | E | 237 | 6x30 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | E | 237 | 6x30 | G.H5 | M | 379 | G.H5.24 |
Polar | TM7 | E | 311 | 7x59 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM7 | E | 311 | 7x59 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM7 | E | 311 | 7x59 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM3 | L | 135 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM3 | L | 135 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | ICL3 | F | 232 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | ICL3 | F | 232 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | TM6 | M | 244 | 6x37 | G.H5 | I | 378 | G.H5.23 |
Aromatic | ICL2 | F | 139 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | ICL2 | F | 139 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | F | 139 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | ICL2 | P | 138 | 34x50 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | ICL3 | Q | 233 | - | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | ICL3 | Q | 233 | - | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM3 | L | 135 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | L | 135 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM7 | Y | 306 | 7x54 | G.H5 | L | 380 | G.H5.25 |
Polar | TM3 | R | 131 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 131 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 131 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | ICL2 | F | 139 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | F | 139 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | ICL2 | D | 143 | 34x55 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | D | 143 | 34x55 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM3 | L | 135 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | L | 135 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM4 | K | 145 | 4x38 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | TM4 | K | 145 | 4x38 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM6 | A | 241 | 6x34 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM6 | A | 241 | 6x34 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | R | 142 | 34x54 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM6 | K | 240 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | K | 240 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL3 | A | 231 | - | G.S6 | F | 347 | G.S6.02 |
Van-der-waals | ICL3 | A | 231 | - | G.S6 | F | 347 | G.S6.02 |
Polar | TM7 | S | 310 | 7x58 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | M | 244 | 6x37 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL3 | F | 232 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | ICL2 | F | 139 | 34x51 | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | ICL2 | F | 139 | 34x51 | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | ICL2 | D | 143 | 34x55 | G.HN | R | 52 | G.HN.52 |
Hydrophobic | ICL3 | F | 232 | - | G.S6 | F | 347 | G.S6.02 |
Van-der-waals | ICL3 | F | 232 | - | G.S6 | F | 347 | G.S6.02 |
Polar | TM6 | E | 237 | 6x30 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM6 | E | 237 | 6x30 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM6 | E | 237 | 6x30 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | ICL2 | P | 138 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | P | 138 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM2 | M | 73 | 2x43 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM2 | M | 73 | 2x43 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM2 | I | 70 | 2x40 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM1 | I | 63 | 1x61 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | F | 139 | 34x51 | G.H5 | V | 366 | G.H5.11 |
Hydrophobic | ICL2 | A | 141 | 34x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM2 | N | 67 | 2x37 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL2 | R | 142 | 34x54 | G.h2s4 | T | 246 | G.h2s4.05 |
Hydrophobic | ICL2 | R | 142 | 34x54 | G.h2s4 | T | 246 | G.h2s4.05 |
Van-der-waals | ICL2 | R | 142 | 34x54 | G.h2s4 | T | 246 | G.h2s4.05 |
Ionic | ICL2 | D | 143 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Polar | ICL2 | D | 143 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | D | 143 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | D | 143 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Polar | ICL3 | A | 231 | - | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | ICL3 | A | 231 | - | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | ICL3 | A | 231 | - | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM2 | N | 67 | 2x37 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | ICL3 | M | 230 | - | G.H5 | R | 360 | G.H5.05 |
Hydrophobic | TM5 | L | 225 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Polar | TM7 | S | 310 | 7x58 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM7 | S | 310 | 7x58 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM7 | S | 310 | 7x58 | G.H5 | Q | 381 | G.H5.26 |