Gt1 -
P2Y11 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | W | 342 | - | G.H2 | I | 208 | G.H2.08 |
Hydrophobic | C-term | L | 356 | - | G.hgh4 | D | 285 | G.hgh4.04 |
Hydrophobic | ICL2 | F | 135 | 34x51 | G.S3 | L | 190 | G.S3.01 |
Van-der-waals | ICL2 | F | 135 | 34x51 | G.S3 | L | 190 | G.S3.01 |
Hydrophobic | ICL3 | G | 237 | - | G.S6 | Y | 316 | G.S6.02 |
Hydrophobic | ICL2 | F | 135 | 34x51 | G.H5 | T | 336 | G.H5.12 |
Van-der-waals | ICL2 | F | 135 | 34x51 | G.H5 | T | 336 | G.H5.12 |
Polar | ICL2 | S | 139 | 34x55 | G.hns1 | R | 28 | G.hns1.03 |
Hydrophobic | ICL2 | S | 139 | 34x55 | G.hns1 | R | 28 | G.hns1.03 |
Van-der-waals | ICL2 | S | 139 | 34x55 | G.hns1 | R | 28 | G.hns1.03 |
Hydrophobic | C-term | W | 342 | - | G.H3 | L | 245 | G.H3.08 |
Polar | TM3 | N | 126 | 3x49 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | N | 126 | 3x49 | G.H5 | C | 347 | G.H5.23 |
Ionic | TM2 | H | 62 | 2x37 | G.H5 | D | 346 | G.H5.22 |
Polar | TM2 | H | 62 | 2x37 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM2 | H | 62 | 2x37 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | TM2 | H | 62 | 2x37 | G.H5 | D | 346 | G.H5.22 |
Ionic | C-term | D | 340 | - | G.H3 | R | 253 | G.H3.16 |
Polar | C-term | D | 340 | - | G.H3 | R | 253 | G.H3.16 |
Hydrophobic | C-term | D | 340 | - | G.H3 | R | 253 | G.H3.16 |
Van-der-waals | C-term | D | 340 | - | G.H3 | R | 253 | G.H3.16 |
Hydrophobic | ICL2 | R | 138 | 34x54 | G.H5 | I | 339 | G.H5.15 |
Van-der-waals | ICL2 | R | 138 | 34x54 | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | C-term | A | 347 | - | G.H3 | H | 244 | G.H3.07 |
Polar | ICL2 | R | 138 | 34x54 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | ICL2 | R | 138 | 34x54 | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | ICL2 | R | 138 | 34x54 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | TM2 | A | 64 | 2x39 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | TM2 | A | 64 | 2x39 | G.H5 | D | 346 | G.H5.22 |
Polar | TM3 | R | 127 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | R | 127 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | R | 127 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL2 | P | 134 | 34x50 | G.H5 | T | 336 | G.H5.12 |
Hydrophobic | TM3 | I | 131 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM3 | I | 131 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Aromatic | C-term | W | 342 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Hydrophobic | C-term | W | 342 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Hydrophobic | TM3 | I | 131 | 3x54 | G.H5 | I | 340 | G.H5.16 |
Ionic | H8 | H | 334 | 8x56 | G.h2s4 | E | 212 | G.h2s4.02 |
Polar | C-term | W | 342 | - | G.H3 | S | 248 | G.H3.11 |
Hydrophobic | C-term | W | 342 | - | G.H3 | S | 248 | G.H3.11 |
Hydrophobic | TM3 | R | 127 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM3 | R | 127 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM7 | A | 324 | 7x56 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | TM7 | A | 324 | 7x56 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | H8 | L | 328 | 8x50 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | H8 | L | 328 | 8x50 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | TM4 | R | 142 | 4x38 | G.hns1 | R | 28 | G.hns1.03 |
Hydrophobic | ICL3 | M | 238 | - | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | C-term | P | 344 | - | G.H2 | R | 204 | G.H2.04 |
Polar | TM3 | G | 130 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM3 | G | 130 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | TM3 | G | 130 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | C-term | L | 356 | - | G.hgh4 | P | 284 | G.hgh4.03 |
Hydrophobic | C-term | L | 356 | - | G.H3 | H | 240 | G.H3.03 |
Hydrophobic | C-term | W | 342 | - | G.H3 | I | 249 | G.H3.12 |
Polar | C-term | W | 342 | - | G.H3 | H | 252 | G.H3.15 |
Aromatic | C-term | W | 342 | - | G.H3 | H | 252 | G.H3.15 |
Hydrophobic | C-term | W | 342 | - | G.H3 | H | 252 | G.H3.15 |
Van-der-waals | C-term | W | 342 | - | G.H3 | H | 252 | G.H3.15 |
Hydrophobic | ICL3 | M | 238 | - | G.H5 | K | 341 | G.H5.17 |
Aromatic | C-term | Y | 338 | - | G.H3 | R | 253 | G.H3.16 |
Polar | H8 | C | 331 | 8x53 | G.h3s5 | T | 257 | G.h3s5.02 |
Hydrophobic | H8 | C | 331 | 8x53 | G.h3s5 | T | 257 | G.h3s5.02 |
Van-der-waals | H8 | C | 331 | 8x53 | G.h3s5 | T | 257 | G.h3s5.02 |
Hydrophobic | C-term | W | 342 | - | G.H2 | R | 204 | G.H2.04 |
Van-der-waals | C-term | W | 342 | - | G.H2 | R | 204 | G.H2.04 |
Ionic | TM6 | E | 242 | 6x30 | G.H5 | K | 341 | G.H5.17 |
Polar | TM6 | E | 242 | 6x30 | G.H5 | K | 341 | G.H5.17 |
Hydrophobic | TM6 | E | 242 | 6x30 | G.H5 | K | 341 | G.H5.17 |
Van-der-waals | TM6 | E | 242 | 6x30 | G.H5 | K | 341 | G.H5.17 |
Hydrophobic | TM6 | L | 249 | 6x37 | G.H5 | L | 349 | G.H5.25 |
Ionic | TM4 | R | 142 | 4x38 | G.HN | E | 24 | G.HN.52 |
Polar | TM4 | R | 142 | 4x38 | G.HN | E | 24 | G.HN.52 |
Hydrophobic | TM4 | R | 142 | 4x38 | G.HN | E | 24 | G.HN.52 |
Van-der-waals | TM4 | R | 142 | 4x38 | G.HN | E | 24 | G.HN.52 |
Aromatic | ICL2 | F | 135 | 34x51 | G.H5 | F | 332 | G.H5.08 |
Hydrophobic | ICL2 | F | 135 | 34x51 | G.H5 | F | 332 | G.H5.08 |
Van-der-waals | ICL2 | F | 135 | 34x51 | G.H5 | F | 332 | G.H5.08 |
Polar | ICL3 | G | 237 | - | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | ICL3 | G | 237 | - | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | ICL3 | G | 237 | - | G.H5 | D | 337 | G.H5.13 |
Polar | ICL3 | G | 237 | - | G.H5 | K | 341 | G.H5.17 |
Hydrophobic | ICL3 | G | 237 | - | G.H5 | K | 341 | G.H5.17 |
Van-der-waals | ICL3 | G | 237 | - | G.H5 | K | 341 | G.H5.17 |
Hydrophobic | TM6 | V | 246 | 6x34 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | ICL3 | M | 238 | - | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | ICL3 | M | 238 | - | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | H8 | P | 326 | 8x48 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | H8 | P | 326 | 8x48 | G.H5 | F | 350 | G.H5.26 |
Ionic | ICL2 | R | 138 | 34x54 | G.H5 | E | 342 | G.H5.18 |
Polar | ICL2 | R | 138 | 34x54 | G.H5 | E | 342 | G.H5.18 |
Hydrophobic | ICL2 | R | 138 | 34x54 | G.H5 | E | 342 | G.H5.18 |
Van-der-waals | ICL2 | R | 138 | 34x54 | G.H5 | E | 342 | G.H5.18 |
Polar | ICL2 | P | 134 | 34x50 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | ICL2 | P | 134 | 34x50 | G.H5 | I | 339 | G.H5.15 |
Van-der-waals | ICL2 | P | 134 | 34x50 | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | TM6 | V | 246 | 6x34 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM6 | V | 246 | 6x34 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM5 | L | 228 | 5x61 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | H8 | V | 325 | 8x47 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | TM6 | V | 250 | 6x38 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | H8 | P | 326 | 8x48 | G.H5 | K | 345 | G.H5.21 |
Van-der-waals | H8 | P | 326 | 8x48 | G.H5 | K | 345 | G.H5.21 |
Hydrophobic | ICL2 | F | 135 | 34x51 | G.H5 | I | 339 | G.H5.15 |
Van-der-waals | ICL2 | F | 135 | 34x51 | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | ICL3 | P | 236 | - | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | ICL3 | P | 236 | - | G.H5 | D | 337 | G.H5.13 |
Ionic | ICL1 | R | 59 | - | G.HN | E | 16 | G.HN.44 |
Polar | ICL1 | R | 59 | - | G.HN | E | 16 | G.HN.44 |
Polar | ICL3 | S | 235 | - | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | ICL3 | S | 235 | - | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | ICL2 | P | 134 | 34x50 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | TM6 | E | 242 | 6x30 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | E | 242 | 6x30 | G.H5 | F | 350 | G.H5.26 |
Polar | TM6 | R | 245 | 6x33 | G.H5 | F | 350 | G.H5.26 |
Aromatic | TM6 | R | 245 | 6x33 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM6 | R | 245 | 6x33 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | R | 245 | 6x33 | G.H5 | F | 350 | G.H5.26 |
Polar | TM3 | R | 127 | 3x50 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | TM2 | A | 64 | 2x39 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL3 | G | 237 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Van-der-waals | ICL3 | G | 237 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | C-term | W | 342 | - | G.H2 | W | 207 | G.H2.07 |
Van-der-waals | C-term | W | 342 | - | G.H2 | W | 207 | G.H2.07 |
Hydrophobic | TM3 | I | 131 | 3x54 | G.H5 | L | 349 | G.H5.25 |