Gz - P2Y11 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 P 134 34x50 G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 134 34x50 G.H5 N 348 G.H5.19
Hydrophobic C-term W 342 - G.H2 I 213 G.H2.08
Polar ICL3 P 236 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 P 236 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 P 236 - G.H5 D 342 G.H5.13
Polar TM6 E 242 6x30 G.H5 Q 346 G.H5.17
Hydrophobic TM6 E 242 6x30 G.H5 Q 346 G.H5.17
Van-der-waals TM6 E 242 6x30 G.H5 Q 346 G.H5.17
Hydrophobic TM6 V 250 6x38 G.H5 L 354 G.H5.25
Hydrophobic ICL2 S 139 34x55 G.S3 L 195 G.S3.01
Hydrophobic C-term W 342 - G.h2s4 F 216 G.h2s4.01
Hydrophobic C-term W 342 - G.H2 R 209 G.H2.04
Van-der-waals C-term W 342 - G.H2 R 209 G.H2.04
Van-der-waals ICL3 G 237 - G.h4s6 E 319 G.h4s6.12
Hydrophobic C-term L 356 - G.hgh4 P 289 G.hgh4.03
Van-der-waals C-term L 356 - G.hgh4 P 289 G.hgh4.03
Polar ICL2 S 139 34x55 G.s2s3 E 194 G.s2s3.02
Hydrophobic TM5 L 228 5x61 G.H5 L 354 G.H5.25
Polar TM3 R 127 3x50 G.H5 G 353 G.H5.24
Van-der-waals TM3 R 127 3x50 G.H5 G 353 G.H5.24
Hydrophobic H8 V 325 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 V 325 8x47 G.H5 G 353 G.H5.24
Hydrophobic ICL2 F 135 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 F 135 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL2 P 134 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM3 R 127 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 127 3x50 G.H5 L 354 G.H5.25
Hydrophobic C-term W 342 - G.H3 I 254 G.H3.12
Van-der-waals C-term W 342 - G.H3 I 254 G.H3.12
Polar ICL2 R 138 34x54 G.S1 E 33 G.S1.01
Van-der-waals ICL2 R 138 34x54 G.S1 E 33 G.S1.01
Van-der-waals TM4 R 142 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 138 34x54 G.S3 L 195 G.S3.01
Hydrophobic H8 P 326 8x48 G.H5 G 353 G.H5.24
Hydrophobic TM2 A 64 2x39 G.H5 I 352 G.H5.23
Hydrophobic TM2 A 64 2x39 G.H5 Y 351 G.H5.22
Hydrophobic C-term P 344 - G.H2 R 209 G.H2.04
Van-der-waals C-term P 344 - G.H2 R 209 G.H2.04
Hydrophobic H8 P 326 8x48 G.H5 K 350 G.H5.21
Van-der-waals H8 P 326 8x48 G.H5 K 350 G.H5.21
Polar H8 C 331 8x53 G.h3s5 N 262 G.h3s5.02
Hydrophobic H8 C 331 8x53 G.h3s5 N 262 G.h3s5.02
Van-der-waals H8 C 331 8x53 G.h3s5 N 262 G.h3s5.02
Polar TM4 R 142 4x38 G.HN Q 28 G.HN.52
Hydrophobic TM4 R 142 4x38 G.HN Q 28 G.HN.52
Van-der-waals TM4 R 142 4x38 G.HN Q 28 G.HN.52
Van-der-waals H8 P 326 8x48 G.H5 C 355 G.H5.26
Hydrophobic ICL2 P 134 34x50 G.H5 T 341 G.H5.12
Hydrophobic ICL3 M 238 - G.H5 L 349 G.H5.20
Van-der-waals ICL3 M 238 - G.H5 L 349 G.H5.20
Hydrophobic TM6 V 246 6x34 G.H5 L 349 G.H5.20
Polar C-term W 342 - G.H3 S 253 G.H3.11
Van-der-waals C-term W 342 - G.H3 S 253 G.H3.11
Aromatic ICL2 H 140 34x56 G.hns1 R 32 G.hns1.03
Polar H8 C 330 8x52 G.h3s5 N 262 G.h3s5.02
Polar ICL3 S 235 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 S 235 - G.H5 D 342 G.H5.13
Hydrophobic TM3 I 131 3x54 G.H5 I 345 G.H5.16
Hydrophobic TM3 I 131 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 131 3x54 G.H5 L 349 G.H5.20
Polar TM3 R 127 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 R 127 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 127 3x50 G.H5 I 352 G.H5.23
Hydrophobic H8 C 335 8x57 G.H3 W 259 G.H3.17
Van-der-waals H8 C 335 8x57 G.H3 W 259 G.H3.17
Hydrophobic TM3 I 131 3x54 G.H5 L 354 G.H5.25
Hydrophobic TM6 V 246 6x34 G.H5 C 355 G.H5.26
Hydrophobic ICL2 F 135 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 F 135 34x51 G.H5 I 344 G.H5.15
Hydrophobic TM6 R 245 6x33 G.H5 C 355 G.H5.26
Van-der-waals TM6 R 245 6x33 G.H5 C 355 G.H5.26
Hydrophobic ICL3 G 237 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 G 237 - G.S6 Y 321 G.S6.02
Polar ICL3 G 237 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 G 237 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 G 237 - G.H5 D 342 G.H5.13
Polar TM2 H 62 2x37 G.H5 Y 351 G.H5.22
Hydrophobic TM2 H 62 2x37 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 F 135 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 F 135 34x51 G.H5 T 341 G.H5.12
Hydrophobic ICL2 P 134 34x50 G.H5 I 345 G.H5.16
Hydrophobic C-term W 342 - G.H2 W 212 G.H2.07
Van-der-waals C-term W 342 - G.H2 W 212 G.H2.07
Polar TM3 G 130 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 G 130 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 G 130 3x53 G.H5 N 348 G.H5.19
Hydrophobic H8 L 328 8x50 G.H5 Y 351 G.H5.22
Van-der-waals H8 L 328 8x50 G.H5 Y 351 G.H5.22
Van-der-waals C-term W 342 - G.H3 N 257 G.H3.15
Hydrophobic ICL2 F 135 34x51 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 F 135 34x51 G.s2s3 K 193 G.s2s3.01
Ionic ICL2 H 140 34x56 G.s2s3 E 194 G.s2s3.02
Polar ICL2 H 140 34x56 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 H 140 34x56 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 H 140 34x56 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 F 135 34x51 G.S3 F 197 G.S3.03
Polar ICL2 R 138 34x54 G.h2s4 T 220 G.h2s4.05
Hydrophobic ICL2 R 138 34x54 G.h2s4 T 220 G.h2s4.05
Hydrophobic TM3 I 131 3x54 G.H5 I 352 G.H5.23
Van-der-waals TM3 I 131 3x54 G.H5 I 352 G.H5.23
Polar ICL2 S 139 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 S 139 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 S 139 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals TM6 T 239 6x27 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 R 138 34x54 G.S1 I 34 G.S1.02
Van-der-waals ICL2 R 138 34x54 G.S1 I 34 G.S1.02
Hydrophobic TM6 V 246 6x34 G.H5 L 354 G.H5.25
Van-der-waals TM6 V 246 6x34 G.H5 L 354 G.H5.25
Hydrophobic TM7 A 324 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 A 324 7x56 G.H5 G 353 G.H5.24
Polar ICL2 R 138 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 R 138 34x54 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 138 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic TM6 L 249 6x37 G.H5 L 354 G.H5.25