G12 - P2Y14 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 K 122 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 K 122 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 K 122 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 127 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 127 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 L 127 34x51 G.H5 V 366 G.H5.11
Hydrophobic H8 Q 300 8x48 G.H5 M 379 G.H5.24
Van-der-waals H8 Q 300 8x48 G.H5 M 379 G.H5.24
Polar ICL2 T 129 34x53 G.hns1 V 54 G.hns1.01
Van-der-waals ICL2 T 129 34x53 G.hns1 V 54 G.hns1.01
Hydrophobic ICL2 P 126 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 126 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM3 I 123 3x54 G.H5 I 378 G.H5.23
Ionic TM5 K 212 5x64 G.H5 D 368 G.H5.13
Hydrophobic ICL2 L 127 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 127 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM3 I 123 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 123 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM6 I 235 6x38 G.H5 L 380 G.H5.25
Van-der-waals TM6 I 235 6x38 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 127 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 127 34x51 G.S1 V 58 G.S1.02
Polar TM5 H 217 5x69 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 L 127 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM7 L 298 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 L 298 7x56 G.H5 M 379 G.H5.24
Hydrophobic TM5 I 213 5x65 G.H5 L 380 G.H5.25
Van-der-waals ICL2 T 129 34x53 G.hns1 R 55 G.hns1.02
Ionic TM2 K 54 2x37 G.H5 D 377 G.H5.22
Polar TM2 K 54 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 K 54 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 K 54 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM6 N 234 6x37 G.H5 L 380 G.H5.25
Van-der-waals TM6 N 234 6x37 G.H5 L 380 G.H5.25
Hydrophobic TM3 K 122 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 K 122 3x53 G.H5 I 378 G.H5.23
Polar ICL1 S 53 - G.HN R 52 G.HN.52
Hydrophobic ICL1 S 53 - G.HN R 52 G.HN.52
Van-der-waals ICL1 S 53 - G.HN R 52 G.HN.52
Hydrophobic TM5 I 209 5x61 G.H5 L 380 G.H5.25
Polar ICL2 T 129 34x53 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 T 129 34x53 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 T 129 34x53 G.hns1 R 56 G.hns1.03
Polar TM6 S 231 6x34 G.H5 L 380 G.H5.25
Hydrophobic TM6 S 231 6x34 G.H5 L 380 G.H5.25
Van-der-waals TM6 S 231 6x34 G.H5 L 380 G.H5.25
Hydrophobic TM5 K 212 5x64 G.H5 L 371 G.H5.16
Aromatic ICL3 K 219 - G.H5 H 364 G.H5.09
Hydrophobic H8 C 299 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 C 299 8x47 G.H5 M 379 G.H5.24
Hydrophobic TM5 I 213 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 I 213 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 127 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 127 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 W 128 34x52 G.S3 I 221 G.S3.01
Hydrophobic TM3 I 123 3x54 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 126 34x50 G.H5 L 371 G.H5.16
Hydrophobic H8 P 301 8x49 G.H5 M 379 G.H5.24
Van-der-waals H8 P 301 8x49 G.H5 M 379 G.H5.24
Polar ICL2 P 126 34x50 G.hns1 R 56 G.hns1.03
Polar TM4 S 136 4x40 G.HN R 49 G.HN.49
Van-der-waals TM4 S 136 4x40 G.HN R 49 G.HN.49
Polar ICL2 P 126 34x50 G.H5 N 374 G.H5.19
Hydrophobic TM5 S 216 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 S 216 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM3 I 123 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 126 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 126 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM6 V 227 6x30 G.H5 Q 381 G.H5.26
Van-der-waals TM6 V 227 6x30 G.H5 Q 381 G.H5.26
Hydrophobic TM3 R 119 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 119 3x50 G.H5 I 378 G.H5.23
Polar TM6 N 234 6x37 G.H5 M 379 G.H5.24
Van-der-waals TM6 N 234 6x37 G.H5 M 379 G.H5.24
Hydrophobic TM7 L 298 7x56 G.H5 L 380 G.H5.25
Polar TM5 S 216 5x68 G.H5 Q 372 G.H5.17
Polar TM6 K 230 6x33 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 230 6x33 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 230 6x33 G.H5 Q 381 G.H5.26