GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Aromatic | ICL2 | F | 199 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | ICL2 | F | 199 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | F | 199 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | TM6 | W | 296 | 6x31 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM6 | W | 296 | 6x31 | G.H5 | L | 368 | G.H5.20 |
Polar | TM2 | T | 128 | 2x39 | G.H5 | E | 370 | G.H5.22 |
Polar | ICL2 | G | 203 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | G | 203 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Polar | C-term | T | 364 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | C-term | T | 364 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | C-term | T | 364 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | TM4 | K | 206 | 4x38 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM4 | K | 206 | 4x38 | G.H5 | Y | 367 | G.H5.19 |
Polar | C-term | N | 366 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | C-term | N | 366 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | C-term | N | 366 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Ionic | TM4 | K | 206 | 4x38 | G.H5 | E | 370 | G.H5.22 |
Polar | TM4 | K | 206 | 4x38 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | TM4 | K | 206 | 4x38 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM6 | W | 298 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | W | 298 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | L | 372 | - | G.h4s6 | Y | 320 | G.h4s6.02 |
Hydrophobic | TM3 | I | 195 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM3 | I | 195 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL2 | P | 198 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM6 | Y | 299 | 6x34 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM3 | I | 195 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | I | 195 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | ICL2 | F | 199 | 34x51 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | C-term | H | 367 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | C-term | H | 367 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | TM6 | Y | 299 | 6x34 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | Y | 299 | 6x34 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | Y | 299 | 6x34 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | L | 372 | - | G.h4s6 | T | 321 | G.h4s6.03 |
Van-der-waals | C-term | L | 372 | - | G.h4s6 | T | 321 | G.h4s6.03 |
Polar | ICL2 | R | 202 | 34x54 | G.S1 | E | 42 | G.S1.01 |
Hydrophobic | ICL2 | F | 199 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | F | 199 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM3 | A | 194 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | A | 194 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM6 | W | 296 | 6x31 | G.H5 | A | 365 | G.H5.17 |
Hydrophobic | ICL2 | P | 205 | 34x57 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | P | 205 | 34x57 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | C-term | S | 362 | - | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | P | 198 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM5 | Y | 292 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM6 | Y | 299 | 6x34 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | Y | 299 | 6x34 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM3 | R | 191 | 3x50 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM2 | T | 128 | 2x39 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | N-term | M | 1 | - | G.s2s3 | K | 201 | G.s2s3.02 |
Van-der-waals | N-term | M | 1 | - | G.s2s3 | K | 201 | G.s2s3.02 |
Hydrophobic | ICL2 | F | 199 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | F | 199 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL2 | F | 199 | 34x51 | G.H5 | V | 359 | G.H5.11 |
Polar | TM5 | Y | 292 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | Y | 292 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | TM5 | Y | 292 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | Y | 292 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | Y | 292 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM6 | W | 296 | 6x31 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | W | 296 | 6x31 | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | C-term | R | 365 | - | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | C-term | R | 365 | - | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | C-term | R | 365 | - | G.H5 | L | 374 | G.H5.26 |
Polar | ICL2 | P | 198 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | P | 198 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | P | 198 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM5 | L | 289 | 5x65 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM3 | R | 191 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | R | 191 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Polar | ICL2 | R | 202 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | R | 202 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | R | 202 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Polar | ICL2 | R | 202 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | R | 202 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | R | 202 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Polar | ICL1 | S | 125 | - | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | ICL1 | S | 125 | - | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM6 | A | 302 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM3 | A | 194 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | A | 194 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Polar | C-term | T | 364 | - | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM5 | L | 289 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | C-term | T | 364 | - | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | C-term | T | 364 | - | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL2 | R | 202 | 34x54 | G.h2s4 | I | 227 | G.h2s4.05 |
Van-der-waals | ICL2 | R | 202 | 34x54 | G.h2s4 | I | 227 | G.h2s4.05 |
Hydrophobic | ICL2 | F | 199 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | F | 199 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | TM6 | W | 296 | 6x31 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM7 | M | 361 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | M | 361 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | S | 368 | - | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | C-term | S | 368 | - | G.H5 | L | 374 | G.H5.26 |
Polar | C-term | R | 365 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | C-term | R | 365 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | C-term | R | 365 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | TM3 | I | 195 | 3x54 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | W | 296 | 6x31 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | T | 369 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | ICL2 | R | 202 | 34x54 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | R | 202 | 34x54 | G.S1 | L | 43 | G.S1.02 |
Aromatic | ICL2 | Y | 201 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | Y | 201 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Polar | C-term | S | 368 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | C-term | S | 368 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | C-term | S | 368 | - | G.h4s6 | R | 335 | G.h4s6.17 |