Gi2 - PAR4 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 R 188 34x57 G.H5 C 352 G.H5.23
Hydrophobic ICL2 R 188 34x57 G.H5 C 352 G.H5.23
Van-der-waals ICL2 R 188 34x57 G.H5 C 352 G.H5.23
Hydrophobic ICL2 L 182 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 182 34x51 G.H5 I 344 G.H5.15
Hydrophobic TM2 S 111 2x39 G.H5 C 352 G.H5.23
Polar ICL2 A 186 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 A 186 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 A 186 34x55 G.hns1 R 32 G.hns1.03
Polar TM6 Y 278 6x31 G.H5 D 342 G.H5.13
Van-der-waals TM6 Y 278 6x31 G.H5 D 342 G.H5.13
Hydrophobic TM3 L 178 3x54 G.H5 I 345 G.H5.16
Hydrophobic ICL2 L 182 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 182 34x51 G.S3 L 195 G.S3.01
Polar ICL3 R 277 - G.S6 Y 321 G.S6.02
Hydrophobic ICL3 R 277 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 R 277 - G.S6 Y 321 G.S6.02
Hydrophobic TM3 L 178 3x54 G.H5 L 354 G.H5.25
Ionic ICL2 R 183 34x52 G.s2s3 D 194 G.s2s3.02
Polar ICL2 R 183 34x52 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 R 183 34x52 G.s2s3 D 194 G.s2s3.02
Ionic ICL3 R 277 - G.H5 D 342 G.H5.13
Polar ICL3 R 277 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 R 277 - G.H5 D 342 G.H5.13
Hydrophobic TM2 L 109 2x37 G.H5 D 351 G.H5.22
Ionic TM4 R 191 4x40 G.HN E 25 G.HN.49
Hydrophobic ICL2 P 181 34x50 G.H5 T 341 G.H5.12
Hydrophobic TM6 L 284 6x37 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 284 6x37 G.H5 L 354 G.H5.25
Polar ICL2 P 181 34x50 G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 181 34x50 G.H5 N 348 G.H5.19
Ionic ICL2 R 188 34x57 G.H5 D 351 G.H5.22
Polar ICL2 R 188 34x57 G.H5 D 351 G.H5.22
Hydrophobic ICL2 R 188 34x57 G.H5 D 351 G.H5.22
Van-der-waals ICL2 R 188 34x57 G.H5 D 351 G.H5.22
Polar TM3 R 174 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 174 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 174 3x50 G.H5 C 352 G.H5.23
Hydrophobic ICL2 L 182 34x51 G.H5 T 341 G.H5.12
Hydrophobic TM6 H 280 6x33 G.H5 F 355 G.H5.26
Polar TM3 A 177 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 177 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 177 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM4 R 191 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 R 191 4x40 G.HN R 24 G.HN.48
Hydrophobic TM6 H 280 6x33 G.H5 L 354 G.H5.25
Polar ICL2 R 185 34x54 G.h2s4 T 220 G.h2s4.05
Hydrophobic ICL2 R 185 34x54 G.h2s4 T 220 G.h2s4.05
Van-der-waals ICL2 R 185 34x54 G.h2s4 T 220 G.h2s4.05
Hydrophobic TM3 R 174 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 174 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 281 6x34 G.H5 L 349 G.H5.20
Van-der-waals TM6 A 281 6x34 G.H5 L 349 G.H5.20
Polar ICL2 R 185 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 185 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 185 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM3 L 178 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 L 178 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM6 A 281 6x34 G.H5 L 354 G.H5.25
Hydrophobic TM3 A 177 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 A 177 3x53 G.H5 C 352 G.H5.23
Ionic TM4 R 191 4x40 G.HN E 28 G.HN.52
Polar TM4 R 191 4x40 G.HN E 28 G.HN.52
Hydrophobic TM4 R 191 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 R 191 4x40 G.HN E 28 G.HN.52
Hydrophobic ICL2 P 181 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 181 34x50 G.H5 I 345 G.H5.16
Hydrophobic ICL2 R 185 34x54 G.hns1 R 32 G.hns1.03
Ionic ICL3 R 277 - G.h4s6 E 319 G.h4s6.12
Polar ICL3 R 277 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 R 277 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 R 277 - G.h4s6 E 319 G.h4s6.12
Polar ICL2 R 185 34x54 G.S1 E 33 G.S1.01
Van-der-waals ICL2 R 185 34x54 G.S1 E 33 G.S1.01
Polar TM3 D 173 3x49 G.H5 C 352 G.H5.23
Polar TM2 S 111 2x39 G.H5 D 351 G.H5.22
Hydrophobic TM2 S 111 2x39 G.H5 D 351 G.H5.22
Van-der-waals TM2 S 111 2x39 G.H5 D 351 G.H5.22
Hydrophobic ICL2 L 182 34x51 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 L 182 34x51 G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 R 185 34x54 G.S3 L 195 G.S3.01
Hydrophobic TM6 Y 278 6x31 G.H5 L 349 G.H5.20
Van-der-waals TM6 Y 278 6x31 G.H5 L 349 G.H5.20
Hydrophobic TM6 Y 278 6x31 G.H5 I 345 G.H5.16
Hydrophobic ICL2 R 185 34x54 G.S1 V 34 G.S1.02
Van-der-waals ICL2 R 185 34x54 G.S1 V 34 G.S1.02
Hydrophobic ICL2 P 181 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 181 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM3 L 178 3x54 G.H5 N 348 G.H5.19