Ggust -
EP1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 15.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL3 | S | 284 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | ICL3 | S | 284 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | ICL3 | S | 284 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Ionic | TM4 | R | 153 | 4x41 | G.HN | E | 28 | G.HN.52 |
Polar | TM4 | R | 153 | 4x41 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | R | 153 | 4x41 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | R | 153 | 4x41 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | L | 143 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | L | 143 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM3 | R | 135 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 135 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | L | 391 | - | G.H3 | H | 248 | G.H3.07 |
Hydrophobic | C-term | L | 391 | - | G.H3 | H | 248 | G.H3.07 |
Van-der-waals | C-term | L | 391 | - | G.H3 | H | 248 | G.H3.07 |
Polar | C-term | L | 399 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | C-term | L | 399 | - | G.H3 | S | 252 | G.H3.11 |
Van-der-waals | C-term | L | 399 | - | G.H3 | S | 252 | G.H3.11 |
Polar | TM2 | A | 70 | 2x36 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM2 | A | 70 | 2x36 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | A | 70 | 2x36 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL2 | L | 143 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | L | 143 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Polar | C-term | W | 386 | - | G.hgh4 | E | 289 | G.hgh4.04 |
Van-der-waals | C-term | W | 386 | - | G.hgh4 | E | 289 | G.hgh4.04 |
Hydrophobic | ICL2 | P | 142 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 142 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Polar | H8 | R | 355 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | R | 355 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | R | 355 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Polar | C-term | F | 402 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | F | 402 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | ICL2 | P | 142 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Ionic | TM5 | R | 236 | 5x70 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM5 | R | 236 | 5x70 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | R | 236 | 5x70 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM5 | R | 236 | 5x70 | G.h4s6 | E | 318 | G.h4s6.12 |
Ionic | TM5 | R | 236 | 5x70 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | R | 236 | 5x70 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | R | 236 | 5x70 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | R | 236 | 5x70 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM3 | R | 135 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 135 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | P | 142 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 142 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Polar | TM2 | R | 68 | 2x34 | G.HN | L | 23 | G.HN.47 |
Polar | TM4 | S | 150 | 4x38 | G.HN | Q | 24 | G.HN.48 |
Hydrophobic | C-term | F | 402 | - | G.H2 | K | 209 | G.H2.05 |
Van-der-waals | C-term | F | 402 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | C-term | L | 399 | - | G.H2 | W | 211 | G.H2.07 |
Hydrophobic | ICL2 | L | 143 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | L | 143 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | TM6 | M | 295 | 6x33 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | M | 295 | 6x33 | G.H5 | F | 354 | G.H5.26 |
Ionic | TM6 | R | 287 | 6x25 | G.h4s6 | E | 315 | G.h4s6.09 |
Polar | TM6 | R | 287 | 6x25 | G.h4s6 | E | 315 | G.h4s6.09 |
Hydrophobic | TM6 | R | 287 | 6x25 | G.h4s6 | E | 315 | G.h4s6.09 |
Van-der-waals | TM6 | R | 287 | 6x25 | G.h4s6 | E | 315 | G.h4s6.09 |
Aromatic | TM6 | H | 291 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | H | 291 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | H | 291 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | F | 402 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | TM6 | M | 295 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | Q | 298 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | L | 399 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | C-term | L | 399 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | C-term | L | 399 | - | G.H3 | I | 253 | G.H3.12 |
Van-der-waals | C-term | L | 399 | - | G.H3 | I | 253 | G.H3.12 |
Hydrophobic | TM2 | F | 73 | 2x39 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM2 | F | 73 | 2x39 | G.H5 | G | 352 | G.H5.24 |
Polar | TM3 | G | 138 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | G | 138 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | G | 138 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM2 | F | 73 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | F | 73 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Polar | C-term | S | 394 | - | G.H3 | E | 245 | G.H3.04 |
Polar | C-term | S | 397 | - | G.H3 | E | 245 | G.H3.04 |
Hydrophobic | C-term | S | 397 | - | G.H3 | E | 245 | G.H3.04 |
Van-der-waals | C-term | S | 397 | - | G.H3 | E | 245 | G.H3.04 |
Hydrophobic | ICL2 | A | 146 | 34x54 | G.H5 | I | 343 | G.H5.15 |
Polar | TM2 | R | 67 | 2x33 | G.h3s5 | T | 261 | G.h3s5.02 |
Polar | ICL2 | H | 145 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | H | 145 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | H | 145 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM5 | L | 229 | 5x63 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | L | 229 | 5x63 | G.H5 | L | 348 | G.H5.20 |
Polar | TM4 | S | 150 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | S | 150 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM3 | E | 134 | 3x49 | G.H5 | C | 351 | G.H5.23 |
Polar | TM2 | S | 69 | 2x35 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM2 | S | 69 | 2x35 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | S | 69 | 2x35 | G.H5 | D | 350 | G.H5.22 |
Polar | C-term | S | 397 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | S | 397 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | C-term | G | 398 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | TM6 | M | 295 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 295 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | L | 299 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM2 | F | 73 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | F | 73 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Polar | ICL2 | A | 147 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | A | 147 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | A | 147 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | C-term | L | 399 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Polar | C-term | W | 386 | - | G.H4 | Q | 306 | G.H4.14 |
Polar | C-term | S | 394 | - | G.H3 | H | 248 | G.H3.07 |
Hydrophobic | C-term | S | 394 | - | G.H3 | H | 248 | G.H3.07 |
Van-der-waals | C-term | S | 394 | - | G.H3 | H | 248 | G.H3.07 |
Hydrophobic | ICL2 | L | 143 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | L | 143 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Polar | TM5 | R | 236 | 5x70 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM5 | R | 236 | 5x70 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM4 | A | 152 | 4x40 | G.HN | Q | 24 | G.HN.48 |
Van-der-waals | TM4 | A | 152 | 4x40 | G.HN | Q | 24 | G.HN.48 |
Ionic | TM5 | R | 239 | 5x73 | G.H5 | D | 337 | G.H5.09 |
Polar | TM2 | S | 69 | 2x35 | G.H5 | E | 346 | G.H5.18 |
Polar | ICL2 | P | 142 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | P | 142 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | V | 139 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 139 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM2 | R | 68 | 2x34 | G.HN | A | 27 | G.HN.51 |
Van-der-waals | TM2 | R | 68 | 2x34 | G.HN | A | 27 | G.HN.51 |