G12 - IP receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term C 386 - H.hdhe F 173 H.hdhe.01
Hydrophobic C-term L 385 - H.hdhe F 173 H.hdhe.01
Polar C-term S 384 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term S 384 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term S 384 - G.s4h3 R 265 G.s4h3.12
Ionic ICL2 D 131 34x57 G.HN R 52 G.HN.52
Polar TM2 S 47 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 S 47 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 S 47 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 F 49 2x39 G.H5 L 380 G.H5.25
Polar TM3 A 120 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 120 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 120 3x53 G.H5 N 374 G.H5.19
Ionic ICL3 R 227 - G.H4 D 336 G.H4.16
Polar ICL3 R 227 - G.H4 D 336 G.H4.16
Hydrophobic ICL3 R 227 - G.H4 D 336 G.H4.16
Van-der-waals ICL3 R 227 - G.H4 D 336 G.H4.16
Hydrophobic TM3 A 120 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 120 3x53 G.H5 I 378 G.H5.23
Hydrophobic H8 A 298 8x49 G.H5 Q 381 G.H5.26
Hydrophobic C-term L 385 - H.HD E 172 H.HD.12
Van-der-waals C-term L 385 - H.HD E 172 H.HD.12
Polar C-term A 382 - H.HA D 110 H.HA.24
Hydrophobic C-term A 382 - H.HA D 110 H.HA.24
Van-der-waals C-term A 382 - H.HA D 110 H.HA.24
Hydrophobic H8 R 296 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 R 296 8x47 G.H5 L 380 G.H5.25
Polar TM5 Q 216 5x69 G.H5 D 368 G.H5.13
Hydrophobic TM5 Q 216 5x69 G.H5 D 368 G.H5.13
Van-der-waals TM5 Q 216 5x69 G.H5 D 368 G.H5.13
Polar ICL2 Q 129 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 Q 129 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 Q 129 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 Y 125 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 Y 125 34x51 G.H5 I 370 G.H5.15
Hydrophobic C-term C 383 - H.HA V 107 H.HA.21
Van-der-waals C-term C 383 - H.HA V 107 H.HA.21
Hydrophobic ICL3 L 224 - G.H4 V 332 G.H4.12
Hydrophobic TM6 H 237 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM5 H 220 5x73 G.S6 F 347 G.S6.02
Ionic ICL2 D 131 34x57 G.hns1 R 55 G.hns1.02
Polar ICL2 D 131 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 D 131 34x57 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 D 131 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic C-term A 382 - H.HA V 107 H.HA.21
Van-der-waals C-term A 382 - H.HA V 107 H.HA.21
Hydrophobic ICL2 Y 125 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 Y 125 34x51 G.S3 I 221 G.S3.01
Hydrophobic C-term L 385 - H.HA L 115 H.HA.29
Van-der-waals C-term L 385 - H.HA L 115 H.HA.29
Hydrophobic ICL3 L 224 - G.H4 Q 333 G.H4.13
Hydrophobic C-term W 352 - G.H2 Q 236 G.H2.05
Van-der-waals C-term W 352 - G.H2 Q 236 G.H2.05
Hydrophobic C-term C 383 - H.hdhe F 173 H.hdhe.01
Van-der-waals C-term C 383 - H.hdhe F 173 H.hdhe.01
Hydrophobic TM3 L 121 3x54 G.H5 L 375 G.H5.20
Polar C-term C 383 - H.HA K 114 H.HA.28
Hydrophobic C-term C 383 - H.HA K 114 H.HA.28
Van-der-waals C-term C 383 - H.HA K 114 H.HA.28
Polar C-term C 383 - H.HA D 110 H.HA.24
Hydrophobic C-term C 383 - H.HA D 110 H.HA.24
Van-der-waals C-term C 383 - H.HA D 110 H.HA.24
Hydrophobic TM4 R 134 4x40 G.HN A 48 G.HN.48
Hydrophobic ICL2 Y 125 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 Y 125 34x51 G.S1 V 58 G.S1.02
Polar ICL2 Y 125 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 Y 125 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 Y 125 34x51 G.H5 K 367 G.H5.12
Hydrophobic C-term S 384 - H.hdhe F 173 H.hdhe.01
Van-der-waals C-term S 384 - H.hdhe F 173 H.hdhe.01
Hydrophobic TM6 D 233 6x29 G.H5 L 375 G.H5.20
Polar C-term S 384 - H.hdhe Q 174 H.hdhe.02
Polar TM1 R 41 1x60 G.H5 L 380 G.H5.25
Van-der-waals TM1 R 41 1x60 G.H5 L 380 G.H5.25
Hydrophobic ICL3 L 224 - G.S6 H 348 G.S6.03
Hydrophobic ICL2 A 128 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 A 128 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 Y 125 34x51 G.S3 F 223 G.S3.03
Hydrophobic TM5 M 213 5x66 G.H5 Q 372 G.H5.17
Hydrophobic C-term C 386 - G.s4h3 V 260 G.s4h3.07
Van-der-waals C-term C 386 - G.s4h3 V 260 G.s4h3.07
Hydrophobic C-term A 382 - H.HA R 106 H.HA.20
Polar C-term C 383 - H.HA A 111 H.HA.25
Hydrophobic C-term C 383 - H.HA A 111 H.HA.25
Van-der-waals C-term C 383 - H.HA A 111 H.HA.25
Hydrophobic ICL2 P 124 34x50 G.H5 L 371 G.H5.16
Van-der-waals ICL2 P 124 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM3 L 121 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 121 3x54 G.H5 L 371 G.H5.16
Polar ICL2 Y 125 34x51 G.H5 F 363 G.H5.08
Aromatic ICL2 Y 125 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 Y 125 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 Y 125 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 Q 129 34x55 G.S3 P 222 G.S3.02
Hydrophobic TM5 L 210 5x63 G.H5 L 375 G.H5.20
Hydrophobic TM6 H 237 6x33 G.H5 I 378 G.H5.23
Van-der-waals TM6 H 237 6x33 G.H5 I 378 G.H5.23
Hydrophobic ICL3 T 230 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 T 230 - G.h4s6 S 343 G.h4s6.12
Hydrophobic TM5 M 213 5x66 G.H5 L 371 G.H5.16
Van-der-waals TM5 M 213 5x66 G.H5 L 371 G.H5.16
Polar C-term C 386 - H.hdhe Q 174 H.hdhe.02
Hydrophobic C-term C 386 - H.hdhe Q 174 H.hdhe.02
Van-der-waals C-term C 386 - H.hdhe Q 174 H.hdhe.02
Hydrophobic TM2 A 50 2x40 G.H5 L 380 G.H5.25
Polar C-term C 386 - H.HD E 172 H.HD.12
Hydrophobic C-term C 386 - H.HD E 172 H.HD.12
Van-der-waals C-term C 386 - H.HD E 172 H.HD.12
Polar ICL3 R 227 - G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL3 R 227 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 R 227 - G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL2 Y 125 34x51 G.H5 V 366 G.H5.11
Polar H8 R 296 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 R 296 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 R 296 8x47 G.H5 M 379 G.H5.24
Polar TM6 D 233 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 D 233 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM1 L 38 1x57 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 124 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 124 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 Y 127 34x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 124 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 124 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM6 H 237 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 H 237 6x33 G.H5 L 375 G.H5.20
Polar C-term S 380 - H.HA R 106 H.HA.20
Van-der-waals C-term S 380 - H.HA R 106 H.HA.20
Hydrophobic C-term L 385 - H.HA K 114 H.HA.28
Hydrophobic TM3 L 121 3x54 G.H5 I 378 G.H5.23
Hydrophobic C-term C 386 - G.s4h3 R 265 G.s4h3.12
Hydrophobic TM6 E 234 6x30 G.H5 L 375 G.H5.20
Hydrophobic TM3 R 117 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 117 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM6 D 233 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 D 233 6x29 G.H5 M 379 G.H5.24
Hydrophobic TM2 F 49 2x39 G.H5 I 378 G.H5.23
Polar H8 R 296 8x47 G.H5 I 378 G.H5.23
Hydrophobic H8 R 296 8x47 G.H5 I 378 G.H5.23
Van-der-waals H8 R 296 8x47 G.H5 I 378 G.H5.23
Aromatic C-term W 352 - G.H2 F 239 G.H2.08
Hydrophobic C-term W 352 - G.H2 F 239 G.H2.08
Van-der-waals C-term W 352 - G.H2 F 239 G.H2.08
Polar ICL3 S 223 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 S 223 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 S 223 - G.S6 H 348 G.S6.03
Hydrophobic C-term W 352 - G.H2 R 235 G.H2.04