G11 - PKR1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 166 3x54 G.H5 L 353 G.H5.20
Hydrophobic TM5 P 265 5x71 G.H5 A 343 G.H5.10
Van-der-waals TM5 P 265 5x71 G.H5 A 343 G.H5.10
Hydrophobic ICL2 L 170 - G.H5 K 345 G.H5.12
Hydrophobic TM5 P 265 5x71 G.H5 D 346 G.H5.13
Polar ICL4 K 346 - G.H5 L 358 G.H5.25
Hydrophobic ICL4 K 346 - G.H5 L 358 G.H5.25
Van-der-waals ICL4 K 346 - G.H5 L 358 G.H5.25
Ionic TM6 R 279 6x30 G.H5 D 346 G.H5.13
Polar TM6 R 279 6x30 G.H5 D 346 G.H5.13
Hydrophobic TM6 R 279 6x30 G.H5 D 346 G.H5.13
Van-der-waals TM6 R 279 6x30 G.H5 D 346 G.H5.13
Hydrophobic ICL2 L 170 - G.H5 I 348 G.H5.15
Van-der-waals ICL2 L 170 - G.H5 I 348 G.H5.15
Hydrophobic TM5 V 264 5x70 G.H5 D 346 G.H5.13
Hydrophobic TM5 V 264 5x70 G.S6 Y 325 G.S6.02
Hydrophobic TM6 Q 271 6x22 G.h4s6 I 323 G.h4s6.20
Hydrophobic TM6 R 275 6x26 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM6 R 275 6x26 G.h4s6 I 323 G.h4s6.20
Hydrophobic TM5 L 259 5x65 G.H5 L 349 G.H5.16
Polar ICL2 R 173 - G.hns1 R 37 G.hns1.02
Hydrophobic TM5 P 265 5x71 G.H5 A 342 G.H5.09
Polar TM6 T 282 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 T 282 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 T 282 6x33 G.H5 L 358 G.H5.25
Hydrophobic ICL2 P 169 - G.H5 L 349 G.H5.16
Hydrophobic ICL3 T 269 - G.H4 L 310 G.H4.12
Hydrophobic TM3 R 162 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM3 A 165 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 165 3x53 G.H5 Y 356 G.H5.23
Polar TM3 R 162 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 162 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 162 3x50 G.H5 Y 356 G.H5.23
Ionic TM6 R 275 6x26 G.H5 D 346 G.H5.13
Polar TM6 R 275 6x26 G.H5 D 346 G.H5.13
Van-der-waals TM6 R 275 6x26 G.H5 D 346 G.H5.13
Hydrophobic ICL4 K 346 - G.H5 V 359 G.H5.26
Van-der-waals ICL4 K 346 - G.H5 V 359 G.H5.26
Polar TM5 F 267 5x73 G.S6 S 326 G.S6.03
Hydrophobic TM5 F 267 5x73 G.S6 S 326 G.S6.03
Van-der-waals TM5 F 267 5x73 G.S6 S 326 G.S6.03
Polar TM6 R 275 6x26 G.H5 Q 350 G.H5.17
Hydrophobic TM6 R 275 6x26 G.H5 Q 350 G.H5.17
Van-der-waals TM6 R 275 6x26 G.H5 Q 350 G.H5.17
Polar ICL2 P 169 - G.H5 N 352 G.H5.19
Polar TM2 T 97 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM2 T 97 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 T 97 2x39 G.H5 Y 356 G.H5.23
Polar TM3 A 165 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 165 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 165 3x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 L 170 - G.S3 I 199 G.S3.01
Van-der-waals ICL2 L 170 - G.S3 I 199 G.S3.01
Hydrophobic TM5 L 259 5x65 G.H5 L 353 G.H5.20
Hydrophobic ICL3 T 269 - G.H4 V 314 G.H4.16
Ionic ICL2 R 173 - G.H5 E 355 G.H5.22
Polar ICL2 R 173 - G.H5 E 355 G.H5.22
Hydrophobic ICL2 R 173 - G.H5 E 355 G.H5.22
Van-der-waals ICL2 R 173 - G.H5 E 355 G.H5.22
Polar ICL2 R 173 - G.H5 N 352 G.H5.19
Hydrophobic ICL2 R 173 - G.H5 N 352 G.H5.19
Van-der-waals ICL2 R 173 - G.H5 N 352 G.H5.19
Polar TM6 Q 271 6x22 G.h4s6 S 320 G.h4s6.11
Van-der-waals TM6 Q 271 6x22 G.h4s6 S 320 G.h4s6.11
Hydrophobic TM5 G 266 5x72 G.S6 S 326 G.S6.03
Van-der-waals TM5 G 266 5x72 G.S6 S 326 G.S6.03
Hydrophobic TM5 G 266 5x72 G.H5 F 339 G.H5.06
Van-der-waals TM5 G 266 5x72 G.H5 F 339 G.H5.06
Polar TM6 R 275 6x26 G.S6 Y 325 G.S6.02
Van-der-waals TM6 R 275 6x26 G.S6 Y 325 G.S6.02
Polar TM6 Q 271 6x22 G.h4s6 K 322 G.h4s6.13
Hydrophobic TM6 Q 271 6x22 G.h4s6 K 322 G.h4s6.13
Van-der-waals TM6 Q 271 6x22 G.h4s6 K 322 G.h4s6.13
Hydrophobic TM5 P 265 5x71 G.S6 Y 325 G.S6.02
Van-der-waals TM5 P 265 5x71 G.S6 Y 325 G.S6.02
Polar TM6 Q 271 6x22 G.S6 I 324 G.S6.01
Van-der-waals TM6 Q 271 6x22 G.S6 I 324 G.S6.01
Hydrophobic TM6 R 279 6x30 G.H5 L 353 G.H5.20
Hydrophobic TM6 T 282 6x33 G.H5 L 353 G.H5.20
Hydrophobic TM6 I 272 6x23 G.S6 Y 325 G.S6.02
Polar H8 N 347 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 N 347 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 N 347 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM5 F 267 5x73 G.H4 L 310 G.H4.12
Van-der-waals TM5 F 267 5x73 G.H4 L 310 G.H4.12
Polar TM2 N 95 2x37 G.H5 E 355 G.H5.22
Hydrophobic TM2 N 95 2x37 G.H5 E 355 G.H5.22
Van-der-waals TM2 N 95 2x37 G.H5 E 355 G.H5.22
Hydrophobic TM5 F 267 5x73 G.S6 F 328 G.S6.05
Van-der-waals TM5 F 267 5x73 G.S6 F 328 G.S6.05
Polar ICL2 R 173 - G.H5 Y 356 G.H5.23
Hydrophobic ICL2 R 173 - G.H5 Y 356 G.H5.23
Van-der-waals ICL2 R 173 - G.H5 Y 356 G.H5.23
Hydrophobic TM5 F 267 5x73 G.H4 E 307 G.H4.09
Hydrophobic TM6 I 272 6x23 G.h4s6 I 323 G.h4s6.20
Hydrophobic TM6 R 279 6x30 G.H5 L 349 G.H5.16
Hydrophobic TM3 I 166 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 I 166 3x54 G.H5 L 349 G.H5.16
Hydrophobic ICL2 P 169 - G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 169 - G.H5 I 348 G.H5.15
Polar TM2 T 97 2x39 G.H5 E 355 G.H5.22
Hydrophobic ICL2 L 170 - G.H5 F 341 G.H5.08
Van-der-waals ICL2 L 170 - G.H5 F 341 G.H5.08
Hydrophobic ICL2 P 169 - G.H5 K 345 G.H5.12
Hydrophobic ICL4 K 346 - G.H5 N 357 G.H5.24
Van-der-waals ICL4 K 346 - G.H5 N 357 G.H5.24
Hydrophobic TM6 L 286 6x37 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 286 6x37 G.H5 L 358 G.H5.25
Ionic TM5 E 258 5x64 G.H5 K 345 G.H5.12
Hydrophobic ICL2 L 170 - G.S1 L 40 G.S1.02
Hydrophobic TM5 P 265 5x71 G.H5 F 339 G.H5.06
Hydrophobic TM3 I 166 3x54 G.H5 L 358 G.H5.25
Polar TM3 D 161 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 161 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 161 3x49 G.H5 Y 356 G.H5.23